HER2 in Metastatic Colorectal Cancer: Pathology, Somatic Alterations, and Perspectives for Novel Therapeutic Schemes

HER2 in Metastatic Colorectal Cancer: Pathology, Somatic Alterations, and Perspectives for Novel Therapeutic Schemes

HER2 is an emerging biomarker in colorectal cancer (CRC). This oncogene plays an essential role in regulating cell proliferation, differentiation, migration, and, more in general, tumorigenesis and tumor progression. The most frequent types of HER2 alterations in CRC include gene amplification and m...

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Bibliographic Details
Main Authors: Mariia Ivanova, Konstantinos Venetis, Elena Guerini-Rocco, Luca Bottiglieri, Mauro Giuseppe Mastropasqua, Ornella Garrone, Nicola Fusco, Michele Ghidini
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Life
Subjects:
HER2
colorectal cancer
pathology
biomarkers
targeted therapy
Online Access:https://www.mdpi.com/2075-1729/12/9/1403

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