Metabolic aspects of bacterial persisters
Persister cells form a multi-drug tolerant subpopulation within an isogenic culture of bacteria that are genetically susceptible to antibiotics. Studies with different Gram negative and Gram positive bacteria have identified a large number of genes associated with the persister state. In contrast, t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00148/full |
| _version_ | 1818344865794097152 |
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| author | Marcel ePrax Ralph eBertram |
| author_facet | Marcel ePrax Ralph eBertram |
| author_sort | Marcel ePrax |
| collection | DOAJ |
| description | Persister cells form a multi-drug tolerant subpopulation within an isogenic culture of bacteria that are genetically susceptible to antibiotics. Studies with different Gram negative and Gram positive bacteria have identified a large number of genes associated with the persister state. In contrast, the revelation of persister metabolism has only been addressed recently. We here summarize metabolic aspects of persisters, which includes an overview about the bifunctional role of selected carbohydrates as both triggers for the exit from the drug tolerant state and metabolites which persisters feed on. Also alarmones as indicators for starvation have been shown to influence persister levels via different signaling cascades involving the activation of toxin-antitoxin systems and other regulatory factors. Finally, recent data obtained by 13C-isotopologue profiling demonstrated an active amino acid anabolism in Staphylococcus aureus cultures challenged with high drug concentrations. Understanding the metabolism of persister cells poses challenges but also paves the way for the development of anti-persister compounds. |
| first_indexed | 2024-12-13T16:53:16Z |
| format | Article |
| id | doaj.art-b9b89d66aade44ba91beebc2f61e4dc1 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-13T16:53:16Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-b9b89d66aade44ba91beebc2f61e4dc12022-12-21T23:37:58ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882014-10-01410.3389/fcimb.2014.00148109328Metabolic aspects of bacterial persistersMarcel ePrax0Ralph eBertram1Universität TübingenUniversität TübingenPersister cells form a multi-drug tolerant subpopulation within an isogenic culture of bacteria that are genetically susceptible to antibiotics. Studies with different Gram negative and Gram positive bacteria have identified a large number of genes associated with the persister state. In contrast, the revelation of persister metabolism has only been addressed recently. We here summarize metabolic aspects of persisters, which includes an overview about the bifunctional role of selected carbohydrates as both triggers for the exit from the drug tolerant state and metabolites which persisters feed on. Also alarmones as indicators for starvation have been shown to influence persister levels via different signaling cascades involving the activation of toxin-antitoxin systems and other regulatory factors. Finally, recent data obtained by 13C-isotopologue profiling demonstrated an active amino acid anabolism in Staphylococcus aureus cultures challenged with high drug concentrations. Understanding the metabolism of persister cells poses challenges but also paves the way for the development of anti-persister compounds.http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00148/fullMetabolismStaphylococcus aureusBiofilmPersisterstoxin-antitoxin systemppGpp |
| spellingShingle | Marcel ePrax Ralph eBertram Metabolic aspects of bacterial persisters Frontiers in Cellular and Infection Microbiology Metabolism Staphylococcus aureus Biofilm Persisters toxin-antitoxin system ppGpp |
| title | Metabolic aspects of bacterial persisters |
| title_full | Metabolic aspects of bacterial persisters |
| title_fullStr | Metabolic aspects of bacterial persisters |
| title_full_unstemmed | Metabolic aspects of bacterial persisters |
| title_short | Metabolic aspects of bacterial persisters |
| title_sort | metabolic aspects of bacterial persisters |
| topic | Metabolism Staphylococcus aureus Biofilm Persisters toxin-antitoxin system ppGpp |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00148/full |
| work_keys_str_mv | AT marceleprax metabolicaspectsofbacterialpersisters AT ralphebertram metabolicaspectsofbacterialpersisters |