Effect of Levothyroxine on Older Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis
BackgroundSubclinical hypothyroidism (SCH) is usually treated with levothyroxine, but there is controversy as to whether SCH should be treated, especially for older patients. The aim of the systematic review and meta-analysis was to evaluate whether levothyroxine has a beneficial or harmful effect o...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.913749/full |
| _version_ | 1811292433106862080 |
|---|---|
| author | Chunyan Zhao Yueqi Wang Liu Xiao Lin Li |
| author_facet | Chunyan Zhao Yueqi Wang Liu Xiao Lin Li |
| author_sort | Chunyan Zhao |
| collection | DOAJ |
| description | BackgroundSubclinical hypothyroidism (SCH) is usually treated with levothyroxine, but there is controversy as to whether SCH should be treated, especially for older patients. The aim of the systematic review and meta-analysis was to evaluate whether levothyroxine has a beneficial or harmful effect on older patients with SCH.MethodsDatabases including PubMed, Embase, Cochrane Library, Web of Science, Wanfang, Weipu and China National Knowledge Infrastructure were searched from inception until December 21, 2021. Subjects must be diagnosed with SCH, and older than or equal to 60 years of age. Interventions should be thyroid hormone therapy (e.g. levothyroxine). The literature was independently screened by 2 researchers. Statistical analysis was performed using RevMan5.3 software.ResultsA total of 13 articles were included. Meta-analysis results showed that in older SCH patients, levothyroxine can significantly reduce cholesterol (TC) (p < 0.00001), triglyceride (TG) (p < 0.00001), low-density lipoprotein cholesterol (LDL-C) (p = 0.03) and apolipoprotein B (ApoB) (p < 0.00001). In addition, levothyroxine had no significant effect on bone mineral density, fatigue, hypothyroidism symptoms, quality of life, BMI, cognitive function, depression, blood pressure, etc. in older SCH patients, and also did not significantly increase the incidence of adverse events.ConclusionsAmong older SCH patients, levothyroxine treatment may reduce TC, TG, LDL-C, and ApoB. |
| first_indexed | 2024-04-13T04:45:19Z |
| format | Article |
| id | doaj.art-b9b195d8ba1140b4a9525ba997f84905 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T04:45:19Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-b9b195d8ba1140b4a9525ba997f849052022-12-22T03:01:52ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-07-011310.3389/fendo.2022.913749913749Effect of Levothyroxine on Older Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-AnalysisChunyan ZhaoYueqi WangLiu XiaoLin LiBackgroundSubclinical hypothyroidism (SCH) is usually treated with levothyroxine, but there is controversy as to whether SCH should be treated, especially for older patients. The aim of the systematic review and meta-analysis was to evaluate whether levothyroxine has a beneficial or harmful effect on older patients with SCH.MethodsDatabases including PubMed, Embase, Cochrane Library, Web of Science, Wanfang, Weipu and China National Knowledge Infrastructure were searched from inception until December 21, 2021. Subjects must be diagnosed with SCH, and older than or equal to 60 years of age. Interventions should be thyroid hormone therapy (e.g. levothyroxine). The literature was independently screened by 2 researchers. Statistical analysis was performed using RevMan5.3 software.ResultsA total of 13 articles were included. Meta-analysis results showed that in older SCH patients, levothyroxine can significantly reduce cholesterol (TC) (p < 0.00001), triglyceride (TG) (p < 0.00001), low-density lipoprotein cholesterol (LDL-C) (p = 0.03) and apolipoprotein B (ApoB) (p < 0.00001). In addition, levothyroxine had no significant effect on bone mineral density, fatigue, hypothyroidism symptoms, quality of life, BMI, cognitive function, depression, blood pressure, etc. in older SCH patients, and also did not significantly increase the incidence of adverse events.ConclusionsAmong older SCH patients, levothyroxine treatment may reduce TC, TG, LDL-C, and ApoB.https://www.frontiersin.org/articles/10.3389/fendo.2022.913749/fullolderlevothyroxinesubclinical hypothyroidismcholesteroltriglyceridelow-density lipoprotein cholesterol |
| spellingShingle | Chunyan Zhao Yueqi Wang Liu Xiao Lin Li Effect of Levothyroxine on Older Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis Frontiers in Endocrinology older levothyroxine subclinical hypothyroidism cholesterol triglyceride low-density lipoprotein cholesterol |
| title | Effect of Levothyroxine on Older Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis |
| title_full | Effect of Levothyroxine on Older Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis |
| title_fullStr | Effect of Levothyroxine on Older Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effect of Levothyroxine on Older Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis |
| title_short | Effect of Levothyroxine on Older Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis |
| title_sort | effect of levothyroxine on older patients with subclinical hypothyroidism a systematic review and meta analysis |
| topic | older levothyroxine subclinical hypothyroidism cholesterol triglyceride low-density lipoprotein cholesterol |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.913749/full |
| work_keys_str_mv | AT chunyanzhao effectoflevothyroxineonolderpatientswithsubclinicalhypothyroidismasystematicreviewandmetaanalysis AT yueqiwang effectoflevothyroxineonolderpatientswithsubclinicalhypothyroidismasystematicreviewandmetaanalysis AT liuxiao effectoflevothyroxineonolderpatientswithsubclinicalhypothyroidismasystematicreviewandmetaanalysis AT linli effectoflevothyroxineonolderpatientswithsubclinicalhypothyroidismasystematicreviewandmetaanalysis |