Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways
Lipoxins (LXs) have attracted widespread attention as a class of anti-inflammatory lipid mediators that are produced endogenously by the organism. LXs are arachidonic acid (ARA) derivatives that include four different structures: lipoxin A4 (LXA4), lipoxin B4 (LXB4), and the aspirin-induced differen...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/17/13282 |
| _version_ | 1797582476773687296 |
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| author | Junxi Chi Jiahao Cheng Shang Wang Cheng Li Ming Chen |
| author_facet | Junxi Chi Jiahao Cheng Shang Wang Cheng Li Ming Chen |
| author_sort | Junxi Chi |
| collection | DOAJ |
| description | Lipoxins (LXs) have attracted widespread attention as a class of anti-inflammatory lipid mediators that are produced endogenously by the organism. LXs are arachidonic acid (ARA) derivatives that include four different structures: lipoxin A4 (LXA4), lipoxin B4 (LXB4), and the aspirin-induced differential isomers 15-epi-LXA4 and 15-epi-LXB4. Because of their unique biological activity of reducing inflammation in the body, LXs have great potential for neuroprotection, anti-inflammatory treatment of COVID-19, and other related diseases. The synthesis of LXs in vivo is achieved through the action of lipoxygenase (LO). As a kind of important enzyme, LO plays a major role in the physiological processes of living organisms in mammals and functions in some bacteria and fungi. This suggests new options for the synthesis of LXs in vitro. Meanwhile, there are other chemical and biochemical methods to synthesize LXs. In this review, the recent progress on physiological activity and synthetic pathways of LXs is summarized, and new insights into the synthesis of LXs in vitro are provided. |
| first_indexed | 2024-03-10T23:21:49Z |
| format | Article |
| id | doaj.art-b9b044f61e034cedbb9f6381883b71d5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:21:49Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b9b044f61e034cedbb9f6381883b71d52023-11-19T08:15:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124171328210.3390/ijms241713282Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic PathwaysJunxi Chi0Jiahao Cheng1Shang Wang2Cheng Li3Ming Chen4School of Biological Engineering, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Biological Engineering, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Biological Engineering, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Biological Engineering, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Biological Engineering, Dalian Polytechnic University, Dalian 116034, ChinaLipoxins (LXs) have attracted widespread attention as a class of anti-inflammatory lipid mediators that are produced endogenously by the organism. LXs are arachidonic acid (ARA) derivatives that include four different structures: lipoxin A4 (LXA4), lipoxin B4 (LXB4), and the aspirin-induced differential isomers 15-epi-LXA4 and 15-epi-LXB4. Because of their unique biological activity of reducing inflammation in the body, LXs have great potential for neuroprotection, anti-inflammatory treatment of COVID-19, and other related diseases. The synthesis of LXs in vivo is achieved through the action of lipoxygenase (LO). As a kind of important enzyme, LO plays a major role in the physiological processes of living organisms in mammals and functions in some bacteria and fungi. This suggests new options for the synthesis of LXs in vitro. Meanwhile, there are other chemical and biochemical methods to synthesize LXs. In this review, the recent progress on physiological activity and synthetic pathways of LXs is summarized, and new insights into the synthesis of LXs in vitro are provided.https://www.mdpi.com/1422-0067/24/17/13282lipoxinsanti-inflammatory mediatorsbiological activitysynthetic pathwayslipoxygenase |
| spellingShingle | Junxi Chi Jiahao Cheng Shang Wang Cheng Li Ming Chen Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways International Journal of Molecular Sciences lipoxins anti-inflammatory mediators biological activity synthetic pathways lipoxygenase |
| title | Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways |
| title_full | Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways |
| title_fullStr | Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways |
| title_full_unstemmed | Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways |
| title_short | Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways |
| title_sort | promising anti inflammatory tools biomedical efficacy of lipoxins and their synthetic pathways |
| topic | lipoxins anti-inflammatory mediators biological activity synthetic pathways lipoxygenase |
| url | https://www.mdpi.com/1422-0067/24/17/13282 |
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