Synthesis and antimicrobial evaluation of novel 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid
A series of 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid (6a–s) were synthesized by cyclization of carboxylic acid group of 2-(2-methoxy-4-(3-oxo-3-substituted phenylprop-1-enyl)phenoxy) acetic acid (4a–s) with thiosemicarbazide in the presence of POCl3 or PPA. The stru...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-11-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535212000305 |
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| author | Malleshappa N. Noolvi Harun M. Patel Sarita Kamboj Swaranjit Singh Cameotra |
| author_facet | Malleshappa N. Noolvi Harun M. Patel Sarita Kamboj Swaranjit Singh Cameotra |
| author_sort | Malleshappa N. Noolvi |
| collection | DOAJ |
| description | A series of 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid (6a–s) were synthesized by cyclization of carboxylic acid group of 2-(2-methoxy-4-(3-oxo-3-substituted phenylprop-1-enyl)phenoxy) acetic acid (4a–s) with thiosemicarbazide in the presence of POCl3 or PPA. The structures of the compounds were confirmed by IR, 1H NMR and mass analysis. All the compounds have been evaluated in vitro for their antimicrobial activities against several strains of microbes and show significant activity. |
| first_indexed | 2024-12-11T07:48:31Z |
| format | Article |
| id | doaj.art-b9b03707b7ca4731a642fa0fdbae833d |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-11T07:48:31Z |
| publishDate | 2016-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-b9b03707b7ca4731a642fa0fdbae833d2022-12-22T01:15:24ZengElsevierArabian Journal of Chemistry1878-53522016-11-019S2S1283S128910.1016/j.arabjc.2012.02.003Synthesis and antimicrobial evaluation of novel 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acidMalleshappa N. Noolvi0Harun M. Patel1Sarita Kamboj2Swaranjit Singh Cameotra3Department of Pharmaceutical Chemistry, Shree Dhanvantary Pharmacy College, Kim (Surat) 394110, Gujarat, IndiaDepartment of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur (Dhule) 425405, Maharashtra, IndiaDepartment of Pharmaceutical Chemistry, ASBASJSM College of Pharmacy, Bela (Ropar) 140111, Punjab, IndiaEnvironmental Biotechnology & Microbial Biochemistry, Institute of Microbial Technology, Chandigarh, IndiaA series of 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid (6a–s) were synthesized by cyclization of carboxylic acid group of 2-(2-methoxy-4-(3-oxo-3-substituted phenylprop-1-enyl)phenoxy) acetic acid (4a–s) with thiosemicarbazide in the presence of POCl3 or PPA. The structures of the compounds were confirmed by IR, 1H NMR and mass analysis. All the compounds have been evaluated in vitro for their antimicrobial activities against several strains of microbes and show significant activity.http://www.sciencedirect.com/science/article/pii/S1878535212000305Phenoxyacetic acid1,3,4-ThiadiazoleAntimicrobial |
| spellingShingle | Malleshappa N. Noolvi Harun M. Patel Sarita Kamboj Swaranjit Singh Cameotra Synthesis and antimicrobial evaluation of novel 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid Arabian Journal of Chemistry Phenoxyacetic acid 1,3,4-Thiadiazole Antimicrobial |
| title | Synthesis and antimicrobial evaluation of novel 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid |
| title_full | Synthesis and antimicrobial evaluation of novel 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid |
| title_fullStr | Synthesis and antimicrobial evaluation of novel 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid |
| title_full_unstemmed | Synthesis and antimicrobial evaluation of novel 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid |
| title_short | Synthesis and antimicrobial evaluation of novel 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid |
| title_sort | synthesis and antimicrobial evaluation of novel 1 3 4 thiadiazole derivatives of 2 4 formyl 2 methoxyphenoxy acetic acid |
| topic | Phenoxyacetic acid 1,3,4-Thiadiazole Antimicrobial |
| url | http://www.sciencedirect.com/science/article/pii/S1878535212000305 |
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