Importance of the 2,6-Difluorobenzamide Motif for FtsZ Allosteric Inhibition: Insights from Conformational Analysis, Molecular Docking and Structural Modifications

Importance of the 2,6-Difluorobenzamide Motif for FtsZ Allosteric Inhibition: Insights from Conformational Analysis, Molecular Docking and Structural Modifications

A conformational analysis and molecular docking study comparing 2,6-difluoro-3-methoxybenzamide (DFMBA) with 3-methoxybenzamide (3-MBA) has been undertaken for investigating the known increase of FtsZ inhibition related anti <i>S. aureus</i> activity due to fluorination. For the isolated...

Full description

Bibliographic Details
Main Authors:	Thibaut Barbier, Oana Dumitrescu, Gérard Lina, Yves Queneau, Laurent Soulère
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Molecules
Subjects:	conformational analysis 2,6-difluorobenzamide FtsZ <i>S. aureus</i>
Online Access:	https://www.mdpi.com/1420-3049/28/5/2055

Similar Items

Computational docking of FtsZ: Survey of promising antibiotic compounds
by: Ileini N. Espino, et al.
Published: (2024-09-01)

Antimicrobial Action and Reversal of Resistance in MRSA by Difluorobenzamide Derivatives Targeted at FtsZ
by: Wern Chern Chai, et al.
Published: (2020-12-01)

Obtainment of <i>Threo</i> and <i>Erythro</i> Isomers of the 6-Fluoro-3-(2,3,6,7,8,9-hexahydronaphtho[2,3-<i>b</i>][1,4]dioxin-2-yl)-2,3-dihydrobenzo[<i>b</i>][1,4]dioxine-5-carboxamide
by: Valentina Straniero, et al.
Published: (2023-01-01)

Antistaphylococcal Activity of the FtsZ Inhibitor C109
by: Gabriele Trespidi, et al.
Published: (2021-07-01)

A Thiazole Orange Derivative Targeting the Bacterial Protein FtsZ Shows Potent Antibacterial Activity
by: Ning Sun, et al.
Published: (2017-05-01)

A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches
by: Philipp Radler, et al.
Published: (2024-03-01)

FtsZ-less prokaryotic cell division as well as FtsZ- and dynamin-less chloroplast and non-photosynthetic plastid division
by: Shin-Ya eMiyagishima
Published: (2014-09-01)

Bactericidal and Anti-Biofilm Activity of the FtsZ Inhibitor C109 against <i>Acinetobacter baumannii</i>
by: Viola Camilla Scoffone, et al.
Published: (2022-11-01)

Investigating the effect of bacteriophages on bacterial FtsZ localisation
by: Gurneet K. Dhanoa, et al.
Published: (2022-07-01)

Early origin and evolution of the FtsZ/tubulin protein family
by: Carlos Santana-Molina, et al.
Published: (2023-01-01)

The Search for Antibacterial Inhibitors Targeting Cell Division Protein FtsZ at Its Nucleotide and Allosteric Binding Sites
by: José M. Andreu, et al.
Published: (2022-07-01)

Genome-Editing of <i>FtsZ1</i> for Alteration of Starch Granule Size in Potato Tubers
by: Alexander C. Pfotenhauer, et al.
Published: (2023-05-01)

Searching for New Antibacterial Compounds Against <i>Staphylococcus aureus</i>: A Computational Study on the Binding Between FtsZ and FtsA
by: Alba V. Demesa-Castañeda, et al.
Published: (2024-11-01)

Synthesis and degradation of FtsZ quantitatively predict the first cell division in starved bacteria
by: Karthik Sekar, et al.
Published: (2018-11-01)

Differential GTP-dependent in-vitro polymerization of recombinant Physcomitrella FtsZ proteins
by: Stella W. L. Milferstaedt, et al.
Published: (2025-01-01)

Complete identity and expression of StfZ, the cis-antisense RNA to the mRNA of the cell division gene ftsZ, in Escherichia coli
by: Deepak Anand, et al.
Published: (2022-10-01)

Interaction of Temporin-L Analogues with the <i>E. coli</i> FtsZ Protein
by: Angela Di Somma, et al.
Published: (2021-06-01)

The Repurposing of FDA-Approved Drugs as FtsZ Inhibitors against <i>Mycobacterium tuberculosis</i>: An In Silico and In Vitro Study
by: Andrea Michel Tovar-Nieto, et al.
Published: (2024-07-01)

Homology modeling, virtual screening, molecular docking, and dynamics studies for discovering Staphylococcus epidermidis FtsZ inhibitors
by: Divya Vemula, et al.
Published: (2023-03-01)

Purification and characterization of FtsZ from the citrus canker pathogen Xanthomonas citri subsp. citri
by: Malgorzata M. Kopacz, et al.
Published: (2019-05-01)

Computational Design and Development of Benzodioxane-Benzamides as Potent Inhibitors of FtsZ by Exploring the Hydrophobic Subpocket
by: Valentina Straniero, et al.
Published: (2021-04-01)

The Antitumor Agent Ansamitocin P-3 Binds to Cell Division Protein FtsZ in <i>Actinosynnema pretiosum</i>
by: Xinran Wang, et al.
Published: (2020-04-01)

Indole-core-based novel antibacterial agent targeting FtsZ
by: Yuan W, et al.
Published: (2019-07-01)

Proposal of Potent Inhibitors for a Bacterial Cell Division Protein FtsZ: Molecular Simulations Based on Molecular Docking and ab Initio Molecular Orbital Calculations
by: Shohei Yamamoto, et al.
Published: (2020-11-01)

Antibacterial Activity of an FtsZ Inhibitor Celastrol and Its Synergistic Effect with Vancomycin against Enterococci In Vitro and In Vivo
by: Xi Lu, et al.
Published: (2023-02-01)

Role of the antiparallel double-stranded filament form of FtsA in activating the Escherichia coli divisome
by: Abbigale Perkins, et al.
Published: (2024-08-01)

Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division
by: Fenghui Guan, et al.
Published: (2018-06-01)

Bacteriophage P1 protein Icd inhibits bacterial division by targeting FtsZ
by: Kairui Zhao, et al.
Published: (2025-02-01)

Molecular Characterization of the <i>Burkholderia cenocepacia</i> <i>dcw</i> Operon and FtsZ Interactors as New Targets for Novel Antimicrobial Design
by: Gabriele Trespidi, et al.
Published: (2020-11-01)

Three-Dimensional Superresolution Imaging of the FtsZ Ring during Cell Division of the Cyanobacterium <italic toggle="yes">Prochlorococcus</italic>
by: Riyue Liu, et al.
Published: (2017-12-01)

The study of honokiol as a natural product-based antimicrobial agent and its potential interaction with FtsZ protein
by: Ning Sun, et al.
Published: (2024-07-01)

Effects of rhodomyrtone on Gram-positive bacterial tubulin homologue FtsZ
by: Dennapa Saeloh, et al.
Published: (2017-02-01)

FtsE, the Nucleotide Binding Domain of the ABC Transporter Homolog FtsEX, Regulates Septal PG Synthesis in E. coli
by: Sunanda Mallik, et al.
Published: (2023-06-01)

Discovery of 2′,6-Bis(4-hydroxybenzyl)-2-acetylcyclohexanone, a Novel FtsZ Inhibitor
by: Hsuan-Yu J. Lin, et al.
Published: (2022-10-01)

A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria
by: Félix Ramos-León, et al.
Published: (2021-03-01)

Cytological profile of antibacterial FtsZ inhibitors and synthetic peptide MciZ
by: Lidia Araujo-Bazan, et al.
Published: (2016-10-01)

Genome-Wide Analysis of Tubulin Gene Family in Cassava and Expression of Family Member <i>FtsZ2-1</i> during Various Stress
by: Shuangbao Li, et al.
Published: (2021-03-01)

The Min System Disassembles FtsZ Foci and Inhibits Polar Peptidoglycan Remodeling in <named-content content-type="genus-species">Bacillus subtilis</named-content>
by: Yuanchen Yu, et al.
Published: (2020-04-01)

FtsZ Interactions and Biomolecular Condensates as Potential Targets for New Antibiotics
by: Silvia Zorrilla, et al.
Published: (2021-03-01)

A FtsZ Inhibitor That Can Utilize Siderophore-Ferric Iron Uptake Transporter Systems for Activity against Gram-Negative Bacterial Pathogens
by: Eric J. Bryan, et al.
Published: (2024-02-01)