Low Antioxidant Status of Serum Uric Acid, Bilirubin, Albumin, and Creatinine in Patients With Benign Paroxysmal Positional Vertigo
Objective: To investigate the roles of serum uric acid (UA), bilirubin (BIL), albumin (ALB), and creatinine (CRE) as major intravascular antioxidants, in benign paroxysmal positional vertigo (BPPV).Methods: The serum levels of UA, BIL, ALB, and CRE were retrospectively analyzed in 70 patients with n...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-11-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2020.601695/full |
| _version_ | 1818436724239368192 |
|---|---|
| author | Ke-Hang Xie Ling-Ling Liu Chu-Yin Su Xiao-Feng Huang Bao-Xing Wu Run-Ni Liu Hua Li Qing-Qing Chen Jia-Sheng He Yong-Kun Ruan |
| author_facet | Ke-Hang Xie Ling-Ling Liu Chu-Yin Su Xiao-Feng Huang Bao-Xing Wu Run-Ni Liu Hua Li Qing-Qing Chen Jia-Sheng He Yong-Kun Ruan |
| author_sort | Ke-Hang Xie |
| collection | DOAJ |
| description | Objective: To investigate the roles of serum uric acid (UA), bilirubin (BIL), albumin (ALB), and creatinine (CRE) as major intravascular antioxidants, in benign paroxysmal positional vertigo (BPPV).Methods: The serum levels of UA, BIL, ALB, and CRE were retrospectively analyzed in 70 patients with new-onset idiopathic BPPV and 140 age- and sex-matched healthy controls (HCs).Results: Serum UA, BIL, ALB, and CRE levels were significantly lower in the BPPV group than the HC group. Furthermore, serum levels of BIL and ALB were significantly lower in the BPPV group when compared by sex. Multiple stepwise logistic regression revealed that a reduction in serum ALB was independently related to BPPV (odds ratio = 0.688; 95% confidence interval = 0.607– 0.780). Receiver operating characteristic analyses revealed a cut-off value of 45.15 g/L for ALB with a sensitivity of 74.29% (62.97– 83.07%) and specificity of 73.57% (65.71– 80.18%).Conclusions: Serum levels of UA, BIL, ALB, and CRE were lower in BPPV patients, indicating a lower antioxidant status. Furthermore, a reduction in serum ALB was independently associated with BPPV. These results provide insights into the possible roles of oxidative stress in the pathogenesis of BPPV. |
| first_indexed | 2024-12-14T17:13:19Z |
| format | Article |
| id | doaj.art-b9b1783f1d9d4d798f5fce65069456ed |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T17:13:19Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-b9b1783f1d9d4d798f5fce65069456ed2022-12-21T22:53:30ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-11-011110.3389/fneur.2020.601695601695Low Antioxidant Status of Serum Uric Acid, Bilirubin, Albumin, and Creatinine in Patients With Benign Paroxysmal Positional VertigoKe-Hang Xie0Ling-Ling Liu1Chu-Yin Su2Xiao-Feng Huang3Bao-Xing Wu4Run-Ni Liu5Hua Li6Qing-Qing Chen7Jia-Sheng He8Yong-Kun Ruan9Department of Neurology, Zhuhai City Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, ChinaDepartment of Nephrology, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, ChinaDepartment of Neurology, Zhuhai City Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, ChinaDepartment of Neurology, Zhuhai City Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, ChinaDepartment of Neurology, Zhuhai City Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, ChinaDepartment of Neurology, Zhuhai City Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, ChinaDepartment of Neurology, Zhuhai City Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, ChinaDepartment of Neurology, Zhuhai City Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, ChinaDepartment of Neurology, Zhuhai City Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, ChinaDepartment of Neurology, Zhuhai City Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, ChinaObjective: To investigate the roles of serum uric acid (UA), bilirubin (BIL), albumin (ALB), and creatinine (CRE) as major intravascular antioxidants, in benign paroxysmal positional vertigo (BPPV).Methods: The serum levels of UA, BIL, ALB, and CRE were retrospectively analyzed in 70 patients with new-onset idiopathic BPPV and 140 age- and sex-matched healthy controls (HCs).Results: Serum UA, BIL, ALB, and CRE levels were significantly lower in the BPPV group than the HC group. Furthermore, serum levels of BIL and ALB were significantly lower in the BPPV group when compared by sex. Multiple stepwise logistic regression revealed that a reduction in serum ALB was independently related to BPPV (odds ratio = 0.688; 95% confidence interval = 0.607– 0.780). Receiver operating characteristic analyses revealed a cut-off value of 45.15 g/L for ALB with a sensitivity of 74.29% (62.97– 83.07%) and specificity of 73.57% (65.71– 80.18%).Conclusions: Serum levels of UA, BIL, ALB, and CRE were lower in BPPV patients, indicating a lower antioxidant status. Furthermore, a reduction in serum ALB was independently associated with BPPV. These results provide insights into the possible roles of oxidative stress in the pathogenesis of BPPV.https://www.frontiersin.org/articles/10.3389/fneur.2020.601695/fullbenign paroxysmal positional vertigoantioxidant statusuric acidbilirubinalbumincreatinine |
| spellingShingle | Ke-Hang Xie Ling-Ling Liu Chu-Yin Su Xiao-Feng Huang Bao-Xing Wu Run-Ni Liu Hua Li Qing-Qing Chen Jia-Sheng He Yong-Kun Ruan Low Antioxidant Status of Serum Uric Acid, Bilirubin, Albumin, and Creatinine in Patients With Benign Paroxysmal Positional Vertigo Frontiers in Neurology benign paroxysmal positional vertigo antioxidant status uric acid bilirubin albumin creatinine |
| title | Low Antioxidant Status of Serum Uric Acid, Bilirubin, Albumin, and Creatinine in Patients With Benign Paroxysmal Positional Vertigo |
| title_full | Low Antioxidant Status of Serum Uric Acid, Bilirubin, Albumin, and Creatinine in Patients With Benign Paroxysmal Positional Vertigo |
| title_fullStr | Low Antioxidant Status of Serum Uric Acid, Bilirubin, Albumin, and Creatinine in Patients With Benign Paroxysmal Positional Vertigo |
| title_full_unstemmed | Low Antioxidant Status of Serum Uric Acid, Bilirubin, Albumin, and Creatinine in Patients With Benign Paroxysmal Positional Vertigo |
| title_short | Low Antioxidant Status of Serum Uric Acid, Bilirubin, Albumin, and Creatinine in Patients With Benign Paroxysmal Positional Vertigo |
| title_sort | low antioxidant status of serum uric acid bilirubin albumin and creatinine in patients with benign paroxysmal positional vertigo |
| topic | benign paroxysmal positional vertigo antioxidant status uric acid bilirubin albumin creatinine |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2020.601695/full |
| work_keys_str_mv | AT kehangxie lowantioxidantstatusofserumuricacidbilirubinalbuminandcreatinineinpatientswithbenignparoxysmalpositionalvertigo AT linglingliu lowantioxidantstatusofserumuricacidbilirubinalbuminandcreatinineinpatientswithbenignparoxysmalpositionalvertigo AT chuyinsu lowantioxidantstatusofserumuricacidbilirubinalbuminandcreatinineinpatientswithbenignparoxysmalpositionalvertigo AT xiaofenghuang lowantioxidantstatusofserumuricacidbilirubinalbuminandcreatinineinpatientswithbenignparoxysmalpositionalvertigo AT baoxingwu lowantioxidantstatusofserumuricacidbilirubinalbuminandcreatinineinpatientswithbenignparoxysmalpositionalvertigo AT runniliu lowantioxidantstatusofserumuricacidbilirubinalbuminandcreatinineinpatientswithbenignparoxysmalpositionalvertigo AT huali lowantioxidantstatusofserumuricacidbilirubinalbuminandcreatinineinpatientswithbenignparoxysmalpositionalvertigo AT qingqingchen lowantioxidantstatusofserumuricacidbilirubinalbuminandcreatinineinpatientswithbenignparoxysmalpositionalvertigo AT jiashenghe lowantioxidantstatusofserumuricacidbilirubinalbuminandcreatinineinpatientswithbenignparoxysmalpositionalvertigo AT yongkunruan lowantioxidantstatusofserumuricacidbilirubinalbuminandcreatinineinpatientswithbenignparoxysmalpositionalvertigo |