Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trials

Abstract Neurodegenerative disease is increasingly prevalent and remains without disease-modifying therapies. Engaging the right target, at the right disease stage, could be an important determinant of success. We annotated targets and eligibility criteria for 3238 neurodegenerative disease trials r...

Full description

Bibliographic Details
Main Authors: Meredith A. Mortberg, Sonia M. Vallabh, Eric Vallabh Minikel
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-21820-1