Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury

Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury

We assessed the effect of antioxidant therapy using the Food and Drug Administration-approved respiratory drug <i>N</i>-acetylcysteine (NAC) or sulforaphane (SFN) as monotherapies or duotherapy in vitro in neuron-BV2 microglial co-cultures and validated the results in a lateral fluid-per...

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Bibliographic Details
Main Authors: Jenni Kyyriäinen, Natallie Kajevu, Ivette Bañuelos, Leonardo Lara, Anssi Lipponen, Silvia Balosso, Elina Hämäläinen, Shalini Das Gupta, Noora Puhakka, Teemu Natunen, Teresa Ravizza, Annamaria Vezzani, Mikko Hiltunen, Asla Pitkänen
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
antioxidant treatment
cytokine
lateral fluid-percussion injury
<i>N</i>-acetylcysteine
oxidative stress
sulforaphane
Online Access:https://www.mdpi.com/1422-0067/22/19/10555

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