To Study the Levels of C - Reactive Protein and Total Leucocyte Count in Patients Operated of Open and Laparoscopic Cholecystectomy
Background: The recovery from laparoscopic cholecystectomy (LC) is rapid and most of the patients are discharged on the 1st post-operative day. There is an increased concentration of certain serum proteins, known as acute-phase reactive proteins (APRP) during the post-operative period depends on...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4487/7094_E(C)_F(T)_PF1(PAK)_PFA(AK)_PF2(PN).pdf |
| Summary: | Background: The recovery from laparoscopic cholecystectomy
(LC) is rapid and most of the patients are discharged on the 1st
post-operative day. There is an increased concentration of certain
serum proteins, known as acute-phase reactive proteins (APRP)
during the post-operative period depends on the degree of tissue
damage and the inflammatory reaction. There is a direct positive
correlation between the concentrations of APRP, especially
C-reactive protein (CRP), and the severity of inflammation. This
study was done to study the levels of C - reactive protein and
Total Leucocyte Count in patients operated either by Open
Cholecystectomy (OC) and Laparoscopic Cholecystectomy
(LC).
Materials and Methods: This prospective study was conducted on
50 patients after approval from the Institutional Ethics Committee.
Twenty five patients underwent open cholecystectomy and the
other 25 had laparoscopic cholecystectomy. The pre and post
operative concentrations of serum C-reactive protein (CRP) and
total leukocyte count (TLC) were compared in both the groups.
Results: There were no differences in the preoperative serum
CRP and TLC concentrations – in both the groups. Serum CRP
rose significantly following OC compared to that of patients who
underwent LC (10.52 ± 1.96 mg% vs. 8.88 ± 1.23 mg %). There
were also significant differences in the post-operative TLC ( 9.49
± 1.05 m/mm3
for the OC group vs. 8.57 ± 1.31 m/mm3
for the LC
group), and the post-operative hospital stay (5.5 ±1.5 days vs.
1.9 ± 0.9 days). There was no correlation between serum CRP
concentrations and the other post-operative parameters.
Conclusion: The study provided the biochemical evidence
supporting the clinical observation that LC is far less traumatic
to the patient than OC. |
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| ISSN: | 2249-782X 0973-709X |