The risk of pancreatic adenocarcinoma following SARS-CoV family infection
Abstract COVID 19 disease has become a global catastrophe over the past year that has claimed the lives of over two million people around the world. Despite the introduction of vaccines against the disease, there is still a long way to completely eradicate it. There are concerns about the complicati...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-92068-4 |
| _version_ | 1818839226070859776 |
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| author | Amin Ebrahimi Sadrabadi Ahmad Bereimipour Arsalan Jalili Mazaher Gholipurmalekabadi Behrouz Farhadihosseinabadi Alexander M. Seifalian |
| author_facet | Amin Ebrahimi Sadrabadi Ahmad Bereimipour Arsalan Jalili Mazaher Gholipurmalekabadi Behrouz Farhadihosseinabadi Alexander M. Seifalian |
| author_sort | Amin Ebrahimi Sadrabadi |
| collection | DOAJ |
| description | Abstract COVID 19 disease has become a global catastrophe over the past year that has claimed the lives of over two million people around the world. Despite the introduction of vaccines against the disease, there is still a long way to completely eradicate it. There are concerns about the complications following infection with SARS-CoV-2. This research aimed to evaluate the possible correlation between infection with SARS-CoV viruses and cancer in an in-silico study model. To do this, the relevent dataset was selected from GEO database. Identification of differentially expressed genes among defined groups including SARS-CoV, SARS-dORF6, SARS-BatSRBD, and H1N1 were screened where the |Log FC| ≥ 1and p < 0.05 were considered statistically significant. Later, the pathway enrichment analysis and gene ontology (GO) were used by Enrichr and Shiny GO databases. Evaluation with STRING online was applied to predict the functional interactions of proteins, followed by Cytoscape analysis to identify the master genes. Finally, analysis with GEPIA2 server was carried out to reveal the possible correlation between candidate genes and cancer development. The results showed that the main molecular function of up- and down-regulated genes was “double-stranded RNA binding” and actin-binding, respectively. STRING and Cytoscape analysis presented four genes, PTEN, CREB1, CASP3, and SMAD3 as the key genes involved in cancer development. According to TCGA database results, these four genes were up-regulated notably in pancreatic adenocarcinoma. Our findings suggest that pancreatic adenocarcinoma is the most probably malignancy happening after infection with SARS-CoV family. |
| first_indexed | 2024-12-19T03:50:55Z |
| format | Article |
| id | doaj.art-b9bc72f639824761b1d31205d295689d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T03:50:55Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b9bc72f639824761b1d31205d295689d2022-12-21T20:37:00ZengNature PortfolioScientific Reports2045-23222021-06-0111111310.1038/s41598-021-92068-4The risk of pancreatic adenocarcinoma following SARS-CoV family infectionAmin Ebrahimi Sadrabadi0Ahmad Bereimipour1Arsalan Jalili2Mazaher Gholipurmalekabadi3Behrouz Farhadihosseinabadi4Alexander M. Seifalian5Department of Stem Cells and Developmental Biology at Cell Science Research Centre, Royan InstituteDepartment of Stem Cells and Developmental Biology at Cell Science Research Centre, Royan InstituteDepartment of Stem Cells and Developmental Biology at Cell Science Research Centre, Royan InstituteCellular and Molecular Research Centre, Department of Tissue Engineering and Regenerative Medicine, Iran University of Medical SciencesHematopoetic Stem Cell Research Centre, Shahid Beheshti University of Medical SciencesNanotechnology and Regenerative Medicine Commercialization Centre (Ltd), London BioScience Innovation CentreAbstract COVID 19 disease has become a global catastrophe over the past year that has claimed the lives of over two million people around the world. Despite the introduction of vaccines against the disease, there is still a long way to completely eradicate it. There are concerns about the complications following infection with SARS-CoV-2. This research aimed to evaluate the possible correlation between infection with SARS-CoV viruses and cancer in an in-silico study model. To do this, the relevent dataset was selected from GEO database. Identification of differentially expressed genes among defined groups including SARS-CoV, SARS-dORF6, SARS-BatSRBD, and H1N1 were screened where the |Log FC| ≥ 1and p < 0.05 were considered statistically significant. Later, the pathway enrichment analysis and gene ontology (GO) were used by Enrichr and Shiny GO databases. Evaluation with STRING online was applied to predict the functional interactions of proteins, followed by Cytoscape analysis to identify the master genes. Finally, analysis with GEPIA2 server was carried out to reveal the possible correlation between candidate genes and cancer development. The results showed that the main molecular function of up- and down-regulated genes was “double-stranded RNA binding” and actin-binding, respectively. STRING and Cytoscape analysis presented four genes, PTEN, CREB1, CASP3, and SMAD3 as the key genes involved in cancer development. According to TCGA database results, these four genes were up-regulated notably in pancreatic adenocarcinoma. Our findings suggest that pancreatic adenocarcinoma is the most probably malignancy happening after infection with SARS-CoV family.https://doi.org/10.1038/s41598-021-92068-4 |
| spellingShingle | Amin Ebrahimi Sadrabadi Ahmad Bereimipour Arsalan Jalili Mazaher Gholipurmalekabadi Behrouz Farhadihosseinabadi Alexander M. Seifalian The risk of pancreatic adenocarcinoma following SARS-CoV family infection Scientific Reports |
| title | The risk of pancreatic adenocarcinoma following SARS-CoV family infection |
| title_full | The risk of pancreatic adenocarcinoma following SARS-CoV family infection |
| title_fullStr | The risk of pancreatic adenocarcinoma following SARS-CoV family infection |
| title_full_unstemmed | The risk of pancreatic adenocarcinoma following SARS-CoV family infection |
| title_short | The risk of pancreatic adenocarcinoma following SARS-CoV family infection |
| title_sort | risk of pancreatic adenocarcinoma following sars cov family infection |
| url | https://doi.org/10.1038/s41598-021-92068-4 |
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