NLRP3 exacerbates EAE severity through ROS-dependent NET formation in the mouse brain

NLRP3 exacerbates EAE severity through ROS-dependent NET formation in the mouse brain

Abstract Background Neutrophil extracellular trap (NET) has been implicated in the pathology of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). However, the specific contributions of NLRP3, a NET-associated molecule, to EAE pathogenesis and its regulatory role in NET for...

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Bibliographic Details
Main Authors: Da Jeong Byun, Jaeho Lee, Kyungryung Ko, Young-Min Hyun
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cell Communication and Signaling
Subjects:
EAE
Neutrophil
NET
Inflammation
NLRP3 inflammasome
Online Access:https://doi.org/10.1186/s12964-023-01447-z

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