FadA promotes DNA damage and progression of Fusobacterium nucleatum-induced colorectal cancer through up-regulation of chk2

FadA promotes DNA damage and progression of Fusobacterium nucleatum-induced colorectal cancer through up-regulation of chk2

Abstract Background Globally, colorectal cancer (CRC) affects more than 1 million people each year. In addition to non-modifiable and other environmental risk factors, Fusobacterium nucleatum infection has been linked to CRC recently. In this study, we explored mechanisms underlying the role of Fuso...

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Bibliographic Details
Main Authors: Pin Guo, Zibin Tian, Xinjuan Kong, Lin Yang, Xinzhi Shan, Bingzi Dong, Xueli Ding, Xue Jing, Chen Jiang, Na Jiang, Yanan Yu
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
Fusobacterium nucleatum
FadA, chk2
DNA damage
E-cadherin/β-catenin pathway
Online Access:http://link.springer.com/article/10.1186/s13046-020-01677-w

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