Event-Related Potentials in ADHD Associated With Tuberous Sclerosis Complex: A Possible Biomarker of Symptoms Severity?
Background and Aim: Tuberous sclerosis complex (TSC) is associated with a high rate of attention deficit-hyperactivity disorder (ADHD), usually with more severe symptoms than in idiopathic cases. Event-related potentials have been used in idiopathic ADHD, and they have been proposed as a possible bi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00546/full |
| _version_ | 1818316174241300480 |
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| author | Romina Moavero Romina Moavero Sara Marciano Stefano Pro Donata De Stefano Federico Vigevano Paolo Curatolo Massimiliano Valeriani Massimiliano Valeriani |
| author_facet | Romina Moavero Romina Moavero Sara Marciano Stefano Pro Donata De Stefano Federico Vigevano Paolo Curatolo Massimiliano Valeriani Massimiliano Valeriani |
| author_sort | Romina Moavero |
| collection | DOAJ |
| description | Background and Aim: Tuberous sclerosis complex (TSC) is associated with a high rate of attention deficit-hyperactivity disorder (ADHD), usually with more severe symptoms than in idiopathic cases. Event-related potentials have been used in idiopathic ADHD, and they have been proposed as a possible biomarker of symptoms severity. Aim of this study was to investigate event-related potential (ERP) characteristics in patients with ADHD secondary to TSC, compared to patients with drug-naive idiopathic ADHD and healthy controls (HCs), to investigate whether (1) distinct clinical features can be due to different pathophysiological mechanisms, and (2) ERPs may reliably predict ADHD symptoms severity in TSC.Materials and Methods: We enrolled 13 patients with idiopathic ADHD (iADHD), 6 patients with ADHD associated with TSC (tscADHD), and 14 age-matched HCs (7–17 years). All of them underwent ERP recording, with mismatch negativity (MMN) preceding the P300 recording. All patients underwent neurocognitive evaluations.Results: Mismatch negativity latency was shorter in iADHD (P = 0.04) and tscADHD (P = 0.06) than in HC, with no difference between patients' groups. Mismatch negativity amplitude was significantly higher in patients (both iADHD and tscADHD) than in HC. The P300 amplitude was significantly lower in iADHD patients than in both tscADHD patients (P = 0.03) and HCs (P < 0.001). No difference was found between tscADHD patients and HCs (P = 0.2).Conclusion: While patients with iADHD present lower P300 amplitude than HC, in tscADHD patients P300 amplitude was not different from that in HC, suggesting that in TSC P300 amplitude does not really reflect symptom severity. |
| first_indexed | 2024-12-13T09:17:14Z |
| format | Article |
| id | doaj.art-b9a6a03bd5e24481816b1ffb55bb7f19 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-13T09:17:14Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-b9a6a03bd5e24481816b1ffb55bb7f192022-12-21T23:52:48ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-07-011110.3389/fneur.2020.00546544843Event-Related Potentials in ADHD Associated With Tuberous Sclerosis Complex: A Possible Biomarker of Symptoms Severity?Romina Moavero0Romina Moavero1Sara Marciano2Stefano Pro3Donata De Stefano4Federico Vigevano5Paolo Curatolo6Massimiliano Valeriani7Massimiliano Valeriani8Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University of Rome, Rome, ItalyChild Neurology Unit, Neuroscience and Neurorehabilitation Department, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyChild Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University of Rome, Rome, ItalyChild Neurology Unit, Neuroscience and Neurorehabilitation Department, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyChild Neurology Unit, Neuroscience and Neurorehabilitation Department, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyChild Neurology Unit, Neuroscience and Neurorehabilitation Department, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyChild Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University of Rome, Rome, ItalyChild Neurology Unit, Neuroscience and Neurorehabilitation Department, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyCenter for Sensory Motor Interaction Aalborg University, Aalborg, DenmarkBackground and Aim: Tuberous sclerosis complex (TSC) is associated with a high rate of attention deficit-hyperactivity disorder (ADHD), usually with more severe symptoms than in idiopathic cases. Event-related potentials have been used in idiopathic ADHD, and they have been proposed as a possible biomarker of symptoms severity. Aim of this study was to investigate event-related potential (ERP) characteristics in patients with ADHD secondary to TSC, compared to patients with drug-naive idiopathic ADHD and healthy controls (HCs), to investigate whether (1) distinct clinical features can be due to different pathophysiological mechanisms, and (2) ERPs may reliably predict ADHD symptoms severity in TSC.Materials and Methods: We enrolled 13 patients with idiopathic ADHD (iADHD), 6 patients with ADHD associated with TSC (tscADHD), and 14 age-matched HCs (7–17 years). All of them underwent ERP recording, with mismatch negativity (MMN) preceding the P300 recording. All patients underwent neurocognitive evaluations.Results: Mismatch negativity latency was shorter in iADHD (P = 0.04) and tscADHD (P = 0.06) than in HC, with no difference between patients' groups. Mismatch negativity amplitude was significantly higher in patients (both iADHD and tscADHD) than in HC. The P300 amplitude was significantly lower in iADHD patients than in both tscADHD patients (P = 0.03) and HCs (P < 0.001). No difference was found between tscADHD patients and HCs (P = 0.2).Conclusion: While patients with iADHD present lower P300 amplitude than HC, in tscADHD patients P300 amplitude was not different from that in HC, suggesting that in TSC P300 amplitude does not really reflect symptom severity.https://www.frontiersin.org/article/10.3389/fneur.2020.00546/fulltuberous sclerosis complexADHDERPMMNP300attention |
| spellingShingle | Romina Moavero Romina Moavero Sara Marciano Stefano Pro Donata De Stefano Federico Vigevano Paolo Curatolo Massimiliano Valeriani Massimiliano Valeriani Event-Related Potentials in ADHD Associated With Tuberous Sclerosis Complex: A Possible Biomarker of Symptoms Severity? Frontiers in Neurology tuberous sclerosis complex ADHD ERP MMN P300 attention |
| title | Event-Related Potentials in ADHD Associated With Tuberous Sclerosis Complex: A Possible Biomarker of Symptoms Severity? |
| title_full | Event-Related Potentials in ADHD Associated With Tuberous Sclerosis Complex: A Possible Biomarker of Symptoms Severity? |
| title_fullStr | Event-Related Potentials in ADHD Associated With Tuberous Sclerosis Complex: A Possible Biomarker of Symptoms Severity? |
| title_full_unstemmed | Event-Related Potentials in ADHD Associated With Tuberous Sclerosis Complex: A Possible Biomarker of Symptoms Severity? |
| title_short | Event-Related Potentials in ADHD Associated With Tuberous Sclerosis Complex: A Possible Biomarker of Symptoms Severity? |
| title_sort | event related potentials in adhd associated with tuberous sclerosis complex a possible biomarker of symptoms severity |
| topic | tuberous sclerosis complex ADHD ERP MMN P300 attention |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00546/full |
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