Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor
Preterm birth (PTB) is the primary cause of neonatal mortality and long-term disabilities. The unknown mechanism behind PTB makes diagnosis difficult, yet early detection is necessary for controlling and averting related consequences. The primary focus of this work is to provide an overview of the k...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/11/2/161 |
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| author | Prashil Gondane Sakshi Kumbhakarn Pritiprasanna Maity Kausik Kapat |
| author_facet | Prashil Gondane Sakshi Kumbhakarn Pritiprasanna Maity Kausik Kapat |
| author_sort | Prashil Gondane |
| collection | DOAJ |
| description | Preterm birth (PTB) is the primary cause of neonatal mortality and long-term disabilities. The unknown mechanism behind PTB makes diagnosis difficult, yet early detection is necessary for controlling and averting related consequences. The primary focus of this work is to provide an overview of the known risk factors associated with preterm labor and the conventional and advanced procedures for early detection of PTB, including multi-omics and artificial intelligence/machine learning (AI/ML)- based approaches. It also discusses the principles of detecting various proteomic biomarkers based on lateral flow immunoassay and microfluidic chips, along with the commercially available point-of-care testing (POCT) devices and associated challenges. After briefing the therapeutic and preventive measures of PTB, this review summarizes with an outlook. |
| first_indexed | 2024-03-07T22:41:58Z |
| format | Article |
| id | doaj.art-b9a24cdd6f7147bb9fcca201688c68bc |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-07T22:41:58Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-b9a24cdd6f7147bb9fcca201688c68bc2024-02-23T15:07:58ZengMDPI AGBioengineering2306-53542024-02-0111216110.3390/bioengineering11020161Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm LaborPrashil Gondane0Sakshi Kumbhakarn1Pritiprasanna Maity2Kausik Kapat3Department of Medical Devices, National Institute of Pharmaceutical Education and Research Kolkata, 168, Maniktala Main Road, Kankurgachi, Kolkata 700054, IndiaDepartment of Medical Devices, National Institute of Pharmaceutical Education and Research Kolkata, 168, Maniktala Main Road, Kankurgachi, Kolkata 700054, IndiaDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Medical Devices, National Institute of Pharmaceutical Education and Research Kolkata, 168, Maniktala Main Road, Kankurgachi, Kolkata 700054, IndiaPreterm birth (PTB) is the primary cause of neonatal mortality and long-term disabilities. The unknown mechanism behind PTB makes diagnosis difficult, yet early detection is necessary for controlling and averting related consequences. The primary focus of this work is to provide an overview of the known risk factors associated with preterm labor and the conventional and advanced procedures for early detection of PTB, including multi-omics and artificial intelligence/machine learning (AI/ML)- based approaches. It also discusses the principles of detecting various proteomic biomarkers based on lateral flow immunoassay and microfluidic chips, along with the commercially available point-of-care testing (POCT) devices and associated challenges. After briefing the therapeutic and preventive measures of PTB, this review summarizes with an outlook.https://www.mdpi.com/2306-5354/11/2/161preterm birth (PTB)prelabor rupture of membrane (PROM)biomarkerslateral flow immunoassay (LFIA) devicemicrofluidicsmulti-omics |
| spellingShingle | Prashil Gondane Sakshi Kumbhakarn Pritiprasanna Maity Kausik Kapat Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor Bioengineering preterm birth (PTB) prelabor rupture of membrane (PROM) biomarkers lateral flow immunoassay (LFIA) device microfluidics multi-omics |
| title | Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor |
| title_full | Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor |
| title_fullStr | Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor |
| title_full_unstemmed | Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor |
| title_short | Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor |
| title_sort | recent advances and challenges in the early diagnosis and treatment of preterm labor |
| topic | preterm birth (PTB) prelabor rupture of membrane (PROM) biomarkers lateral flow immunoassay (LFIA) device microfluidics multi-omics |
| url | https://www.mdpi.com/2306-5354/11/2/161 |
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