Serum biomarkers for arterial calcification in humans: A systematic review
Aim: To clarify the role of mediators of ectopic mineralization as biomarkers for arterial calcifications. Methods: MEDLINE and Embase were searched for relevant literature, until January 4th 2022. The investigated biomarkers were: calcium, phosphate, parathyroid hormone, vitamin D, pyrophosphate, o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Bone Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352187222004338 |
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| author | Nienke M.S. Golüke Marit A. Schoffelmeer Annemarieke De Jonghe Mariëlle H. Emmelot-Vonk Pim A. De Jong Huiberdina L. Koek |
| author_facet | Nienke M.S. Golüke Marit A. Schoffelmeer Annemarieke De Jonghe Mariëlle H. Emmelot-Vonk Pim A. De Jong Huiberdina L. Koek |
| author_sort | Nienke M.S. Golüke |
| collection | DOAJ |
| description | Aim: To clarify the role of mediators of ectopic mineralization as biomarkers for arterial calcifications. Methods: MEDLINE and Embase were searched for relevant literature, until January 4th 2022. The investigated biomarkers were: calcium, phosphate, parathyroid hormone, vitamin D, pyrophosphate, osteoprotegerin, receptor activator of nuclear factor-kappa B ligand (RANKL), fibroblast growth factor-23 (FGF-23), Klotho, osteopontin, osteocalcin, Matrix Gla protein (MGP) and its inactive forms and vitamin K. Studies solely performed in patients with kidney insufficiency or diabetes mellitus were excluded. Results: After screening of 8985 articles, a total of 129 articles were included in this systematic review. For all biomarkers included in this review, the results were variable and more than half of the studies for each specific biomarker had a non-significant result. Also, the overall quality of the included studies was low, partly as a result of the mostly cross-sectional study designs. The largest body of evidence is available for phosphate, osteopontin and FGF-23, as a little over half of the studies showed a significant, positive association. Firm statements for these biomarkers cannot be drawn, as the number of studies was limited and hampered by residual confounding or had non-significant results. The associations of the other mediators of ectopic mineralization with arterial calcifications were not clear. Conclusion: Associations between biomarkers of ectopic mineralization and arterial calcification are variable in the published literature. Future longitudinal studies differentiating medial and intimal calcification could add to the knowledge of biomarkers and mechanisms of arterial calcifications. |
| first_indexed | 2024-04-13T05:50:40Z |
| format | Article |
| id | doaj.art-b9b58f58981d4748b473a403ffbfde78 |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2024-04-13T05:50:40Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-b9b58f58981d4748b473a403ffbfde782022-12-22T02:59:47ZengElsevierBone Reports2352-18722022-12-0117101599Serum biomarkers for arterial calcification in humans: A systematic reviewNienke M.S. Golüke0Marit A. Schoffelmeer1Annemarieke De Jonghe2Mariëlle H. Emmelot-Vonk3Pim A. De Jong4Huiberdina L. Koek5University Medical Center Utrecht, Department of Geriatrics, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands; Tergooi Hospitals, Department of Geriatrics, Rijksstraatweg 1, 1261 AN Blaricum, the Netherlands; Corresponding author at: Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.University Medical Center Utrecht, Department of Geriatrics, Heidelberglaan 100, 3584 CX Utrecht, the NetherlandsTergooi Hospitals, Department of Geriatrics, Rijksstraatweg 1, 1261 AN Blaricum, the NetherlandsUniversity Medical Center Utrecht, Department of Geriatrics, Heidelberglaan 100, 3584 CX Utrecht, the NetherlandsUniversity Medical Center Utrecht, Department of Radiology, Heidelberglaan 100, 3584 CX Utrecht, the NetherlandsUniversity Medical Center Utrecht, Department of Geriatrics, Heidelberglaan 100, 3584 CX Utrecht, the NetherlandsAim: To clarify the role of mediators of ectopic mineralization as biomarkers for arterial calcifications. Methods: MEDLINE and Embase were searched for relevant literature, until January 4th 2022. The investigated biomarkers were: calcium, phosphate, parathyroid hormone, vitamin D, pyrophosphate, osteoprotegerin, receptor activator of nuclear factor-kappa B ligand (RANKL), fibroblast growth factor-23 (FGF-23), Klotho, osteopontin, osteocalcin, Matrix Gla protein (MGP) and its inactive forms and vitamin K. Studies solely performed in patients with kidney insufficiency or diabetes mellitus were excluded. Results: After screening of 8985 articles, a total of 129 articles were included in this systematic review. For all biomarkers included in this review, the results were variable and more than half of the studies for each specific biomarker had a non-significant result. Also, the overall quality of the included studies was low, partly as a result of the mostly cross-sectional study designs. The largest body of evidence is available for phosphate, osteopontin and FGF-23, as a little over half of the studies showed a significant, positive association. Firm statements for these biomarkers cannot be drawn, as the number of studies was limited and hampered by residual confounding or had non-significant results. The associations of the other mediators of ectopic mineralization with arterial calcifications were not clear. Conclusion: Associations between biomarkers of ectopic mineralization and arterial calcification are variable in the published literature. Future longitudinal studies differentiating medial and intimal calcification could add to the knowledge of biomarkers and mechanisms of arterial calcifications.http://www.sciencedirect.com/science/article/pii/S2352187222004338Arterial calcificationBiomarkersReview |
| spellingShingle | Nienke M.S. Golüke Marit A. Schoffelmeer Annemarieke De Jonghe Mariëlle H. Emmelot-Vonk Pim A. De Jong Huiberdina L. Koek Serum biomarkers for arterial calcification in humans: A systematic review Bone Reports Arterial calcification Biomarkers Review |
| title | Serum biomarkers for arterial calcification in humans: A systematic review |
| title_full | Serum biomarkers for arterial calcification in humans: A systematic review |
| title_fullStr | Serum biomarkers for arterial calcification in humans: A systematic review |
| title_full_unstemmed | Serum biomarkers for arterial calcification in humans: A systematic review |
| title_short | Serum biomarkers for arterial calcification in humans: A systematic review |
| title_sort | serum biomarkers for arterial calcification in humans a systematic review |
| topic | Arterial calcification Biomarkers Review |
| url | http://www.sciencedirect.com/science/article/pii/S2352187222004338 |
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