ATG Ubiquitination Is Required for Circumsporozoite Protein to Subvert Host Innate Immunity Against Rodent Malaria Liver Stage

ATG Ubiquitination Is Required for Circumsporozoite Protein to Subvert Host Innate Immunity Against Rodent Malaria Liver Stage

Although exo-erythrocytic forms (EEFs) of liver stage malaria parasite in the parasitophorous vacuole (PV) are encountered with robust host innate immunity, EEFs can still survive and successfully complete the infection of hepatocytes, and the underlying mechanism is largely unknown. Here, we showed...

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Bibliographic Details
Main Authors: Hong Zheng, Xiao Lu, Kai Li, Feng Zhu, Chenhao Zhao, Taiping Liu, Yan Ding, Yong Fu, Kun Zhang, Taoli Zhou, Jigang Dai, Yuzhang Wu, Wenyue Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
Plasmodium
malaria
sporozoites
exo-erythrocytic forms
circumsporozoite protein
IFN-γ
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.815936/full

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