Vitamin D receptor gene polymorphisms and risk of hepatocellular carcinoma in hepatitis C-related liver cirrhosis
Abstract Background HCV is a major risk factor for HCC; however, the exact mechanism of hepatocarcinogenesis is still not fully understood. Host genetic factors have been reported to play a significant role. Experimental studies support the tumor inhibitory effect of vitamin D on HCC cells. Several...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-01-01
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| Series: | Egyptian Liver Journal |
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| Online Access: | https://doi.org/10.1186/s43066-020-00067-3 |
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| author | Ghada M. Galal Ahmad Abudeif Nagwa Sayed Ahmed Nahed Fathallah Fahmy Abeer Sheneef Elsayed Mostafa Ali Usama M. Abdelaal Asmaa Naser Mohammad |
| author_facet | Ghada M. Galal Ahmad Abudeif Nagwa Sayed Ahmed Nahed Fathallah Fahmy Abeer Sheneef Elsayed Mostafa Ali Usama M. Abdelaal Asmaa Naser Mohammad |
| author_sort | Ghada M. Galal |
| collection | DOAJ |
| description | Abstract Background HCV is a major risk factor for HCC; however, the exact mechanism of hepatocarcinogenesis is still not fully understood. Host genetic factors have been reported to play a significant role. Experimental studies support the tumor inhibitory effect of vitamin D on HCC cells. Several single nucleotide polymorphisms (SNPs) have been depicted in the vitamin D receptor (VDR) gene. We aimed to assess whether any of these polymorphisms could be significantly associated with increased risk of HCC. Results This study was conducted on 76 patients with HCV-related liver cirrhosis (48 patients had HCC on top of cirrhosis, and the other 28 had liver cirrhosis only). All patients underwent full medical history assessment, clinical examination, laboratory investigations, abdominal ultrasonography, and genotyping of the VDR gene. HCC patients had a significantly higher frequency of ApaI CC genotype compared with those patients without HCC. There is no statistically significant difference between the studied groups at any TaqI genotypes, but the carriage of the ApaI CC genotype had a significant association with liver disease severity in both patients groups compared with ApaI CA/AA genotypes. The carriage of the ApaI CC genotype was an independent predictor for HCC in HCV-related liver cirrhosis. Conclusions VDR ApaI polymorphism is significantly associated with the development of HCC; thus, ApaI CC genotype could be used as an important molecular marker to predict the risk of HCC in patients with HCV-related liver cirrhosis. |
| first_indexed | 2024-12-14T15:18:13Z |
| format | Article |
| id | doaj.art-b99b290bac734cf0a71ce57f4bf5f60c |
| institution | Directory Open Access Journal |
| issn | 2090-6226 |
| language | English |
| last_indexed | 2024-12-14T15:18:13Z |
| publishDate | 2021-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Liver Journal |
| spelling | doaj.art-b99b290bac734cf0a71ce57f4bf5f60c2022-12-21T22:56:15ZengSpringerOpenEgyptian Liver Journal2090-62262021-01-011111910.1186/s43066-020-00067-3Vitamin D receptor gene polymorphisms and risk of hepatocellular carcinoma in hepatitis C-related liver cirrhosisGhada M. Galal0Ahmad Abudeif1Nagwa Sayed Ahmed2Nahed Fathallah Fahmy3Abeer Sheneef4Elsayed Mostafa Ali5Usama M. Abdelaal6Asmaa Naser Mohammad7Department of Tropical Medicine and Gastroenterology, Sohag University HospitalDepartment of Tropical Medicine and Gastroenterology, Sohag University HospitalMedical Biochemistry, Sohag Faculty of Medicine, Sohag University HospitalMicrobiology and Immunology, Sohag Faculty of Medicine, Sohag University HospitalMicrobiology and Immunology, Sohag Faculty of Medicine, Sohag University HospitalClinical Oncology Department, Sohag Faculty of Medicine, Sohag University HospitalDepartment of Internal Medicine, Sohag UniversityDepartment of Tropical Medicine and Gastroenterology, Sohag University HospitalAbstract Background HCV is a major risk factor for HCC; however, the exact mechanism of hepatocarcinogenesis is still not fully understood. Host genetic factors have been reported to play a significant role. Experimental studies support the tumor inhibitory effect of vitamin D on HCC cells. Several single nucleotide polymorphisms (SNPs) have been depicted in the vitamin D receptor (VDR) gene. We aimed to assess whether any of these polymorphisms could be significantly associated with increased risk of HCC. Results This study was conducted on 76 patients with HCV-related liver cirrhosis (48 patients had HCC on top of cirrhosis, and the other 28 had liver cirrhosis only). All patients underwent full medical history assessment, clinical examination, laboratory investigations, abdominal ultrasonography, and genotyping of the VDR gene. HCC patients had a significantly higher frequency of ApaI CC genotype compared with those patients without HCC. There is no statistically significant difference between the studied groups at any TaqI genotypes, but the carriage of the ApaI CC genotype had a significant association with liver disease severity in both patients groups compared with ApaI CA/AA genotypes. The carriage of the ApaI CC genotype was an independent predictor for HCC in HCV-related liver cirrhosis. Conclusions VDR ApaI polymorphism is significantly associated with the development of HCC; thus, ApaI CC genotype could be used as an important molecular marker to predict the risk of HCC in patients with HCV-related liver cirrhosis.https://doi.org/10.1186/s43066-020-00067-3Vitamin D receptorGene polymorphismHepatocellular carcinomaHepatitis C virusLiver cirrhosis |
| spellingShingle | Ghada M. Galal Ahmad Abudeif Nagwa Sayed Ahmed Nahed Fathallah Fahmy Abeer Sheneef Elsayed Mostafa Ali Usama M. Abdelaal Asmaa Naser Mohammad Vitamin D receptor gene polymorphisms and risk of hepatocellular carcinoma in hepatitis C-related liver cirrhosis Egyptian Liver Journal Vitamin D receptor Gene polymorphism Hepatocellular carcinoma Hepatitis C virus Liver cirrhosis |
| title | Vitamin D receptor gene polymorphisms and risk of hepatocellular carcinoma in hepatitis C-related liver cirrhosis |
| title_full | Vitamin D receptor gene polymorphisms and risk of hepatocellular carcinoma in hepatitis C-related liver cirrhosis |
| title_fullStr | Vitamin D receptor gene polymorphisms and risk of hepatocellular carcinoma in hepatitis C-related liver cirrhosis |
| title_full_unstemmed | Vitamin D receptor gene polymorphisms and risk of hepatocellular carcinoma in hepatitis C-related liver cirrhosis |
| title_short | Vitamin D receptor gene polymorphisms and risk of hepatocellular carcinoma in hepatitis C-related liver cirrhosis |
| title_sort | vitamin d receptor gene polymorphisms and risk of hepatocellular carcinoma in hepatitis c related liver cirrhosis |
| topic | Vitamin D receptor Gene polymorphism Hepatocellular carcinoma Hepatitis C virus Liver cirrhosis |
| url | https://doi.org/10.1186/s43066-020-00067-3 |
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