A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in developed countries. CVD encompasses many diseased states, including hypertension, coronary artery disease and atherosclerosis. Studies in animal models and human studies have elucidated the contribution of man...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/10/3666 |
| _version_ | 1797567246745206784 |
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| author | Priscilla R. Prestes Michelle C. Maier Bradley A. Woods Fadi J. Charchar |
| author_facet | Priscilla R. Prestes Michelle C. Maier Bradley A. Woods Fadi J. Charchar |
| author_sort | Priscilla R. Prestes |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in developed countries. CVD encompasses many diseased states, including hypertension, coronary artery disease and atherosclerosis. Studies in animal models and human studies have elucidated the contribution of many genetic factors, including non-coding RNAs. Non-coding RNAs are RNAs not translated into protein, involved in gene expression regulation post-transcriptionally and implicated in CVD. Of these, circular RNAs (circRNAs) and microRNAs are relevant. CircRNAs are created by the back-splicing of pre-messenger RNA and have been underexplored as contributors to CVD. These circRNAs may also act as biomarkers of human disease, as they can be extracted from whole blood, plasma, saliva and seminal fluid. CircRNAs have recently been implicated in various disease processes, including hypertension and other cardiovascular disease. This review article will explore the promising and emerging roles of circRNAs as potential biomarkers and therapeutic targets in CVD, in particular hypertension. |
| first_indexed | 2024-03-10T19:40:01Z |
| format | Article |
| id | doaj.art-b9b6fec464c848398dac8650db1f00aa |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:40:01Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b9b6fec464c848398dac8650db1f00aa2023-11-20T01:24:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012110366610.3390/ijms21103666A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular DiseasePriscilla R. Prestes0Michelle C. Maier1Bradley A. Woods2Fadi J. Charchar3School of Health and Life Sciences, Federation University Australia, Ballarat, VIC 3350, AustraliaSchool of Health and Life Sciences, Federation University Australia, Ballarat, VIC 3350, AustraliaSchool of Health and Life Sciences, Federation University Australia, Ballarat, VIC 3350, AustraliaSchool of Health and Life Sciences, Federation University Australia, Ballarat, VIC 3350, AustraliaCardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in developed countries. CVD encompasses many diseased states, including hypertension, coronary artery disease and atherosclerosis. Studies in animal models and human studies have elucidated the contribution of many genetic factors, including non-coding RNAs. Non-coding RNAs are RNAs not translated into protein, involved in gene expression regulation post-transcriptionally and implicated in CVD. Of these, circular RNAs (circRNAs) and microRNAs are relevant. CircRNAs are created by the back-splicing of pre-messenger RNA and have been underexplored as contributors to CVD. These circRNAs may also act as biomarkers of human disease, as they can be extracted from whole blood, plasma, saliva and seminal fluid. CircRNAs have recently been implicated in various disease processes, including hypertension and other cardiovascular disease. This review article will explore the promising and emerging roles of circRNAs as potential biomarkers and therapeutic targets in CVD, in particular hypertension.https://www.mdpi.com/1422-0067/21/10/3666long non-coding RNAcircular RNAmicroRNAhypertensioncoronary artery diseaseatherosclerosis |
| spellingShingle | Priscilla R. Prestes Michelle C. Maier Bradley A. Woods Fadi J. Charchar A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease International Journal of Molecular Sciences long non-coding RNA circular RNA microRNA hypertension coronary artery disease atherosclerosis |
| title | A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease |
| title_full | A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease |
| title_fullStr | A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease |
| title_full_unstemmed | A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease |
| title_short | A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease |
| title_sort | guide to the short long and circular rnas in hypertension and cardiovascular disease |
| topic | long non-coding RNA circular RNA microRNA hypertension coronary artery disease atherosclerosis |
| url | https://www.mdpi.com/1422-0067/21/10/3666 |
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