Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis

Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis

Abstract Disseminated intravascular coagulation (DIC) is one of the major organ dysfunctions associated with sepsis. This retrospective secondary analysis comprised data from a prospective multicenter study to investigate the age-related differences in the survival benefit of anticoagulant therapy i...

Full description

Bibliographic Details
Main Authors:	Takeshi Wada, Kazuma Yamakawa, Daijiro Kabata, Toshikazu Abe, Hiroshi Ogura, Atsushi Shiraishi, Daizoh Saitoh, Shigeki Kushimoto, Seitaro Fujishima, Toshihiko Mayumi, Toru Hifumi, Yasukazu Shiino, Taka-aki Nakada, Takehiko Tarui, Yasuhiro Otomo, Kohji Okamoto, Yutaka Umemura, Joji Kotani, Yuichiro Sakamoto, Junichi Sasaki, Shin-ichiro Shiraishi, Kiyotsugu Takuma, Ryosuke Tsuruta, Akiyoshi Hagiwara, Tomohiko Masuno, Naoshi Takeyama, Norio Yamashita, Hiroto Ikeda, Masashi Ueyama, Satoshi Fujimi, Satoshi Gando
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-06-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-022-13346-3

Similar Items

Association of antithrombin with development of trauma-induced disseminated intravascular coagulation and outcomes
by: Takeshi Wada, et al.
Published: (2022-12-01)

Trends in sepsis care in Japan: comparison of two sepsis cohort studies conducted by the Japanese Association for Acute Medicine
by: Seitaro Fujishima, et al.
Published: (2019-10-01)

Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients
by: Takeshi Wada, et al.
Published: (2021-05-01)

Effects of combination therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation
by: Toshiaki Iba, et al.
Published: (2017-11-01)

Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study
by: Toshikazu Abe, et al.
Published: (2018-11-01)

Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts
by: Takehiko Oami, et al.
Published: (2021-01-01)

Hour-1 bundle adherence was associated with reduction of in-hospital mortality among patients with sepsis in Japan
by: Yutaka Umemura, et al.
Published: (2022-01-01)

Pathophysiology of Coagulopathy Induced by Traumatic Brain Injury Is Identical to That of Disseminated Intravascular Coagulation With Hyperfibrinolysis
by: Takeshi Wada, et al.
Published: (2021-11-01)

Significance of body temperature in elderly patients with sepsis
by: Takashi Shimazui, et al.
Published: (2020-06-01)

Risk modifiers of acute respiratory distress syndrome in patients with non-pulmonary sepsis: a retrospective analysis of the FORECAST study
by: Hiroki Iriyama, et al.
Published: (2020-01-01)

Variations in infection sites and mortality rates among patients in intensive care units with severe sepsis and septic shock in Japan
by: Toshikazu Abe, et al.
Published: (2019-05-01)

Epidemiology of sepsis and septic shock in intensive care units between sepsis-2 and sepsis-3 populations: sepsis prognostication in intensive care unit and emergency room (SPICE-ICU)
by: Toshikazu Abe, et al.
Published: (2020-06-01)

Sepsis-related coagulopathy treatment based on the disseminated intravascular coagulation diagnostic criteria: a post-hoc analysis of a prospective multicenter observational study
by: Takeshi Wada, et al.
Published: (2023-03-01)

Quick sequential organ failure assessment versus systemic inflammatory response syndrome criteria for emergency department patients with suspected infection
by: Atsushi Shiraishi, et al.
Published: (2021-03-01)

Characteristics and outcomes of frail patients with suspected infection in intensive care units: a descriptive analysis from a multicenter cohort study
by: Akira Komori, et al.
Published: (2020-11-01)

Implementation of earlier antibiotic administration in patients with severe sepsis and septic shock in Japan: a descriptive analysis of a prospective observational study
by: Toshikazu Abe, et al.
Published: (2019-11-01)

Hyperoxemia during resuscitation of trauma patients and increased intensive care unit length of stay: inverse probability of treatment weighting analysis
by: Ryo Yamamoto, et al.
Published: (2021-04-01)

In-hospital mortality associated with the misdiagnosis or unidentified site of infection at admission
by: Toshikazu Abe, et al.
Published: (2019-06-01)

Early versus delayed vasopressor administration in patients with septic shock
by: Toshikazu Abe, et al.
Published: (2023-01-01)

Acute Portal Vein Thrombosis Treated with Recombinant Human Soluble Thrombomodulin Combined with Antithrombin III
by: Satoshi Nakayama, et al.
Published: (2020-01-01)

Quick sequential organ failure assessment score combined with other sepsis-related risk factors to predict in-hospital mortality: Post-hoc analysis of prospective multicenter study data.
by: Ryo Ueno, et al.
Published: (2021-01-01)

Sepsis-Associated DIC with Decreased Levels of Antithrombin and Fibrinogen is the Target for Combination Therapy with Thrombomodulin Alfa and Antithrombin
by: Hideo Wada, et al.
Published: (2023-01-01)

Clinical features of patients with candidemia in sepsis
by: Akira Komori, et al.
Published: (2019-07-01)

Use of Antithrombin and Thrombomodulin in the Management of Disseminated Intravascular Coagulation in Patients with Acute Cholangitis
Published: (2013-05-01)

Recombinant thrombomodulin and recombinant antithrombin attenuate pulmonary endothelial glycocalyx degradation and neutrophil extracellular trap formation in ventilator-induced lung injury in the context of endotoxemia
by: Kenichiro Kikuchi, et al.
Published: (2024-09-01)

Coagulation phenotypes in sepsis and effects of recombinant human thrombomodulin: an analysis of three multicentre observational studies
by: Daisuke Kudo, et al.
Published: (2021-03-01)

Benefit Profile of Thrombomodulin Alfa Combined with Antithrombin Concentrate in Patients with Sepsis-Induced Disseminated Intravascular Coagulation
by: Atsushi Murao, et al.
Published: (2022-02-01)

Hyperoxia for sepsis and development of acute lung injury with increased mortality
by: Kazuma Yamakawa, et al.
Published: (2023-07-01)

Web-based application for predicting the potential target phenotype for recombinant human thrombomodulin therapy in patients with sepsis: analysis of three multicentre registries
by: Tadahiro Goto, et al.
Published: (2022-05-01)

Effects of combination therapy of antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation: a systematic review and meta-analysis
by: Takaaki Totoki, et al.
Published: (2024-01-01)

A randomized prospective comparison of the Baxter and Modified Brooke formulas for acute burn resuscitation
by: Daizoh Saitoh, et al.
Published: (2021-07-01)

Clinical Efficacy of Soluble Thrombomodulin, Tissue Plasminogen Activator Inhibitor complex, Thrombin-Antithrombin complex,α2-Plasmininhibitor-Plasmin complex in Pediatric Sepsis
by: Juanzhen Li, et al.
Published: (2022-05-01)

Decreased antithrombin activity in the early phase of trauma is strongly associated with extravascular leakage, but not with antithrombin consumption: a prospective observational study
by: Hironori Matsumoto, et al.
Published: (2018-08-01)

Effect of Recombinant Human Soluble Thrombomodulin on Coagulation-Related Variables in Patients With Sepsis-Induced Disseminated Intravascular Coagulation: A Retrospective Observational Study
by: Chieko Mitaka, et al.
Published: (2021-12-01)

Attempt for a Recombinant Thrombomodulin Alpha Treatment in a Rat Disseminated Intravascular Coagulation Model Using Yamakagashi (<i>Rhabdophis tigrinus</i>) Venom
by: Akihiko Yamamoto, et al.
Published: (2022-05-01)

Hirudins : antithrombin anticoagulants/
by: 245873 Stringer, Kathleen A., et al.

Genetic Analysis of a Pedigree With Antithrombin and Prothrombin Compound Mutations and Antithrombin Heterozygotes
by: Haiyue Zhang, et al.
Published: (2022-04-01)

The effect of antithrombin added to recombinant human-soluble thrombomodulin for severe community-acquired pneumonia-associated disseminated intravascular coagulation: a retrospective cohort study using a nationwide inpatient database
by: Jun Suzuki, et al.
Published: (2020-01-01)

Minimising the biases in the observational study of resuscitative endovascular balloon occlusion of the aorta: a research protocol for a prospective study analysed with propensity score matching with time-varying covariates
by: Yosuke Matsumura, et al.
Published: (2022-04-01)

Soluble Thrombomodulin and Major Orthopedic Surgery
by: Irina P. Antropova, et al.
Published: (2016-09-01)