Prognostic and Predictive Significance of PD-L1 Expression in Non-Small Cell Lung Cancer Patients: A Single-Center Experience
Objective: To investigate the prognostic and predictive value of PD-L1 expression in operated non-small cell lung cancer (NSCLC) patients and to analyze its relationship with clinicopathological factors. Material and Method: A total of 90 patients with operable NSCLC were included in this retrospec...
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Format: | Article |
Language: | English |
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Federation of Turkish Pathology Societies
2021-09-01
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Series: | Türk Patoloji Dergisi |
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http://www.turkjpath.org/pdf.php3?id=1982
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author | Hacı ARAK Aydın AYTEKIN Ozlem CANOZ Metin OZKAN |
author_facet | Hacı ARAK Aydın AYTEKIN Ozlem CANOZ Metin OZKAN |
author_sort | Hacı ARAK |
collection | DOAJ |
description | Objective: To investigate the prognostic and predictive value of PD-L1 expression in operated non-small cell lung cancer (NSCLC) patients and to analyze its relationship with clinicopathological factors.
Material and Method: A total of 90 patients with operable NSCLC were included in this retrospective single center study. Tumor blocks of patients were stained immunohistochemically with PD-L1 polyclonal antibody. When evaluated immunohistochemically and statistically, patients with tumor staining percentage of ≥5%, those with +2 and +3 membranous staining intensity, and those with ≥50% H-Score were considered positive. The relationship between PD-L1 expression status and clinicopathological features in addition to the prognostic effect of PD-L1 on survival were statistically analyzed.
Results: The frequency of PD-L1 expression was 37%, 15% and 5% according to the staining percentage, staining intensity, and the H-Score, respectively. There was no significant relationship between PD-L1 expression and age, gender, smoking, tumor stage and histological subtype (p> 0.05). However, PD-L1 expression was relatively higher in patients <65 years of age, men, smokers, patients with advanced tumor stage, and squamous cell subtype. based on the analysis h-score, no significant difference was noted regarding disease-free survival time between pd-l1 positive negative (median 20 [95% ci 1.2-38.7] months vs. median 27 17.5-36] months, p =0.208). however, overall significantly shorter in compared to 24 9.9-38] 48 33.6-62.3],> Conclusion: In patients with high PD-L1 expression, the biological behavior of the cancer was more aggressive, and the life expectancy was shorter. PD-L1 expression seems to be a poor prognostic marker in NSCLC patients. |
first_indexed | 2024-04-10T13:40:28Z |
format | Article |
id | doaj.art-b9bade25e7c94c64a222ef26f0a9f193 |
institution | Directory Open Access Journal |
issn | 1018-5615 1309-5730 |
language | English |
last_indexed | 2024-04-10T13:40:28Z |
publishDate | 2021-09-01 |
publisher | Federation of Turkish Pathology Societies |
record_format | Article |
series | Türk Patoloji Dergisi |
spelling | doaj.art-b9bade25e7c94c64a222ef26f0a9f1932023-02-15T16:11:12ZengFederation of Turkish Pathology SocietiesTürk Patoloji Dergisi1018-56151309-57302021-09-0137323924810.5146/tjpath.2021.01545Prognostic and Predictive Significance of PD-L1 Expression in Non-Small Cell Lung Cancer Patients: A Single-Center ExperienceHacı ARAKAydın AYTEKINOzlem CANOZMetin OZKANObjective: To investigate the prognostic and predictive value of PD-L1 expression in operated non-small cell lung cancer (NSCLC) patients and to analyze its relationship with clinicopathological factors. Material and Method: A total of 90 patients with operable NSCLC were included in this retrospective single center study. Tumor blocks of patients were stained immunohistochemically with PD-L1 polyclonal antibody. When evaluated immunohistochemically and statistically, patients with tumor staining percentage of ≥5%, those with +2 and +3 membranous staining intensity, and those with ≥50% H-Score were considered positive. The relationship between PD-L1 expression status and clinicopathological features in addition to the prognostic effect of PD-L1 on survival were statistically analyzed. Results: The frequency of PD-L1 expression was 37%, 15% and 5% according to the staining percentage, staining intensity, and the H-Score, respectively. There was no significant relationship between PD-L1 expression and age, gender, smoking, tumor stage and histological subtype (p> 0.05). However, PD-L1 expression was relatively higher in patients <65 years of age, men, smokers, patients with advanced tumor stage, and squamous cell subtype. based on the analysis h-score, no significant difference was noted regarding disease-free survival time between pd-l1 positive negative (median 20 [95% ci 1.2-38.7] months vs. median 27 17.5-36] months, p =0.208). however, overall significantly shorter in compared to 24 9.9-38] 48 33.6-62.3],> Conclusion: In patients with high PD-L1 expression, the biological behavior of the cancer was more aggressive, and the life expectancy was shorter. PD-L1 expression seems to be a poor prognostic marker in NSCLC patients. http://www.turkjpath.org/pdf.php3?id=1982 lungnon-small cell cancerpd-l1h-score |
spellingShingle | Hacı ARAK Aydın AYTEKIN Ozlem CANOZ Metin OZKAN Prognostic and Predictive Significance of PD-L1 Expression in Non-Small Cell Lung Cancer Patients: A Single-Center Experience Türk Patoloji Dergisi lung non-small cell cancer pd-l1 h-score |
title | Prognostic and Predictive Significance of PD-L1 Expression in Non-Small Cell Lung Cancer Patients: A Single-Center Experience |
title_full | Prognostic and Predictive Significance of PD-L1 Expression in Non-Small Cell Lung Cancer Patients: A Single-Center Experience |
title_fullStr | Prognostic and Predictive Significance of PD-L1 Expression in Non-Small Cell Lung Cancer Patients: A Single-Center Experience |
title_full_unstemmed | Prognostic and Predictive Significance of PD-L1 Expression in Non-Small Cell Lung Cancer Patients: A Single-Center Experience |
title_short | Prognostic and Predictive Significance of PD-L1 Expression in Non-Small Cell Lung Cancer Patients: A Single-Center Experience |
title_sort | prognostic and predictive significance of pd l1 expression in non small cell lung cancer patients a single center experience |
topic | lung non-small cell cancer pd-l1 h-score |
url |
http://www.turkjpath.org/pdf.php3?id=1982
|
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