Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid
Emerging evidence indicates that probiotics have been proved to influence liver injury and regeneration. In the present study, the effects of Lactiplantibacillus plantarum AR113 on the liver regeneration were investigated in 70% partial hepatectomy (PHx) rats. Sprague-Dawley (SD) rats were gavaged w...
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| Format: | Article |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.800470/full |
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| author | Chunliang Xie Zhoumei Zhang Manyi Yang Cha Cao Yingjun Zhou Zuohua Zhu Wenbing Gong Chao Xu Li Yan Zhenxiu Hu Lianzhong Ai Yuande Peng |
| author_facet | Chunliang Xie Zhoumei Zhang Manyi Yang Cha Cao Yingjun Zhou Zuohua Zhu Wenbing Gong Chao Xu Li Yan Zhenxiu Hu Lianzhong Ai Yuande Peng |
| author_sort | Chunliang Xie |
| collection | DOAJ |
| description | Emerging evidence indicates that probiotics have been proved to influence liver injury and regeneration. In the present study, the effects of Lactiplantibacillus plantarum AR113 on the liver regeneration were investigated in 70% partial hepatectomy (PHx) rats. Sprague-Dawley (SD) rats were gavaged with L. plantarum AR113 suspensions (1 × 1010 CFU/mL) both before and after partial hepatectomy. The results showed that L. plantarum AR113 administration 2 weeks before partial hepatectomy can accelerate liver regeneration by increased hepatocyte proliferation and tumor necrosis factor-α (TNF-α), hepatocyte growth factor (HGF), and transforming growth factor-β (TGF-β) expression. Probiotic administration enriched Lactobacillus and Bacteroides and depleted Flavonifractor and Acetatifactor in the gut microbiome. Meanwhile, L. plantarum AR113 showed decline of phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidyl serine (PS), and lysophosphatidyl choline (LysoPC) levels in the serum of the rats after the L. plantarum AR113 administration. Moreover, L. plantarum AR113 treated rats exhibited higher concentrations of L-leucine, L-isoleucine, mevalonic acid, and lower 7-oxo-8-amino-nonanoic acid in plasma than that in PHx. Spearman correlation analysis revealed a significant correlation between changes in gut microbiota composition and glycerophospholipid. These results indicate that L. plantarum AR113 is promising for accelerating liver regeneration and provide new insights regarding the correlations among the microbiome, the metabolome, and liver regeneration. |
| first_indexed | 2024-12-20T10:16:12Z |
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| id | doaj.art-b9b8514e18c849f0add753314230d1a2 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-20T10:16:12Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Microbiology |
| spelling | doaj.art-b9b8514e18c849f0add753314230d1a22022-12-21T19:44:03ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-01-011210.3389/fmicb.2021.800470800470Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma GlycerophospholipidChunliang Xie0Zhoumei Zhang1Manyi Yang2Cha Cao3Yingjun Zhou4Zuohua Zhu5Wenbing Gong6Chao Xu7Li Yan8Zhenxiu Hu9Lianzhong Ai10Yuande Peng11Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, ChinaInstitute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, NHC Key Laboratory of Nanobiological Technology, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, ChinaInstitute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, ChinaInstitute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, ChinaInstitute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, ChinaInstitute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, ChinaInstitute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, ChinaInstitute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, ChinaShanghai Engineering Research Center of Food Microbiology, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaInstitute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, ChinaEmerging evidence indicates that probiotics have been proved to influence liver injury and regeneration. In the present study, the effects of Lactiplantibacillus plantarum AR113 on the liver regeneration were investigated in 70% partial hepatectomy (PHx) rats. Sprague-Dawley (SD) rats were gavaged with L. plantarum AR113 suspensions (1 × 1010 CFU/mL) both before and after partial hepatectomy. The results showed that L. plantarum AR113 administration 2 weeks before partial hepatectomy can accelerate liver regeneration by increased hepatocyte proliferation and tumor necrosis factor-α (TNF-α), hepatocyte growth factor (HGF), and transforming growth factor-β (TGF-β) expression. Probiotic administration enriched Lactobacillus and Bacteroides and depleted Flavonifractor and Acetatifactor in the gut microbiome. Meanwhile, L. plantarum AR113 showed decline of phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidyl serine (PS), and lysophosphatidyl choline (LysoPC) levels in the serum of the rats after the L. plantarum AR113 administration. Moreover, L. plantarum AR113 treated rats exhibited higher concentrations of L-leucine, L-isoleucine, mevalonic acid, and lower 7-oxo-8-amino-nonanoic acid in plasma than that in PHx. Spearman correlation analysis revealed a significant correlation between changes in gut microbiota composition and glycerophospholipid. These results indicate that L. plantarum AR113 is promising for accelerating liver regeneration and provide new insights regarding the correlations among the microbiome, the metabolome, and liver regeneration.https://www.frontiersin.org/articles/10.3389/fmicb.2021.800470/fullLactiplantibacillus plantarumpartial hepatectomyliver regenerationgut microbiotaplasma metabolitesglycerophospholipid |
| spellingShingle | Chunliang Xie Zhoumei Zhang Manyi Yang Cha Cao Yingjun Zhou Zuohua Zhu Wenbing Gong Chao Xu Li Yan Zhenxiu Hu Lianzhong Ai Yuande Peng Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid Frontiers in Microbiology Lactiplantibacillus plantarum partial hepatectomy liver regeneration gut microbiota plasma metabolites glycerophospholipid |
| title | Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid |
| title_full | Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid |
| title_fullStr | Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid |
| title_full_unstemmed | Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid |
| title_short | Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid |
| title_sort | lactiplantibacillus plantarum ar113 exhibit accelerated liver regeneration by regulating gut microbiota and plasma glycerophospholipid |
| topic | Lactiplantibacillus plantarum partial hepatectomy liver regeneration gut microbiota plasma metabolites glycerophospholipid |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.800470/full |
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