Monascus-fermented metabolites repressed amyloid β-peptide-induced neurotoxicity and inflammatory response in in vitro and in vivo studies
Monascus purpureus-produced monascin (MS) and ankaflavin (AK) have the potential to improve memory deficiency in Alzheimer's disease rat models; however, the mechanisms are still unclear. We aimed to investigate the effects and mechanisms of MS and AK on preventing Aβ40-induced oxidative stress...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-05-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623001093 |
| _version_ | 1797837117245620224 |
|---|---|
| author | Che-Wei Lin Pei-Ying Lin Ya-Wen Hsu Tzu-Ming Pan Chun-Lin Lee |
| author_facet | Che-Wei Lin Pei-Ying Lin Ya-Wen Hsu Tzu-Ming Pan Chun-Lin Lee |
| author_sort | Che-Wei Lin |
| collection | DOAJ |
| description | Monascus purpureus-produced monascin (MS) and ankaflavin (AK) have the potential to improve memory deficiency in Alzheimer's disease rat models; however, the mechanisms are still unclear. We aimed to investigate the effects and mechanisms of MS and AK on preventing Aβ40-induced oxidative stress and inflammatory response through in vitro and in vivo studies. Aβ40-treated PC-12 cells and intracerebroventricularly Aβ40-infused rats were used as the in vitro and in vivo models, respectively. MS and AK enhanced cell viability in Aβ40-treated PC-12 cells. Furthermore, the expression levels of oxidative and inflammatory factors, including COX-2, IL-1β, IL-6, iNOS, NF-κB, and TNF-α, were repressed by MS and AK treatment in the in vitro and in vivo models. The anti-oxidative and anti-inflammatory effects were the probable reasons for repressing Aβ40-induced p-tau protein expression, Aβ fibrils formation, neurotoxicity, and memory deficiency. |
| first_indexed | 2024-04-09T15:20:46Z |
| format | Article |
| id | doaj.art-b9a8f518ad024e1eb2dfca22e02a4b7a |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-09T15:20:46Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-b9a8f518ad024e1eb2dfca22e02a4b7a2023-04-29T14:48:21ZengElsevierJournal of Functional Foods1756-46462023-05-01104105509Monascus-fermented metabolites repressed amyloid β-peptide-induced neurotoxicity and inflammatory response in in vitro and in vivo studiesChe-Wei Lin0Pei-Ying Lin1Ya-Wen Hsu2Tzu-Ming Pan3Chun-Lin Lee4SunWay Biotech Co., Taipei, Taiwan, ROCSunWay Biotech Co., Taipei, Taiwan, ROC; Department of Life Science, National Taitung University, 369, Sec. 2, University Rd., Taitung 95092, Taiwan, ROCSunWay Biotech Co., Taipei, Taiwan, ROCSunWay Biotech Co., Taipei, Taiwan, ROC; Department of Biochemical Science and Technology, National Taiwan University, Taiwan, ROC; Corresponding authors at: Department of Life Science, National Taitung University, 369, Sec. 2, University Rd., Taitung 95092, Taiwan, ROC (C.-L. Lee). Department of Biochemical Science & Technology, National Taiwan University, Taiwan, ROC (T.-M. Pan).Department of Life Science, National Taitung University, 369, Sec. 2, University Rd., Taitung 95092, Taiwan, ROC; Corresponding authors at: Department of Life Science, National Taitung University, 369, Sec. 2, University Rd., Taitung 95092, Taiwan, ROC (C.-L. Lee). Department of Biochemical Science & Technology, National Taiwan University, Taiwan, ROC (T.-M. Pan).Monascus purpureus-produced monascin (MS) and ankaflavin (AK) have the potential to improve memory deficiency in Alzheimer's disease rat models; however, the mechanisms are still unclear. We aimed to investigate the effects and mechanisms of MS and AK on preventing Aβ40-induced oxidative stress and inflammatory response through in vitro and in vivo studies. Aβ40-treated PC-12 cells and intracerebroventricularly Aβ40-infused rats were used as the in vitro and in vivo models, respectively. MS and AK enhanced cell viability in Aβ40-treated PC-12 cells. Furthermore, the expression levels of oxidative and inflammatory factors, including COX-2, IL-1β, IL-6, iNOS, NF-κB, and TNF-α, were repressed by MS and AK treatment in the in vitro and in vivo models. The anti-oxidative and anti-inflammatory effects were the probable reasons for repressing Aβ40-induced p-tau protein expression, Aβ fibrils formation, neurotoxicity, and memory deficiency.http://www.sciencedirect.com/science/article/pii/S1756464623001093MonascinAnkaflavinAlzheimer's diseaseAmyloid β-peptideMonascusInflammatory |
| spellingShingle | Che-Wei Lin Pei-Ying Lin Ya-Wen Hsu Tzu-Ming Pan Chun-Lin Lee Monascus-fermented metabolites repressed amyloid β-peptide-induced neurotoxicity and inflammatory response in in vitro and in vivo studies Journal of Functional Foods Monascin Ankaflavin Alzheimer's disease Amyloid β-peptide Monascus Inflammatory |
| title | Monascus-fermented metabolites repressed amyloid β-peptide-induced neurotoxicity and inflammatory response in in vitro and in vivo studies |
| title_full | Monascus-fermented metabolites repressed amyloid β-peptide-induced neurotoxicity and inflammatory response in in vitro and in vivo studies |
| title_fullStr | Monascus-fermented metabolites repressed amyloid β-peptide-induced neurotoxicity and inflammatory response in in vitro and in vivo studies |
| title_full_unstemmed | Monascus-fermented metabolites repressed amyloid β-peptide-induced neurotoxicity and inflammatory response in in vitro and in vivo studies |
| title_short | Monascus-fermented metabolites repressed amyloid β-peptide-induced neurotoxicity and inflammatory response in in vitro and in vivo studies |
| title_sort | monascus fermented metabolites repressed amyloid β peptide induced neurotoxicity and inflammatory response in in vitro and in vivo studies |
| topic | Monascin Ankaflavin Alzheimer's disease Amyloid β-peptide Monascus Inflammatory |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623001093 |
| work_keys_str_mv | AT cheweilin monascusfermentedmetabolitesrepressedamyloidbpeptideinducedneurotoxicityandinflammatoryresponseininvitroandinvivostudies AT peiyinglin monascusfermentedmetabolitesrepressedamyloidbpeptideinducedneurotoxicityandinflammatoryresponseininvitroandinvivostudies AT yawenhsu monascusfermentedmetabolitesrepressedamyloidbpeptideinducedneurotoxicityandinflammatoryresponseininvitroandinvivostudies AT tzumingpan monascusfermentedmetabolitesrepressedamyloidbpeptideinducedneurotoxicityandinflammatoryresponseininvitroandinvivostudies AT chunlinlee monascusfermentedmetabolitesrepressedamyloidbpeptideinducedneurotoxicityandinflammatoryresponseininvitroandinvivostudies |