Could Lowering Phytosterol Absorption as Part of Lipid-Lowering Therapy Have a Beneficial Effect on Residual Risk?
Plant sterols are molecules that are structurally similar to cholesterol and provided only as dietary sources (e.g., vegetables, fruits, nuts, cereals) since they cannot be synthesized by humans. Sterol-enriched diets (≥2 g/day) may decrease total and low-density lipoprotein cholesterol concentratio...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/2/145 |
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| author | Panagiotis Anagnostis Vasileios Kotsis Maciej Banach Dimitri P. Mikhailidis |
| author_facet | Panagiotis Anagnostis Vasileios Kotsis Maciej Banach Dimitri P. Mikhailidis |
| author_sort | Panagiotis Anagnostis |
| collection | DOAJ |
| description | Plant sterols are molecules that are structurally similar to cholesterol and provided only as dietary sources (e.g., vegetables, fruits, nuts, cereals) since they cannot be synthesized by humans. Sterol-enriched diets (≥2 g/day) may decrease total and low-density lipoprotein cholesterol concentrations by 5–10%, either alone or when added to statins, since they antagonize dietary cholesterol absorption in the intestine. On the other hand, increased serum phytosterol concentrations, (including when associated with sitosterolemia, a rare genetic defect) may contribute to atherosclerotic risk, although a threshold for such a role has not been established. Medications such as ezetimibe may effectively reduce cholesterol and phytosterol absorption. Whether the therapeutic approach associated with the reduction of phytosterol absorption is also translated into a reduction in a patient’s residual cardiovascular risk needs to be established. |
| first_indexed | 2024-03-11T08:26:34Z |
| format | Article |
| id | doaj.art-b9ac7abc352846cab5e8213d3f73e821 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T08:26:34Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-b9ac7abc352846cab5e8213d3f73e8212023-11-16T22:03:32ZengMDPI AGMetabolites2218-19892023-01-0113214510.3390/metabo13020145Could Lowering Phytosterol Absorption as Part of Lipid-Lowering Therapy Have a Beneficial Effect on Residual Risk?Panagiotis Anagnostis0Vasileios Kotsis1Maciej Banach2Dimitri P. Mikhailidis33rd Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, “Papageorgiou” General Hospital Thessaloniki, 56429 Thessaloniki, Greece3rd Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, “Papageorgiou” General Hospital Thessaloniki, 56429 Thessaloniki, GreeceDepartment of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), 90-419 Lodz, PolandDepartment of Clinical Biochemistry, Royal Free Hospital Campus, University College London Medical School, University College London (UCL), London NW3 2QG, UKPlant sterols are molecules that are structurally similar to cholesterol and provided only as dietary sources (e.g., vegetables, fruits, nuts, cereals) since they cannot be synthesized by humans. Sterol-enriched diets (≥2 g/day) may decrease total and low-density lipoprotein cholesterol concentrations by 5–10%, either alone or when added to statins, since they antagonize dietary cholesterol absorption in the intestine. On the other hand, increased serum phytosterol concentrations, (including when associated with sitosterolemia, a rare genetic defect) may contribute to atherosclerotic risk, although a threshold for such a role has not been established. Medications such as ezetimibe may effectively reduce cholesterol and phytosterol absorption. Whether the therapeutic approach associated with the reduction of phytosterol absorption is also translated into a reduction in a patient’s residual cardiovascular risk needs to be established.https://www.mdpi.com/2218-1989/13/2/145phytosterolssitosterolcampesterolstatinsezetimibe |
| spellingShingle | Panagiotis Anagnostis Vasileios Kotsis Maciej Banach Dimitri P. Mikhailidis Could Lowering Phytosterol Absorption as Part of Lipid-Lowering Therapy Have a Beneficial Effect on Residual Risk? Metabolites phytosterols sitosterol campesterol statins ezetimibe |
| title | Could Lowering Phytosterol Absorption as Part of Lipid-Lowering Therapy Have a Beneficial Effect on Residual Risk? |
| title_full | Could Lowering Phytosterol Absorption as Part of Lipid-Lowering Therapy Have a Beneficial Effect on Residual Risk? |
| title_fullStr | Could Lowering Phytosterol Absorption as Part of Lipid-Lowering Therapy Have a Beneficial Effect on Residual Risk? |
| title_full_unstemmed | Could Lowering Phytosterol Absorption as Part of Lipid-Lowering Therapy Have a Beneficial Effect on Residual Risk? |
| title_short | Could Lowering Phytosterol Absorption as Part of Lipid-Lowering Therapy Have a Beneficial Effect on Residual Risk? |
| title_sort | could lowering phytosterol absorption as part of lipid lowering therapy have a beneficial effect on residual risk |
| topic | phytosterols sitosterol campesterol statins ezetimibe |
| url | https://www.mdpi.com/2218-1989/13/2/145 |
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