Synaptic and functional alterations in the development of mutant huntingtin expressing hiPSC‐derived neurons

Synaptic and functional alterations in the development of mutant huntingtin expressing hiPSC‐derived neurons

Huntington’s disease (HD) is a monogenic disease that results in a combination of motor, psychiatric, and cognitive symptoms. It is caused by a CAG trinucleotide repeat expansion in the exon 1 of the huntingtin (HTT) gene, which results in the production of a mutant HTT protein (mHTT) with an extend...

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Bibliographic Details
Main Authors: Margarita C. Dinamarca, Laura Colombo, Natalia E. Tousiaki, Matthias Müller, Eline Pecho-Vrieseling
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
neurodevelopment
huntington (disease)
human iPS cell
synapsis formation
neurodegeneration
mutant huntingtin
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.916019/full

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