The Multifaceted Role of Serotonin in Intestinal Homeostasis
The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes and a wide range of functions. In the gastrointestinal tract, enterochromaffin cells are the most important source for 5-HT production. Some intestinal bacterial spec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/17/9487 |
| _version_ | 1797521331213828096 |
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| author | Nienke Koopman Drosos Katsavelis Anne S. Ten Hove Stanley Brul Wouter J. de Jonge Jurgen Seppen |
| author_facet | Nienke Koopman Drosos Katsavelis Anne S. Ten Hove Stanley Brul Wouter J. de Jonge Jurgen Seppen |
| author_sort | Nienke Koopman |
| collection | DOAJ |
| description | The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes and a wide range of functions. In the gastrointestinal tract, enterochromaffin cells are the most important source for 5-HT production. Some intestinal bacterial species are also able to produce 5-HT. Besides its role as a neurotransmitter, 5-HT acts on immune cells to regulate their activation. Several lines of evidence indicate that intestinal 5-HT signaling is altered in patients with inflammatory bowel disease. In this review, we discuss the current knowledge on the production, secretion, and signaling of 5-HT in the intestine. We present an inventory of intestinal immune and epithelial cells that respond to 5-HT and describe the effects of these signaling processes on intestinal homeostasis. Further, we detail the mechanisms by which 5-HT could affect inflammatory bowel disease course and describe the effects of interventions that target intestinal 5-HT signaling. |
| first_indexed | 2024-03-10T08:10:03Z |
| format | Article |
| id | doaj.art-b99c0379b1e64dda82b1c57b76863175 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:10:03Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b99c0379b1e64dda82b1c57b768631752023-11-22T10:44:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012217948710.3390/ijms22179487The Multifaceted Role of Serotonin in Intestinal HomeostasisNienke Koopman0Drosos Katsavelis1Anne S. Ten Hove2Stanley Brul3Wouter J. de Jonge4Jurgen Seppen5Swammerdam Institute for Life Sciences (SILS), University of Amsterdam, 1098XH Amsterdam, The NetherlandsSwammerdam Institute for Life Sciences (SILS), University of Amsterdam, 1098XH Amsterdam, The NetherlandsTytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location AMC, 1105BK Amsterdam, The NetherlandsSwammerdam Institute for Life Sciences (SILS), University of Amsterdam, 1098XH Amsterdam, The NetherlandsTytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location AMC, 1105BK Amsterdam, The NetherlandsTytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location AMC, 1105BK Amsterdam, The NetherlandsThe monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes and a wide range of functions. In the gastrointestinal tract, enterochromaffin cells are the most important source for 5-HT production. Some intestinal bacterial species are also able to produce 5-HT. Besides its role as a neurotransmitter, 5-HT acts on immune cells to regulate their activation. Several lines of evidence indicate that intestinal 5-HT signaling is altered in patients with inflammatory bowel disease. In this review, we discuss the current knowledge on the production, secretion, and signaling of 5-HT in the intestine. We present an inventory of intestinal immune and epithelial cells that respond to 5-HT and describe the effects of these signaling processes on intestinal homeostasis. Further, we detail the mechanisms by which 5-HT could affect inflammatory bowel disease course and describe the effects of interventions that target intestinal 5-HT signaling.https://www.mdpi.com/1422-0067/22/17/9487inflammatory bowel diseaseintestinetryptophanmicrobiome |
| spellingShingle | Nienke Koopman Drosos Katsavelis Anne S. Ten Hove Stanley Brul Wouter J. de Jonge Jurgen Seppen The Multifaceted Role of Serotonin in Intestinal Homeostasis International Journal of Molecular Sciences inflammatory bowel disease intestine tryptophan microbiome |
| title | The Multifaceted Role of Serotonin in Intestinal Homeostasis |
| title_full | The Multifaceted Role of Serotonin in Intestinal Homeostasis |
| title_fullStr | The Multifaceted Role of Serotonin in Intestinal Homeostasis |
| title_full_unstemmed | The Multifaceted Role of Serotonin in Intestinal Homeostasis |
| title_short | The Multifaceted Role of Serotonin in Intestinal Homeostasis |
| title_sort | multifaceted role of serotonin in intestinal homeostasis |
| topic | inflammatory bowel disease intestine tryptophan microbiome |
| url | https://www.mdpi.com/1422-0067/22/17/9487 |
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