Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients
The present cross-sectional study consists of a comprehensive analysis of epidemiological, laboratory, and clinical characteristics of COVID-19 patients in relation to their immunogenetic profiles. We studied 125 COVID-19 patients comprising different stages of disease severity; non-hospitalized (mi...
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2021-09-01
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| author | Maria. G. Detsika Chara Giatra Vasiliki Kitsiou Edison Jahaj Theofilos Athanassiades Diamanto Kouniaki Stylianos E. Orfanos Ioanna Dimopoulou Maria Pagoni Katerina Tarassi Alexandra Tsirogianni Anastasia Kotanidou |
| author_facet | Maria. G. Detsika Chara Giatra Vasiliki Kitsiou Edison Jahaj Theofilos Athanassiades Diamanto Kouniaki Stylianos E. Orfanos Ioanna Dimopoulou Maria Pagoni Katerina Tarassi Alexandra Tsirogianni Anastasia Kotanidou |
| author_sort | Maria. G. Detsika |
| collection | DOAJ |
| description | The present cross-sectional study consists of a comprehensive analysis of epidemiological, laboratory, and clinical characteristics of COVID-19 patients in relation to their immunogenetic profiles. We studied 125 COVID-19 patients comprising different stages of disease severity; non-hospitalized (mild <i>n</i> = 69) and hospitalized (<i>n</i> = 56). Analysis of disease characteristics revealed no major differences between males and females of each group of patients while hospitalized patients were older and presented with comorbidities. A positive allele association was observed for HLA-DRB1*01 in total COVID-19 patients versus healthy controls. Subgrouping of COVID-19 patients in mild and hospitalized further identified a statistically significant increase in HLA-DRB1*01 in mild COVID-19 patients versus controls. The frequency of A*11, A*23, and DRB1*09 alleles was higher, while the frequency of C*12 was lower, in hospitalized patients versus healthy controls albeit with uncorrected statistical significance. The identification of specific allele associations may provide useful future markers for disease susceptibility in order to allow successful clinical management of COVID-19 patients. |
| first_indexed | 2024-03-10T06:27:14Z |
| format | Article |
| id | doaj.art-b9ac2060f376481ea410934ab14a440e |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T06:27:14Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-b9ac2060f376481ea410934ab14a440e2023-11-22T18:52:12ZengMDPI AGLife2075-17292021-09-011110101710.3390/life11101017Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 PatientsMaria. G. Detsika0Chara Giatra1Vasiliki Kitsiou2Edison Jahaj3Theofilos Athanassiades4Diamanto Kouniaki5Stylianos E. Orfanos6Ioanna Dimopoulou7Maria Pagoni8Katerina Tarassi9Alexandra Tsirogianni10Anastasia Kotanidou11Department of Critical Care Medicine & Pulmonary Services, School of Medicine, G.P. Livanos and M. Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, 10676 Athens, GreeceHematology Department, BMT Unit, “Evangelismos” Hospital, 10676 Athens, GreeceImmunology-Histocompatibility Department, “Evangelismos” Hospital, 10676 Athens, GreeceDepartment of Critical Care Medicine & Pulmonary Services, School of Medicine, G.P. Livanos and M. Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, 10676 Athens, GreeceImmunology-Histocompatibility Department, “Evangelismos” Hospital, 10676 Athens, GreeceImmunology-Histocompatibility Department, “Evangelismos” Hospital, 10676 Athens, GreeceDepartment of Critical Care Medicine & Pulmonary Services, School of Medicine, G.P. Livanos and M. Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, 10676 Athens, GreeceDepartment of Critical Care Medicine & Pulmonary Services, School of Medicine, G.P. Livanos and M. Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, 10676 Athens, GreeceHematology Department, BMT Unit, “Evangelismos” Hospital, 10676 Athens, GreeceImmunology-Histocompatibility Department, “Evangelismos” Hospital, 10676 Athens, GreeceImmunology-Histocompatibility Department, “Evangelismos” Hospital, 10676 Athens, GreeceDepartment of Critical Care Medicine & Pulmonary Services, School of Medicine, G.P. Livanos and M. Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, 10676 Athens, GreeceThe present cross-sectional study consists of a comprehensive analysis of epidemiological, laboratory, and clinical characteristics of COVID-19 patients in relation to their immunogenetic profiles. We studied 125 COVID-19 patients comprising different stages of disease severity; non-hospitalized (mild <i>n</i> = 69) and hospitalized (<i>n</i> = 56). Analysis of disease characteristics revealed no major differences between males and females of each group of patients while hospitalized patients were older and presented with comorbidities. A positive allele association was observed for HLA-DRB1*01 in total COVID-19 patients versus healthy controls. Subgrouping of COVID-19 patients in mild and hospitalized further identified a statistically significant increase in HLA-DRB1*01 in mild COVID-19 patients versus controls. The frequency of A*11, A*23, and DRB1*09 alleles was higher, while the frequency of C*12 was lower, in hospitalized patients versus healthy controls albeit with uncorrected statistical significance. The identification of specific allele associations may provide useful future markers for disease susceptibility in order to allow successful clinical management of COVID-19 patients.https://www.mdpi.com/2075-1729/11/10/1017SARS-CoV-2coronavirus disease 2019 (COVID-19)immunologyhuman leucocyte antigensimmunogenetics |
| spellingShingle | Maria. G. Detsika Chara Giatra Vasiliki Kitsiou Edison Jahaj Theofilos Athanassiades Diamanto Kouniaki Stylianos E. Orfanos Ioanna Dimopoulou Maria Pagoni Katerina Tarassi Alexandra Tsirogianni Anastasia Kotanidou Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients Life SARS-CoV-2 coronavirus disease 2019 (COVID-19) immunology human leucocyte antigens immunogenetics |
| title | Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients |
| title_full | Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients |
| title_fullStr | Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients |
| title_full_unstemmed | Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients |
| title_short | Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients |
| title_sort | demographic clinical and immunogenetic profiles of a greek cohort of covid 19 patients |
| topic | SARS-CoV-2 coronavirus disease 2019 (COVID-19) immunology human leucocyte antigens immunogenetics |
| url | https://www.mdpi.com/2075-1729/11/10/1017 |
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