Investigating the genomic alteration improved the clinical outcome of aged patients with lung carcinoma

Investigating the genomic alteration improved the clinical outcome of aged patients with lung carcinoma

Abstract Background Lung carcinoma is a common geriatric disease. The development of genotype-targeted therapies greatly improved the management of lung carcinoma. However, the treatment for old patients can be more complex than that for young individuals. Results To investigate the benefits of gene...

Full description

Bibliographic Details
Main Authors:	Sixian Chen, Aizhen Fu, Yuan Lu, Wei Lu, Yongfeng Chen, Shuiqiang Hong, Suli Zhou, Tianmin Xiang, Zhenzhen Zhang, Yongguang Cai
Format:	Article
Language:	English
Published:	BMC 2022-01-01
Series:	BMC Genomics
Subjects:	Lung cancer Genomic alterations KRAS codon 61 Targeted treatment Mechanism of resistance
Online Access:	https://doi.org/10.1186/s12864-021-08289-4

Similar Items

Higher prevalence of KRAS mutations in colorectal cancer in Saudi Arabia: Propensity for lung metastasis
by: Talha Bader, et al.
Published: (2014-09-01)

Targeted Therapy in Advanced and Metastatic Non-Small Cell Lung Cancer. An Update on Treatment of the Most Important Actionable Oncogenic Driver Alterations
by: David König, et al.
Published: (2021-02-01)

A Potential Biomarker of Combination of Tumor Mutation Burden and Copy Number Alteration for Efficacy of Immunotherapy in KRAS-Mutant Advanced Lung Adenocarcinoma
by: Luochengling Xiang, et al.
Published: (2020-09-01)

Low-Coverage Whole Genome Sequencing Using Laser Capture Microscopy with Combined Digital Droplet PCR: An Effective Tool to Study Copy Number and Kras Mutations in Early Lung Adenocarcinoma Development
by: Elizabeth A. Mickler, et al.
Published: (2021-11-01)

KRAS Codon 12 and 13 Mutations in Gastric Cancer in the Northeast Iran
by: Hossein Ayatollahi, et al.
Published: (2018-04-01)

EGFR, KRAS, BRAF, ALK, and cMET genetic alterations in 1440 Sardinian patients with lung adenocarcinoma
by: Maria Colombino, et al.
Published: (2019-11-01)

The KRASG12C inhibitors in lung cancer therapy
by: Maciej Jędrak, et al.
Published: (2023-09-01)

Research Progress of KRAS Mutation in Non-small Cell Lung Cancer
by: Lei LIU, et al.
Published: (2018-05-01)

Morphological and Molecular Characterization of KRAS G12C-Mutated Lung Adenocarcinomas
by: Radu Pirlog, et al.
Published: (2022-02-01)

Assessing optimal: inequalities in codon optimization algorithms
by: Matthew J. Ranaghan, et al.
Published: (2021-02-01)

KRAS Mutation: Characterization and Its Impact on Survival Outcome of Patients with Metastatic Colorectal Cancer
by: Datul Damit, et al.
Published: (2022-07-01)

Clinical and Imaging Features of Non-Small Cell Lung Cancer with G12C KRAS Mutation
by: Markus Y. Wu, et al.
Published: (2021-07-01)

Effect of <it>KRAS</it> codon13 mutations in patients with advanced colorectal cancer (advanced CRC) under oxaliplatin containing chemotherapy. Results from a translational study of the AIO colorectal study group
by: Reinacher-Schick Anke, et al.
Published: (2012-08-01)

Genomic landscape of clinically advanced KRAS wild-type pancreatic ductal adenocarcinoma
by: Prashanth Ashok Kumar, et al.
Published: (2023-06-01)

The Role of Genetic, Metabolic, Inflammatory, and Immunologic Mediators in the Progression of Intraductal Papillary Mucinous Neoplasms to Pancreatic Adenocarcinoma
by: Kylie E. Shockley, et al.
Published: (2023-03-01)

Association between Contrast-Enhanced Computed Tomography Radiomic Features, Genomic Alterations and Prognosis in Advanced Lung Adenocarcinoma Patients
by: Lisa Rinaldi, et al.
Published: (2023-09-01)

The Renaissance of KRAS Targeting in Advanced Non-Small-Cell Lung Cancer: New Opportunities Following Old Failures
by: Miriam Grazia Ferrara, et al.
Published: (2021-12-01)

Novel Therapeutic Approaches for KRAS-Mutated Lung Cancer Involving LZTR1 Genetic Alteration
by: Raj N. Sewduth, et al.
Published: (2023-03-01)

Targeting KRAS in Non-Small Cell Lung Cancer
by: Elena Corral de la Fuente, et al.
Published: (2022-01-01)

KRAS Gene Mutations and Gender Differences in Colorectal Cancer
by: Dmitriy I. Vodolazhskiy, et al.
Published: (2015-03-01)

Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer
by: April Lo, et al.
Published: (2022-12-01)

Targeting <i>KRAS</i> Mutant Non-Small-Cell Lung Cancer: Past, Present and Future
by: Iris Z. Uras, et al.
Published: (2020-06-01)

Epigenetic Input Dictates the Threshold of Targeting of the Integrin-Dependent Pathway in Non-small Cell Lung Cancer
by: Yang Zhang, et al.
Published: (2020-07-01)

Peritoneum as the sole distant metastatic site of lung adenosquamous cell carcinoma: a case report
by: Pan Yang, et al.
Published: (2017-09-01)

Analysis of Genetic Alterations in Tunisian Patients with Lung Adenocarcinoma
by: Dhoha Dhieb, et al.
Published: (2019-05-01)

<i>KRAS</i> Mutational Profiles among Colorectal Cancer Patients in the East Coast of Peninsular Malaysia
by: Hidayati Husainy Hasbullah, et al.
Published: (2023-02-01)

Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology
by: Elio Adib, et al.
Published: (2022-04-01)

Antitumor efficacy of XPO1 inhibitor Selinexor in KRAS-mutant lung adenocarcinoma patient-derived xenografts
by: Joshua C. Rosen, et al.
Published: (2021-10-01)

CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development
by: Etienne S. Melese, et al.
Published: (2022-01-01)

Alterations in epidermal growth factor receptors 1 and 2 in esophageal squamous cell carcinomas
by: Gonzaga Isabela Martins, et al.
Published: (2012-12-01)

RANKL acts an unfavorable prognostic biomarker and potential target in advanced KRAS‐mutated lung adenocarcinoma
by: Hong‐Shuai Li, et al.
Published: (2023-05-01)

The Metabolic Landscape of Lung Cancer: New Insights in a Disturbed Glucose Metabolism
by: Karolien Vanhove, et al.
Published: (2019-11-01)

Novel Emerging Molecular Targets in Non-Small Cell Lung Cancer
by: Sara Elena Rebuzzi, et al.
Published: (2021-03-01)

New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness
by: Haitang Yang, et al.
Published: (2019-09-01)

Research Progress of Proteolysis Targeting Chimeria in NSCLC Therapy
by: Lin JIANG, et al.
Published: (2022-07-01)

Efficacy Differences of First-line EGFR-TKIs Alone vs in Combination with Chemotherapy in Advanced Lung Adenocarcinoma Patients with Sensitive EGFR Mutation and Concomitant Non-EGFR Genetic Alterations
by: Guowei ZHANG, et al.
Published: (2022-09-01)

Light at the end of the tunnel: Clinical features and therapeutic prospects of KRAS mutant subtypes in non-small-cell lung cancer
by: Liyuan Gao, et al.
Published: (2022-10-01)

Different gene alterations in patients with non-small-cell lung cancer between the eastern and southern China
by: Chengdong Liu, et al.
Published: (2023-10-01)

Epidermal growth factor receptor and KRAS mutations in Brazilian lung cancer patients
by: Carlos E. Bacchi, et al.
Published: (2012-01-01)

Characterization With KRAS Mutant Is a Critical Determinant in Immunotherapy and Other Multiple Therapies for Non-Small Cell Lung Cancer
by: Mo Shen, et al.
Published: (2022-01-01)