The effect of low-dose granisetron on shivering in subarachnoid block
Background: Shivering has many negative effects on the postanesthesia patient. Shivering is regulated by serotonin. The serotonin antagonists such as ondansetron and granisetron are widely used to prevent nausea and vomiting. Ondansetron is used in regional and general anesthesia, while granisetron...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Bali Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://www.bjoaonline.com/article.asp?issn=2549-2276;year=2019;volume=3;issue=3;spage=166;epage=169;aulast=Isngadi |
| _version_ | 1819199157161689088 |
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| author | Isngadi Isngadi Wiwi Jaya Dedy Fardian |
| author_facet | Isngadi Isngadi Wiwi Jaya Dedy Fardian |
| author_sort | Isngadi Isngadi |
| collection | DOAJ |
| description | Background: Shivering has many negative effects on the postanesthesia patient. Shivering is regulated by serotonin. The serotonin antagonists such as ondansetron and granisetron are widely used to prevent nausea and vomiting. Ondansetron is used in regional and general anesthesia, while granisetron is widely used in chemotherapy. This study aimed to determine the effect of low-dose granisetron on the incidence of shivering in postspinal anesthesia. Patients and Methods: The study conducted at Dr. Saiful Anwar General Hospital, Malang, Indonesia. Twenty-three patients divided into two groups: Group C (control) received no premedication and Group G (granisetron) received low-dose granisetron 10 μg/kg. The shivering grade and shivering intensity were recorded every 5 min in the first 1-h postanesthesia. The data were analyzed using t-test, regression test, and effective contribution test. Results: The shivering incidence in Group K was 71.9% and Group G was 9.4% (P = 0.018). The control group experienced shivering Grade I, II, III, and IV. Granisetron group only experienced shivering Grade I and II. Conclusion: The administration of low-dose granisetron before the spinal anesthesia significantly reduced the incidence of shivering in adult patients with no side effects. |
| first_indexed | 2024-12-23T03:11:52Z |
| format | Article |
| id | doaj.art-b99c16a0a77a4ae5a4449bfa882bf5c5 |
| institution | Directory Open Access Journal |
| issn | 2549-2276 |
| language | English |
| last_indexed | 2024-12-23T03:11:52Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Bali Journal of Anesthesiology |
| spelling | doaj.art-b99c16a0a77a4ae5a4449bfa882bf5c52022-12-21T18:02:13ZengWolters Kluwer Medknow PublicationsBali Journal of Anesthesiology2549-22762019-01-013316616910.4103/BJOA.BJOA_4_19The effect of low-dose granisetron on shivering in subarachnoid blockIsngadi IsngadiWiwi JayaDedy FardianBackground: Shivering has many negative effects on the postanesthesia patient. Shivering is regulated by serotonin. The serotonin antagonists such as ondansetron and granisetron are widely used to prevent nausea and vomiting. Ondansetron is used in regional and general anesthesia, while granisetron is widely used in chemotherapy. This study aimed to determine the effect of low-dose granisetron on the incidence of shivering in postspinal anesthesia. Patients and Methods: The study conducted at Dr. Saiful Anwar General Hospital, Malang, Indonesia. Twenty-three patients divided into two groups: Group C (control) received no premedication and Group G (granisetron) received low-dose granisetron 10 μg/kg. The shivering grade and shivering intensity were recorded every 5 min in the first 1-h postanesthesia. The data were analyzed using t-test, regression test, and effective contribution test. Results: The shivering incidence in Group K was 71.9% and Group G was 9.4% (P = 0.018). The control group experienced shivering Grade I, II, III, and IV. Granisetron group only experienced shivering Grade I and II. Conclusion: The administration of low-dose granisetron before the spinal anesthesia significantly reduced the incidence of shivering in adult patients with no side effects.http://www.bjoaonline.com/article.asp?issn=2549-2276;year=2019;volume=3;issue=3;spage=166;epage=169;aulast=Isngadigranisetronlow-doseshiveringspinal anesthesia |
| spellingShingle | Isngadi Isngadi Wiwi Jaya Dedy Fardian The effect of low-dose granisetron on shivering in subarachnoid block Bali Journal of Anesthesiology granisetron low-dose shivering spinal anesthesia |
| title | The effect of low-dose granisetron on shivering in subarachnoid block |
| title_full | The effect of low-dose granisetron on shivering in subarachnoid block |
| title_fullStr | The effect of low-dose granisetron on shivering in subarachnoid block |
| title_full_unstemmed | The effect of low-dose granisetron on shivering in subarachnoid block |
| title_short | The effect of low-dose granisetron on shivering in subarachnoid block |
| title_sort | effect of low dose granisetron on shivering in subarachnoid block |
| topic | granisetron low-dose shivering spinal anesthesia |
| url | http://www.bjoaonline.com/article.asp?issn=2549-2276;year=2019;volume=3;issue=3;spage=166;epage=169;aulast=Isngadi |
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