Overexpression of Mechano-Growth Factor Modulates Inflammatory Cytokine Expression and Macrophage Resolution in Skeletal Muscle Injury

Overexpression of Mechano-Growth Factor Modulates Inflammatory Cytokine Expression and Macrophage Resolution in Skeletal Muscle Injury

In muscle regeneration, infiltrating myeloid cells, such as macrophages mediate muscle inflammation by releasing key soluble factors. One such factor, insulin-like growth factor 1 (IGF-1), suppresses inflammatory cytokine expression and mediates macrophage polarization to anti-inflammatory phenotype...

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Bibliographic Details
Main Authors: Keng-Ting Sun, Kwok-Kuen Cheung, Shannon W. N. Au, Simon S. Yeung, Ella W. Yeung
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
skeletal muscle injury
inflammation
muscle regeneration
insulin-like growth factor 1
mechano-growth factor
myeloid cells
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00999/full

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