Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)?
Conjugation of drugs with biotin is a widely studied strategy for targeted drug delivery. The structure–activity relationship (SAR) studies through H3-biotin competition experiments conclude with the presence of a free carboxylic acid being essential for its uptake via the sodium-dependent multivita...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/14756366.2023.2276663 |
| _version_ | 1827123366776012800 |
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| author | Ravi Tripathi Anchala Guglani Rujuta Ghorpade Binghe Wang |
| author_facet | Ravi Tripathi Anchala Guglani Rujuta Ghorpade Binghe Wang |
| author_sort | Ravi Tripathi |
| collection | DOAJ |
| description | Conjugation of drugs with biotin is a widely studied strategy for targeted drug delivery. The structure–activity relationship (SAR) studies through H3-biotin competition experiments conclude with the presence of a free carboxylic acid being essential for its uptake via the sodium-dependent multivitamin transporter (SMVT, the major biotin transporter). However, biotin conjugation with a payload requires modification of the carboxylic acid to an amide or ester group. Then, there is the question as to how/whether the uptake of biotin conjugates goes through the SMVT. If not, then what is the mechanism? Herein, we present known uptake mechanisms of biotin and its applications reported in the literature. We also critically analyse possible uptake mechanism(s) of biotin conjugates to address the disconnect between the results from SMVT-based SAR and “biotin-facilitated” targeted drug delivery. We believe understanding the uptake mechanism of biotin conjugates is critical for their future applications and further development. |
| first_indexed | 2024-03-09T02:03:08Z |
| format | Article |
| id | doaj.art-b9a9f53c77814a6b840b49a26d930222 |
| institution | Directory Open Access Journal |
| issn | 1475-6366 1475-6374 |
| language | English |
| last_indexed | 2025-03-20T14:23:47Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Enzyme Inhibition and Medicinal Chemistry |
| spelling | doaj.art-b9a9f53c77814a6b840b49a26d9302222024-09-09T17:23:19ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742023-12-0138110.1080/14756366.2023.2276663Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)?Ravi Tripathi0Anchala Guglani1Rujuta Ghorpade2Binghe Wang3Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USADepartment of Biology, Georgia State University, Atlanta, GA, USADepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USADepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USAConjugation of drugs with biotin is a widely studied strategy for targeted drug delivery. The structure–activity relationship (SAR) studies through H3-biotin competition experiments conclude with the presence of a free carboxylic acid being essential for its uptake via the sodium-dependent multivitamin transporter (SMVT, the major biotin transporter). However, biotin conjugation with a payload requires modification of the carboxylic acid to an amide or ester group. Then, there is the question as to how/whether the uptake of biotin conjugates goes through the SMVT. If not, then what is the mechanism? Herein, we present known uptake mechanisms of biotin and its applications reported in the literature. We also critically analyse possible uptake mechanism(s) of biotin conjugates to address the disconnect between the results from SMVT-based SAR and “biotin-facilitated” targeted drug delivery. We believe understanding the uptake mechanism of biotin conjugates is critical for their future applications and further development.https://www.tandfonline.com/doi/10.1080/14756366.2023.2276663Biotintargeted drug deliverySMVTbiotin receptorSAR |
| spellingShingle | Ravi Tripathi Anchala Guglani Rujuta Ghorpade Binghe Wang Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)? Journal of Enzyme Inhibition and Medicinal Chemistry Biotin targeted drug delivery SMVT biotin receptor SAR |
| title | Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)? |
| title_full | Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)? |
| title_fullStr | Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)? |
| title_full_unstemmed | Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)? |
| title_short | Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)? |
| title_sort | biotin conjugates in targeted drug delivery is it mediated by a biotin transporter a yet to be identified receptor or an other unknown mechanism s |
| topic | Biotin targeted drug delivery SMVT biotin receptor SAR |
| url | https://www.tandfonline.com/doi/10.1080/14756366.2023.2276663 |
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