Synthesis of Rottlerone Analogues and Evaluation of Their α-Glucosidase and DPP-4 Dual Inhibitory and Glucose Consumption-Promoting Activity

Synthesis of Rottlerone Analogues and Evaluation of Their α-Glucosidase and DPP-4 Dual Inhibitory and Glucose Consumption-Promoting Activity

Our previous study found that desmethylxanthohumol (<b>1</b>) inhibited α-glucosidase in vitro. Recently, further investigations revealed that dehydrocyclodesmethylxanthohumol (<b>2</b>) and its dimer analogue rottlerone (<b>3</b>) exhibited more potent α-glucosid...

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Bibliographic Details
Main Authors: Yinan Zhang, Haibo Wang, Yan Wu, Xue Zhao, Zhihong Yan, Robert H. Dodd, Peng Yu, Kui Lu, Hua Sun
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
rottlerone
α-glucosidase inhibitor
DPP-4 inhibitor
inhibitory mechanism
glucose consumption
Online Access:https://www.mdpi.com/1420-3049/26/4/1024

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