Continuous Modeling of Arterial Platelet Thrombus Formation Using a Spatial Adsorption Equation.
In this study, we considered a continuous model of platelet thrombus growth in an arteriole. A special model describing the adhesion of platelets in terms of their concentration was derived. The applications of the derived model are not restricted to only describing arterial platelet thrombus format...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0141068 |
| _version_ | 1818986393037176832 |
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| author | Evgenia S Babushkina Nikolay M Bessonov Fazoil I Ataullakhanov Mikhail A Panteleev |
| author_facet | Evgenia S Babushkina Nikolay M Bessonov Fazoil I Ataullakhanov Mikhail A Panteleev |
| author_sort | Evgenia S Babushkina |
| collection | DOAJ |
| description | In this study, we considered a continuous model of platelet thrombus growth in an arteriole. A special model describing the adhesion of platelets in terms of their concentration was derived. The applications of the derived model are not restricted to only describing arterial platelet thrombus formation; the model can also be applied to other similar adhesion processes. The model reproduces an auto-wave solution in the one-dimensional case; in the two-dimensional case, in which the surrounding flow is taken into account, the typical torch-like thrombus is reproduced. The thrombus shape and the growth velocity are determined by the model parameters. We demonstrate that the model captures the main properties of the thrombus growth behavior and provides us a better understanding of which mechanisms are important in the mechanical nature of the arterial thrombus growth. |
| first_indexed | 2024-12-20T18:50:04Z |
| format | Article |
| id | doaj.art-b9a8caca50334dd184fee010d27c2426 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T18:50:04Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b9a8caca50334dd184fee010d27c24262022-12-21T19:29:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011010e014106810.1371/journal.pone.0141068Continuous Modeling of Arterial Platelet Thrombus Formation Using a Spatial Adsorption Equation.Evgenia S BabushkinaNikolay M BessonovFazoil I AtaullakhanovMikhail A PanteleevIn this study, we considered a continuous model of platelet thrombus growth in an arteriole. A special model describing the adhesion of platelets in terms of their concentration was derived. The applications of the derived model are not restricted to only describing arterial platelet thrombus formation; the model can also be applied to other similar adhesion processes. The model reproduces an auto-wave solution in the one-dimensional case; in the two-dimensional case, in which the surrounding flow is taken into account, the typical torch-like thrombus is reproduced. The thrombus shape and the growth velocity are determined by the model parameters. We demonstrate that the model captures the main properties of the thrombus growth behavior and provides us a better understanding of which mechanisms are important in the mechanical nature of the arterial thrombus growth.https://doi.org/10.1371/journal.pone.0141068 |
| spellingShingle | Evgenia S Babushkina Nikolay M Bessonov Fazoil I Ataullakhanov Mikhail A Panteleev Continuous Modeling of Arterial Platelet Thrombus Formation Using a Spatial Adsorption Equation. PLoS ONE |
| title | Continuous Modeling of Arterial Platelet Thrombus Formation Using a Spatial Adsorption Equation. |
| title_full | Continuous Modeling of Arterial Platelet Thrombus Formation Using a Spatial Adsorption Equation. |
| title_fullStr | Continuous Modeling of Arterial Platelet Thrombus Formation Using a Spatial Adsorption Equation. |
| title_full_unstemmed | Continuous Modeling of Arterial Platelet Thrombus Formation Using a Spatial Adsorption Equation. |
| title_short | Continuous Modeling of Arterial Platelet Thrombus Formation Using a Spatial Adsorption Equation. |
| title_sort | continuous modeling of arterial platelet thrombus formation using a spatial adsorption equation |
| url | https://doi.org/10.1371/journal.pone.0141068 |
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