DHHC2 regulates fear memory formation, LTP, and AKAP150 signaling in the hippocampus

DHHC2 regulates fear memory formation, LTP, and AKAP150 signaling in the hippocampus

Summary: Palmitoyl acyltransferases (PATs) have been suggested to be involved in learning and memory. However, the underlying mechanisms have not yet been fully elucidated. Here, we found that the activity of DHHC2 was upregulated in the hippocampus after fear conditioning, and DHHC2 knockdown impai...

Full description

Bibliographic Details
Main Authors:	Meng-Die Li, Lu Wang, Yu-Qi Zheng, Dan-Hong Huang, Zhi-Xuan Xia, Jian-Min Liu, Dan Tian, Hui OuYang, Zi-Hao Wang, Zhen Huang, Xiao-Shan Lin, Xiao-Qian Zhu, Si-Ying Wang, Wei-Kai Chen, Shao-Wei Yang, Yue-Ling Zhao, Jia-An Liu, Zu-Cheng Shen
Format:	Article
Language:	English
Published:	Elsevier 2023-09-01
Series:	iScience
Subjects:	Biochemistry Molecular biology Neuroscience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223016383

Similar Items

AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP
by: Alicia M. Purkey, et al.
Published: (2018-10-01)

β-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca2+-permeable AMPA receptors
by: Jennifer L. Sanderson, et al.
Published: (2021-10-01)

The role of s-palmitoylation in neurological diseases: implication for zDHHC family
by: Dan Liao, et al.
Published: (2024-01-01)

The Hippocampus Is the Place to Be: Opioid Receptors and LTP
by: Thomas M. Sanderson, et al.
Published: (2019-07-01)

GluN2B S1303 phosphorylation by CaMKII or DAPK1: No indication for involvement in ischemia or LTP
by: Jonathan E. Tullis, et al.
Published: (2021-10-01)

Selective activation of AKAP150/TRPV1 in ventrolateral periaqueductal gray GABAergic neurons facilitates conditioned place aversion in male mice
by: Xiaohui Bai, et al.
Published: (2023-07-01)

Disinhibition-Mediated LTP in the Hippocampus is Synapse Specific
by: Jake eOrmond, et al.
Published: (2011-09-01)

AKAP150-mediated TRPV1 sensitization is disrupted by calcium/calmodulin
by: Shapiro Mark S, et al.
Published: (2011-05-01)

AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal
by: Xiaohui Bai, et al.
Published: (2023-11-01)

Structural Exploration on Palmitoyltransferase DHHC3 from <i>Homo sapiens</i>
by: Meng Tang, et al.
Published: (2022-07-01)

Selenoprotein K Increases Efficiency of DHHC6 Catalyzed Protein Palmitoylation by Stabilizing the Acyl-DHHC6 Intermediate
by: Gregory J. Fredericks, et al.
Published: (2017-12-01)

Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divide
by: Bliss Tim VP, et al.
Published: (2013-01-01)

Putative DHHC-cysteine-rich domain S-acyltransferase in plants.
by: Xiaowei Yuan, et al.
Published: (2013-01-01)

Substrate recruitment by zDHHC protein acyltransferases
by: Martin Ian P. Malgapo, et al.
Published: (2021-04-01)

Muscarinic acetylcholine receptor activation prevents disinhibition-mediated LTP in the Hippocampus
by: Petri eTakkala, et al.
Published: (2013-02-01)

A mitochondria-targeting dihydroartemisinin derivative as a reactive oxygen species -based immunogenic cell death inducer
by: Hong-Yang Zhao, et al.
Published: (2024-01-01)

DHHC21 deficiency attenuates renal dysfunction during septic injury
by: Xiaoyuan Yang, et al.
Published: (2021-05-01)

SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis
by: Meijing Wang, et al.
Published: (2022-04-01)

Antioxidant and Anticancer Functions of Protein Acyltransferase DHHC3
by: Chandan Sharma, et al.
Published: (2022-05-01)

The role of Phe150 in human voltage-gated proton channel
by: Xin Wu, et al.
Published: (2022-11-01)

PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus
by: Pojeong Park, et al.
Published: (2021-01-01)

Stress and Corticosteroids Modulate Muscarinic Long Term Potentiation (mLTP) in the Hippocampus
by: Efrat Shavit Stein, et al.
Published: (2017-09-01)

Intermittent administration of a leucine-deprived diet is able to intervene in type 2 diabetes in db/db mice
by: Siying Wei, et al.
Published: (2018-09-01)

Effect of Ketamine on LTP and NMDAR EPSC in Hippocampus of the Chronic Social Defeat Stress Mice Model of Depression
by: Yu Yang, et al.
Published: (2018-10-01)

Targeted degradation of zDHHC-PATs decreases substrate S-palmitoylation.
by: Mingjie Bai, et al.
Published: (2024-01-01)

Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampus.
by: Romberg, C, et al.
Published: (2009)

Identification of potato Lipid transfer protein gene family and expression verification of drought genes StLTP1 and StLTP7
by: Dan Wang, et al.
Published: (2023-03-01)

Unveiling the role of inorganic nanoparticles in Earth’s biochemical evolution through electron transfer dynamics
by: Xiao-Lan Huang
Published: (2024-05-01)

AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula
by: Sarah C. Simmons, et al.
Published: (2024-03-01)

An introduction to computational biochemistry /
by: 416648 Tsai, C. Stan
Published: (2002)

The Mechanism of Selective Recognition of Lipid Substrate by hDHHC20 Enzyme
by: Irina S. Panina, et al.
Published: (2022-11-01)

In vitro reconstitution of substrate S-acylation by the zDHHC family of protein acyltransferases
by: R. Elliot Murphy, et al.
Published: (2022-04-01)

Correction: Identification of DHHC Proteins and the Role of Protein S-palmitoylation in the Encystation Process.
Published: (2014-08-01)

Mutagenesis and characterization studies of E. Coli DNA-binding protein from starved cells (DPS)
by: Ang, Emmiline Xiao Wei
Published: (2010)

Angiotensin-(1-7) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas.
by: Hellner, K, et al.
Published: (2005)

Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus.
by: Jarod Swant, et al.
Published: (2010-06-01)

Main components of free organic carbon generated by obligate chemoautotrophic bacteria that inhibit their CO2 fixation
by: Saiwei Zhang, et al.
Published: (2022-12-01)

Dissociation between AKAP3 and PKARII promotes AKAP3 degradation in sperm capacitation.
by: Pnina Hillman, et al.
Published: (2013-01-01)

PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation.
by: Mariya Y Radeva, et al.
Published: (2014-01-01)

Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome
by: Richard S. Beard, et al.
Published: (2016-09-01)