MicroRNA-203a inhibits breast cancer progression through the PI3K/Akt and Wnt pathways
Abstract MicroRNA expression in breast cancer (BC) is explored both as a potential biomarker and for therapeutic purposes. Recent studies have revealed that miR-203a-3p is involved in BC, and importantly contributes to BC chemotherapy responses; however, the regulatory pathways of miR-203a in BC rem...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52940-5 |
| _version_ | 1797275167227904000 |
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| author | Maryam Entezari Bahram M. Soltani Majid Sadeghizadeh |
| author_facet | Maryam Entezari Bahram M. Soltani Majid Sadeghizadeh |
| author_sort | Maryam Entezari |
| collection | DOAJ |
| description | Abstract MicroRNA expression in breast cancer (BC) is explored both as a potential biomarker and for therapeutic purposes. Recent studies have revealed that miR-203a-3p is involved in BC, and importantly contributes to BC chemotherapy responses; however, the regulatory pathways of miR-203a in BC remain elusive. Hence, we aimed to investigate the miR-203a regulatory mechanisms and their potential functions in the progress of BC. To this end, the miR-203a potential involving pathways was predicted by databases analyzing its target genes. The relations between miR-203a, the phosphatidylinositol 3′-kinase (PI3K)–Akt, and Wnt signaling pathways were mechanistically investigated. Our results revealed that miR-203a inhibited the activation of the PI3K/Akt and Wnt pathways and reduced its downstream cell cycle signals, including Cyclin D1 and c-Myc. Moreover, the overexpression of miR-203a drastically arrested the cell cycle at subG1 and G1 phases, decreased the viability, proliferation, and migration, and increased apoptosis of BC cells. Therefore, miR-203a-3p may be considered a tumor suppressor factor and a potential biomarker or therapeutic target for BC. |
| first_indexed | 2024-03-07T15:09:25Z |
| format | Article |
| id | doaj.art-b998415fb61742caa2e625d88c9a739b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:09:25Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b998415fb61742caa2e625d88c9a739b2024-03-05T18:45:09ZengNature PortfolioScientific Reports2045-23222024-02-0114111010.1038/s41598-024-52940-5MicroRNA-203a inhibits breast cancer progression through the PI3K/Akt and Wnt pathwaysMaryam Entezari0Bahram M. Soltani1Majid Sadeghizadeh2Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares UniversityDepartment of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares UniversityDepartment of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares UniversityAbstract MicroRNA expression in breast cancer (BC) is explored both as a potential biomarker and for therapeutic purposes. Recent studies have revealed that miR-203a-3p is involved in BC, and importantly contributes to BC chemotherapy responses; however, the regulatory pathways of miR-203a in BC remain elusive. Hence, we aimed to investigate the miR-203a regulatory mechanisms and their potential functions in the progress of BC. To this end, the miR-203a potential involving pathways was predicted by databases analyzing its target genes. The relations between miR-203a, the phosphatidylinositol 3′-kinase (PI3K)–Akt, and Wnt signaling pathways were mechanistically investigated. Our results revealed that miR-203a inhibited the activation of the PI3K/Akt and Wnt pathways and reduced its downstream cell cycle signals, including Cyclin D1 and c-Myc. Moreover, the overexpression of miR-203a drastically arrested the cell cycle at subG1 and G1 phases, decreased the viability, proliferation, and migration, and increased apoptosis of BC cells. Therefore, miR-203a-3p may be considered a tumor suppressor factor and a potential biomarker or therapeutic target for BC.https://doi.org/10.1038/s41598-024-52940-5 |
| spellingShingle | Maryam Entezari Bahram M. Soltani Majid Sadeghizadeh MicroRNA-203a inhibits breast cancer progression through the PI3K/Akt and Wnt pathways Scientific Reports |
| title | MicroRNA-203a inhibits breast cancer progression through the PI3K/Akt and Wnt pathways |
| title_full | MicroRNA-203a inhibits breast cancer progression through the PI3K/Akt and Wnt pathways |
| title_fullStr | MicroRNA-203a inhibits breast cancer progression through the PI3K/Akt and Wnt pathways |
| title_full_unstemmed | MicroRNA-203a inhibits breast cancer progression through the PI3K/Akt and Wnt pathways |
| title_short | MicroRNA-203a inhibits breast cancer progression through the PI3K/Akt and Wnt pathways |
| title_sort | microrna 203a inhibits breast cancer progression through the pi3k akt and wnt pathways |
| url | https://doi.org/10.1038/s41598-024-52940-5 |
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