A unique case of chronic myeloid leukemia presenting as monocular vision loss with unilateral retinopathy
Purpose: To report a case of unilateral leukemic retinopathy secondary to chronic myeloid leukemia (CML). Observations: Patient presented to clinic with a visual acuity (VA) of 20/200 in the right eye (OD) after several months of progressive monocular vision loss and was found to have dense pre-reti...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-06-01
|
| Series: | American Journal of Ophthalmology Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S245199361830238X |
| _version_ | 1819032979299631104 |
|---|---|
| author | Mark P. Seraly Sumeet K. Gupta Inderjit Mehmi Lauren Veltri Ghassan R. Ghorayeb |
| author_facet | Mark P. Seraly Sumeet K. Gupta Inderjit Mehmi Lauren Veltri Ghassan R. Ghorayeb |
| author_sort | Mark P. Seraly |
| collection | DOAJ |
| description | Purpose: To report a case of unilateral leukemic retinopathy secondary to chronic myeloid leukemia (CML). Observations: Patient presented to clinic with a visual acuity (VA) of 20/200 in the right eye (OD) after several months of progressive monocular vision loss and was found to have dense pre-retinal hemorrhage. Patient underwent 23-gauge pars plana vitrectomy to clear the preretinal hemorrhage along with a complex macula-off retinal detachment repair to address retinal tear and multilayer retinal hemorrhage. The patient was subsequently diagnosed with CML as she was found to be positive for the fusion protein of break point cluster gene (BCR) with Abelson tyrosine kinase (ABL1), BCR-ABL1, upon systemic work-up. Imatinib therapy resulted in complete hematologic and cytogenetic resolution after one month, however, the patient's vision remained unchanged six months after surgery. Conclusion and importance: To the authors' knowledge, this is the first reported case of unilateral leukemic retinopathy secondary to low risk CML, as determined by the Sokal and Hasford prognostic scoring systems. CML should be included in the differential diagnosis of patients with progressive monocular vision loss with suspicious multi-layer retinal compromise. Keywords: BCR-ABL1, Chronic myeloid leukemia, Hasford, Imatinib, Monocular vision loss, Sokal, Unilateral retinopathy |
| first_indexed | 2024-12-21T07:10:33Z |
| format | Article |
| id | doaj.art-b9bd7857d34d4e3280bc50ef3c472637 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-21T07:10:33Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-b9bd7857d34d4e3280bc50ef3c4726372022-12-21T19:11:59ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362019-06-01146769A unique case of chronic myeloid leukemia presenting as monocular vision loss with unilateral retinopathyMark P. Seraly0Sumeet K. Gupta1Inderjit Mehmi2Lauren Veltri3Ghassan R. Ghorayeb4West Virginia University School of Medicine, 1 Medical Center Dr, Morgantown, WV, USA; Corresponding author. 13 Willow Lane, Morgantown, WV, 26505, USA.West Virginia University School of Medicine, 1 Medical Center Dr, Morgantown, WV, USAWest Virginia University School of Medicine, 1 Medical Center Dr, Morgantown, WV, USA; West Virginia University Cancer Institute, Section of Hematology/Oncology, 1 Medical Center Dr, Morgantown, WV, USAWest Virginia University School of Medicine, 1 Medical Center Dr, Morgantown, WV, USA; West Virginia University Cancer Institute, Section of Hematology/Oncology, 1 Medical Center Dr, Morgantown, WV, USAWest Virginia University School of Medicine, 1 Medical Center Dr, Morgantown, WV, USAPurpose: To report a case of unilateral leukemic retinopathy secondary to chronic myeloid leukemia (CML). Observations: Patient presented to clinic with a visual acuity (VA) of 20/200 in the right eye (OD) after several months of progressive monocular vision loss and was found to have dense pre-retinal hemorrhage. Patient underwent 23-gauge pars plana vitrectomy to clear the preretinal hemorrhage along with a complex macula-off retinal detachment repair to address retinal tear and multilayer retinal hemorrhage. The patient was subsequently diagnosed with CML as she was found to be positive for the fusion protein of break point cluster gene (BCR) with Abelson tyrosine kinase (ABL1), BCR-ABL1, upon systemic work-up. Imatinib therapy resulted in complete hematologic and cytogenetic resolution after one month, however, the patient's vision remained unchanged six months after surgery. Conclusion and importance: To the authors' knowledge, this is the first reported case of unilateral leukemic retinopathy secondary to low risk CML, as determined by the Sokal and Hasford prognostic scoring systems. CML should be included in the differential diagnosis of patients with progressive monocular vision loss with suspicious multi-layer retinal compromise. Keywords: BCR-ABL1, Chronic myeloid leukemia, Hasford, Imatinib, Monocular vision loss, Sokal, Unilateral retinopathyhttp://www.sciencedirect.com/science/article/pii/S245199361830238X |
| spellingShingle | Mark P. Seraly Sumeet K. Gupta Inderjit Mehmi Lauren Veltri Ghassan R. Ghorayeb A unique case of chronic myeloid leukemia presenting as monocular vision loss with unilateral retinopathy American Journal of Ophthalmology Case Reports |
| title | A unique case of chronic myeloid leukemia presenting as monocular vision loss with unilateral retinopathy |
| title_full | A unique case of chronic myeloid leukemia presenting as monocular vision loss with unilateral retinopathy |
| title_fullStr | A unique case of chronic myeloid leukemia presenting as monocular vision loss with unilateral retinopathy |
| title_full_unstemmed | A unique case of chronic myeloid leukemia presenting as monocular vision loss with unilateral retinopathy |
| title_short | A unique case of chronic myeloid leukemia presenting as monocular vision loss with unilateral retinopathy |
| title_sort | unique case of chronic myeloid leukemia presenting as monocular vision loss with unilateral retinopathy |
| url | http://www.sciencedirect.com/science/article/pii/S245199361830238X |
| work_keys_str_mv | AT markpseraly auniquecaseofchronicmyeloidleukemiapresentingasmonocularvisionlosswithunilateralretinopathy AT sumeetkgupta auniquecaseofchronicmyeloidleukemiapresentingasmonocularvisionlosswithunilateralretinopathy AT inderjitmehmi auniquecaseofchronicmyeloidleukemiapresentingasmonocularvisionlosswithunilateralretinopathy AT laurenveltri auniquecaseofchronicmyeloidleukemiapresentingasmonocularvisionlosswithunilateralretinopathy AT ghassanrghorayeb auniquecaseofchronicmyeloidleukemiapresentingasmonocularvisionlosswithunilateralretinopathy AT markpseraly uniquecaseofchronicmyeloidleukemiapresentingasmonocularvisionlosswithunilateralretinopathy AT sumeetkgupta uniquecaseofchronicmyeloidleukemiapresentingasmonocularvisionlosswithunilateralretinopathy AT inderjitmehmi uniquecaseofchronicmyeloidleukemiapresentingasmonocularvisionlosswithunilateralretinopathy AT laurenveltri uniquecaseofchronicmyeloidleukemiapresentingasmonocularvisionlosswithunilateralretinopathy AT ghassanrghorayeb uniquecaseofchronicmyeloidleukemiapresentingasmonocularvisionlosswithunilateralretinopathy |