The roles of ribosomal proteins in nasopharyngeal cancer: culprits, sentinels or both
Abstract Ribosomal protein genes encode products that are essential for cellular protein biosynthesis and are major components of ribosomes. Canonically, they are involved in the complex system of ribosome biogenesis pivotal to the catalysis of protein translation. Amid this tightly organised proces...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-021-00311-x |
| _version_ | 1831549220955357184 |
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| author | Edmund Ui-Hang Sim Choon-Weng Lee Kumaran Narayanan |
| author_facet | Edmund Ui-Hang Sim Choon-Weng Lee Kumaran Narayanan |
| author_sort | Edmund Ui-Hang Sim |
| collection | DOAJ |
| description | Abstract Ribosomal protein genes encode products that are essential for cellular protein biosynthesis and are major components of ribosomes. Canonically, they are involved in the complex system of ribosome biogenesis pivotal to the catalysis of protein translation. Amid this tightly organised process, some ribosomal proteins have unique spatial and temporal physiological activity giving rise to their extra-ribosomal functions. Many of these extra-ribosomal roles pertain to cellular growth and differentiation, thus implicating the involvement of some ribosomal proteins in organogenesis. Consequently, dysregulated functions of these ribosomal proteins could be linked to oncogenesis or neoplastic transformation of human cells. Their suspected roles in carcinogenesis have been reported but not specifically explained for malignancy of the nasopharynx. This is despite the fact that literature since one and half decade ago have documented the association of ribosomal proteins to nasopharyngeal cancer. In this review, we explain the association and contribution of dysregulated expression among a subset of ribosomal proteins to nasopharyngeal oncogenesis. The relationship of these ribosomal proteins with the cancer are explained. We provide information to indicate that the dysfunctional extra-ribosomal activities of specific ribosomal proteins are tightly involved with the molecular pathogenesis of nasopharyngeal cancer albeit mechanisms yet to be precisely defined. The complete knowledge of this will impact future applications in the effective management of nasopharyngeal cancer. |
| first_indexed | 2024-12-17T02:34:06Z |
| format | Article |
| id | doaj.art-b9b7d79106564e2798f09c05ab59a08c |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-12-17T02:34:06Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-b9b7d79106564e2798f09c05ab59a08c2022-12-21T22:06:54ZengBMCBiomarker Research2050-77712021-06-019111010.1186/s40364-021-00311-xThe roles of ribosomal proteins in nasopharyngeal cancer: culprits, sentinels or bothEdmund Ui-Hang Sim0Choon-Weng Lee1Kumaran Narayanan2Faculty of Resource Science and Technology, Universiti Malaysia SarawakInstitute of Biological Sciences, University of MalayaSchool of Science, Monash UniversityAbstract Ribosomal protein genes encode products that are essential for cellular protein biosynthesis and are major components of ribosomes. Canonically, they are involved in the complex system of ribosome biogenesis pivotal to the catalysis of protein translation. Amid this tightly organised process, some ribosomal proteins have unique spatial and temporal physiological activity giving rise to their extra-ribosomal functions. Many of these extra-ribosomal roles pertain to cellular growth and differentiation, thus implicating the involvement of some ribosomal proteins in organogenesis. Consequently, dysregulated functions of these ribosomal proteins could be linked to oncogenesis or neoplastic transformation of human cells. Their suspected roles in carcinogenesis have been reported but not specifically explained for malignancy of the nasopharynx. This is despite the fact that literature since one and half decade ago have documented the association of ribosomal proteins to nasopharyngeal cancer. In this review, we explain the association and contribution of dysregulated expression among a subset of ribosomal proteins to nasopharyngeal oncogenesis. The relationship of these ribosomal proteins with the cancer are explained. We provide information to indicate that the dysfunctional extra-ribosomal activities of specific ribosomal proteins are tightly involved with the molecular pathogenesis of nasopharyngeal cancer albeit mechanisms yet to be precisely defined. The complete knowledge of this will impact future applications in the effective management of nasopharyngeal cancer.https://doi.org/10.1186/s40364-021-00311-xRibosomal proteinsNasopharyngeal carcinomaCarcinogenesisCancer geneticsMedical genetics |
| spellingShingle | Edmund Ui-Hang Sim Choon-Weng Lee Kumaran Narayanan The roles of ribosomal proteins in nasopharyngeal cancer: culprits, sentinels or both Biomarker Research Ribosomal proteins Nasopharyngeal carcinoma Carcinogenesis Cancer genetics Medical genetics |
| title | The roles of ribosomal proteins in nasopharyngeal cancer: culprits, sentinels or both |
| title_full | The roles of ribosomal proteins in nasopharyngeal cancer: culprits, sentinels or both |
| title_fullStr | The roles of ribosomal proteins in nasopharyngeal cancer: culprits, sentinels or both |
| title_full_unstemmed | The roles of ribosomal proteins in nasopharyngeal cancer: culprits, sentinels or both |
| title_short | The roles of ribosomal proteins in nasopharyngeal cancer: culprits, sentinels or both |
| title_sort | roles of ribosomal proteins in nasopharyngeal cancer culprits sentinels or both |
| topic | Ribosomal proteins Nasopharyngeal carcinoma Carcinogenesis Cancer genetics Medical genetics |
| url | https://doi.org/10.1186/s40364-021-00311-x |
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