Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis
The current pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While this respiratory virus only causes mild symptoms in younger healthy individuals, elderly people and those with cardiovascular diseases such as systemic hyperte...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/4/1659 |
| _version_ | 1797413475208658944 |
|---|---|
| author | Sarah Seeherman Yuichiro J. Suzuki |
| author_facet | Sarah Seeherman Yuichiro J. Suzuki |
| author_sort | Sarah Seeherman |
| collection | DOAJ |
| description | The current pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While this respiratory virus only causes mild symptoms in younger healthy individuals, elderly people and those with cardiovascular diseases such as systemic hypertension are susceptible to developing severe conditions that can be fatal. SARS-CoV-2 infection is also associated with an increased incidence of cardiovascular diseases such as myocardial injury, acute coronary syndrome, and thromboembolism. Understanding the mechanisms of the effects of this virus on the cardiovascular system should thus help develop therapeutic strategies to reduce the mortality and morbidity associated with SARS-CoV-2 infection. Since this virus causes severe and fatal conditions in older individuals with cardiovascular comorbidities, effective therapies targeting specific populations will likely contribute to ending this pandemic. In this review article, the effects of various viruses—including other coronaviruses, influenza, dengue, and human immunodeficiency virus—on the cardiovascular system are described to help provide molecular mechanisms of pathologies associated with SARS-CoV-2 infection and COVID-19. The goal is to provide mechanistic information from the biology of other viral infections in relation to cardiovascular pathologies for the purpose of developing improved vaccines and therapeutic agents effective in preventing and/or treating the acute and long-term consequences of SARS-CoV-2 and COVID-19. |
| first_indexed | 2024-03-09T05:19:32Z |
| format | Article |
| id | doaj.art-b99b5fb9622c4bf68fc5f8f2ebdbd155 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:19:32Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b99b5fb9622c4bf68fc5f8f2ebdbd1552023-12-03T12:42:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224165910.3390/ijms22041659Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 PathogenesisSarah Seeherman0Yuichiro J. Suzuki1College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USADepartment of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USAThe current pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While this respiratory virus only causes mild symptoms in younger healthy individuals, elderly people and those with cardiovascular diseases such as systemic hypertension are susceptible to developing severe conditions that can be fatal. SARS-CoV-2 infection is also associated with an increased incidence of cardiovascular diseases such as myocardial injury, acute coronary syndrome, and thromboembolism. Understanding the mechanisms of the effects of this virus on the cardiovascular system should thus help develop therapeutic strategies to reduce the mortality and morbidity associated with SARS-CoV-2 infection. Since this virus causes severe and fatal conditions in older individuals with cardiovascular comorbidities, effective therapies targeting specific populations will likely contribute to ending this pandemic. In this review article, the effects of various viruses—including other coronaviruses, influenza, dengue, and human immunodeficiency virus—on the cardiovascular system are described to help provide molecular mechanisms of pathologies associated with SARS-CoV-2 infection and COVID-19. The goal is to provide mechanistic information from the biology of other viral infections in relation to cardiovascular pathologies for the purpose of developing improved vaccines and therapeutic agents effective in preventing and/or treating the acute and long-term consequences of SARS-CoV-2 and COVID-19.https://www.mdpi.com/1422-0067/22/4/1659ACE2cardiovascularcoronavirusCOVID-19dengueheart |
| spellingShingle | Sarah Seeherman Yuichiro J. Suzuki Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis International Journal of Molecular Sciences ACE2 cardiovascular coronavirus COVID-19 dengue heart |
| title | Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis |
| title_full | Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis |
| title_fullStr | Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis |
| title_full_unstemmed | Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis |
| title_short | Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis |
| title_sort | viral infection and cardiovascular disease implications for the molecular basis of covid 19 pathogenesis |
| topic | ACE2 cardiovascular coronavirus COVID-19 dengue heart |
| url | https://www.mdpi.com/1422-0067/22/4/1659 |
| work_keys_str_mv | AT sarahseeherman viralinfectionandcardiovasculardiseaseimplicationsforthemolecularbasisofcovid19pathogenesis AT yuichirojsuzuki viralinfectionandcardiovasculardiseaseimplicationsforthemolecularbasisofcovid19pathogenesis |