The role of inflammation in age-related macular degeneration
Age-related macular degeneration (AMD) is a complex, chronic, and progressive disease which affects the macular area, being one of the leading causes of irreversible vision loss worldwide. Specific alterations of retinal structure occur at the macular level, which regarding its severity can range fr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ion Motofei, Carol Davila University
2023-10-01
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| Series: | Journal of Mind and Medical Sciences |
| Subjects: | |
| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1421&context=jmms |
| _version_ | 1827692946765381632 |
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| author | Diana Florina Tricorache Ana Maria Dascalu Crenguta Serboiu Anca Bobirca Dragos Cretoiu Dan Bratu Corneliu Tudor Laura Carina Tribus |
| author_facet | Diana Florina Tricorache Ana Maria Dascalu Crenguta Serboiu Anca Bobirca Dragos Cretoiu Dan Bratu Corneliu Tudor Laura Carina Tribus |
| author_sort | Diana Florina Tricorache |
| collection | DOAJ |
| description | Age-related macular degeneration (AMD) is a complex, chronic, and progressive disease which affects the macular area, being one of the leading causes of irreversible vision loss worldwide. Specific alterations of retinal structure occur at the macular level, which regarding its severity can range from the presence of drusen to the development of geographic atrophy or choroidal neovascularization. AMD has long been considered a degenerative disease, but new studies highlight the role of inflammation present both in the atrophic form and in the exudative form. The present review is based on comprehensive research on PubMed and Web of Science databases, and it aims to describe the inflammatory pathways involved in AMD onset and progression. Understanding the molecules involved in AMD pathogenesis, and their mechanism of action, is crucial because they can be both biomarkers with a predictive role in disease management, as well as potential therapeutic targets. |
| first_indexed | 2024-03-10T11:33:58Z |
| format | Article |
| id | doaj.art-b9b5cd42ce0e4e4799b07a60b70cf335 |
| institution | Directory Open Access Journal |
| issn | 2392-7674 |
| language | English |
| last_indexed | 2024-03-10T11:33:58Z |
| publishDate | 2023-10-01 |
| publisher | Ion Motofei, Carol Davila University |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj.art-b9b5cd42ce0e4e4799b07a60b70cf3352023-11-21T19:03:06ZengIon Motofei, Carol Davila UniversityJournal of Mind and Medical Sciences2392-76742023-10-0110225425910.22543/2392-7674.1421The role of inflammation in age-related macular degenerationDiana Florina Tricorache0Ana Maria Dascalu1Crenguta Serboiu2Anca Bobirca3Dragos Cretoiu4Dan Bratu5Corneliu Tudor6Laura Carina Tribus7Carol Davila University of Medicine and Pharmacy, Doctoral School, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Doctoral School, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Faculty of General Medicine, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Faculty of General Medicine, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Faculty of General Medicine, Bucharest, RomaniaLucian Blaga University of Sibiu, Faculty of Medicine, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Faculty of General Medicine, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Faculty of Dental Medicine, Bucharest, RomaniaAge-related macular degeneration (AMD) is a complex, chronic, and progressive disease which affects the macular area, being one of the leading causes of irreversible vision loss worldwide. Specific alterations of retinal structure occur at the macular level, which regarding its severity can range from the presence of drusen to the development of geographic atrophy or choroidal neovascularization. AMD has long been considered a degenerative disease, but new studies highlight the role of inflammation present both in the atrophic form and in the exudative form. The present review is based on comprehensive research on PubMed and Web of Science databases, and it aims to describe the inflammatory pathways involved in AMD onset and progression. Understanding the molecules involved in AMD pathogenesis, and their mechanism of action, is crucial because they can be both biomarkers with a predictive role in disease management, as well as potential therapeutic targets.https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1421&context=jmmsinflammationage-relatedmacular degenerationretinal pigment epithelium |
| spellingShingle | Diana Florina Tricorache Ana Maria Dascalu Crenguta Serboiu Anca Bobirca Dragos Cretoiu Dan Bratu Corneliu Tudor Laura Carina Tribus The role of inflammation in age-related macular degeneration Journal of Mind and Medical Sciences inflammation age-related macular degeneration retinal pigment epithelium |
| title | The role of inflammation in age-related macular degeneration |
| title_full | The role of inflammation in age-related macular degeneration |
| title_fullStr | The role of inflammation in age-related macular degeneration |
| title_full_unstemmed | The role of inflammation in age-related macular degeneration |
| title_short | The role of inflammation in age-related macular degeneration |
| title_sort | role of inflammation in age related macular degeneration |
| topic | inflammation age-related macular degeneration retinal pigment epithelium |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1421&context=jmms |
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