A comparison of the chest radiographic and computed tomographic features of subclinical pulmonary tuberculosis
Abstract Subclinical pulmonary tuberculosis (PTB) is a recently described intermediate state of great interest, but about which little is known. This study sought to describe and compare the frequency of key radiologic features of subclinical PTB on chest radiograph (CXR) versus computed tomographic...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-21016-7 |
| _version_ | 1817979622979010560 |
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| author | Angela Lau Christopher Lin James Barrie Christopher Winter Gavin Armstrong Mary Lou Egedahl Alexander Doroshenko Courtney Heffernan Leyla Asadi Dina Fisher Catherine Paulsen Jalal Moolji Yiming Huang Richard Long |
| author_facet | Angela Lau Christopher Lin James Barrie Christopher Winter Gavin Armstrong Mary Lou Egedahl Alexander Doroshenko Courtney Heffernan Leyla Asadi Dina Fisher Catherine Paulsen Jalal Moolji Yiming Huang Richard Long |
| author_sort | Angela Lau |
| collection | DOAJ |
| description | Abstract Subclinical pulmonary tuberculosis (PTB) is a recently described intermediate state of great interest, but about which little is known. This study sought to describe and compare the frequency of key radiologic features of subclinical PTB on chest radiograph (CXR) versus computed tomographic scan (CT), and to interpret the clinical and public health relevance of the differences. Diagnostic CXRs and CT scans of the thorax and neck in a 16-year cohort of subclinical PTB patients in Canada were re-acquired and read by two independent readers and arbitrated by a third reader. Logistic regression models were fit to determine how likely CXR features can be detected by CT scan versus CXR after adjustment for age and sex. Among 296 subclinical patients, CXRs were available in 286 (96.6%) and CT scans in 94 (32.9%). CXR features in patients with and without CT scans were comparable. Lung cavitation was 4.77 times (95% CI 1.95–11.66), endobronchial spread 19.36 times (95% CI 8.05–46.52), and moderate/far-advanced parenchymal disease 3.23 times (95% CI 1.66–6.30), more common on CT scan than CXR. We conclude that the extent to which CXRs under-detect key radiologic features in subclinical PTB is substantial. This may have public health and treatment implications. |
| first_indexed | 2024-04-13T22:44:53Z |
| format | Article |
| id | doaj.art-b9bef472d26740fd9d5fda2d229e0404 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T22:44:53Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b9bef472d26740fd9d5fda2d229e04042022-12-22T02:26:28ZengNature PortfolioScientific Reports2045-23222022-10-0112111110.1038/s41598-022-21016-7A comparison of the chest radiographic and computed tomographic features of subclinical pulmonary tuberculosisAngela Lau0Christopher Lin1James Barrie2Christopher Winter3Gavin Armstrong4Mary Lou Egedahl5Alexander Doroshenko6Courtney Heffernan7Leyla Asadi8Dina Fisher9Catherine Paulsen10Jalal Moolji11Yiming Huang12Richard Long13The Department of Medicine, Faculty of Medicine and Dentistry, University of AlbertaThe Department of Family Medicine, Faculty of Medicine and Dentistry, University of AlbertaThe Department of Radiology and Diagnostic Imaging, Faculty of Medicine and Dentistry, University of AlbertaThe Department of Radiology and Diagnostic Imaging, Faculty of Medicine and Dentistry, University of AlbertaThe Department of Radiology and Diagnostic Imaging, Faculty of Medicine and Dentistry, University of AlbertaThe Department of Medicine, Faculty of Medicine and Dentistry, University of AlbertaThe Department of Medicine, Faculty of Medicine and Dentistry, University of AlbertaThe Department of Medicine, Faculty of Medicine and Dentistry, University of AlbertaThe Department of Medicine, Faculty of Medicine and Dentistry, University of AlbertaCumming School of Medicine, University of CalgaryThe Department of Medicine, Faculty of Medicine and Dentistry, University of AlbertaThe Department of Medicine, Faculty of Medicine and Dentistry, University of AlbertaThe Department of Medicine, Faculty of Medicine and Dentistry, University of AlbertaThe Department of Medicine, Faculty of Medicine and Dentistry, University of AlbertaAbstract Subclinical pulmonary tuberculosis (PTB) is a recently described intermediate state of great interest, but about which little is known. This study sought to describe and compare the frequency of key radiologic features of subclinical PTB on chest radiograph (CXR) versus computed tomographic scan (CT), and to interpret the clinical and public health relevance of the differences. Diagnostic CXRs and CT scans of the thorax and neck in a 16-year cohort of subclinical PTB patients in Canada were re-acquired and read by two independent readers and arbitrated by a third reader. Logistic regression models were fit to determine how likely CXR features can be detected by CT scan versus CXR after adjustment for age and sex. Among 296 subclinical patients, CXRs were available in 286 (96.6%) and CT scans in 94 (32.9%). CXR features in patients with and without CT scans were comparable. Lung cavitation was 4.77 times (95% CI 1.95–11.66), endobronchial spread 19.36 times (95% CI 8.05–46.52), and moderate/far-advanced parenchymal disease 3.23 times (95% CI 1.66–6.30), more common on CT scan than CXR. We conclude that the extent to which CXRs under-detect key radiologic features in subclinical PTB is substantial. This may have public health and treatment implications.https://doi.org/10.1038/s41598-022-21016-7 |
| spellingShingle | Angela Lau Christopher Lin James Barrie Christopher Winter Gavin Armstrong Mary Lou Egedahl Alexander Doroshenko Courtney Heffernan Leyla Asadi Dina Fisher Catherine Paulsen Jalal Moolji Yiming Huang Richard Long A comparison of the chest radiographic and computed tomographic features of subclinical pulmonary tuberculosis Scientific Reports |
| title | A comparison of the chest radiographic and computed tomographic features of subclinical pulmonary tuberculosis |
| title_full | A comparison of the chest radiographic and computed tomographic features of subclinical pulmonary tuberculosis |
| title_fullStr | A comparison of the chest radiographic and computed tomographic features of subclinical pulmonary tuberculosis |
| title_full_unstemmed | A comparison of the chest radiographic and computed tomographic features of subclinical pulmonary tuberculosis |
| title_short | A comparison of the chest radiographic and computed tomographic features of subclinical pulmonary tuberculosis |
| title_sort | comparison of the chest radiographic and computed tomographic features of subclinical pulmonary tuberculosis |
| url | https://doi.org/10.1038/s41598-022-21016-7 |
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