CONSIDERATIONS REGARDING THE PATHOPHYSIOLOGICAL CHANGES IN THE PERIODONTITIS – DIABETES MELLITUS – COVID-19 TRIAD. REVIEW
Studies in the biology of viral infection and clinical disease management have shown that differences in the prevalence and severity of COVID-19 are associated with the high affinity of Covid-19 S protein for ACE2, suggesting that populations with higher ACE2 expression may be more susceptible to th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Romanian Dental Association for Education
2022-04-01
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| Series: | Romanian Journal of Medical and Dental Education |
| Subjects: | |
| Online Access: | https://journal.adre.ro/considerations-regarding-the-pathophysiological-changes-in-the-periodontitis-diabetes-mellitus-covid-19-triad-review/ |
| _version_ | 1797986663954120704 |
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| author | Diana-Maria Anton Irina-Georgeta Sufaru Maria-Alexandra Martu Raluca-Cristina Mocanu George-Alexandru Maftei Alexandru Flondor Liliana Pasarin Silvia Martu |
| author_facet | Diana-Maria Anton Irina-Georgeta Sufaru Maria-Alexandra Martu Raluca-Cristina Mocanu George-Alexandru Maftei Alexandru Flondor Liliana Pasarin Silvia Martu |
| author_sort | Diana-Maria Anton |
| collection | DOAJ |
| description | Studies in the biology of viral infection and clinical disease management have shown that differences in the prevalence and severity of COVID-19 are associated with the high affinity of Covid-19 S protein for ACE2, suggesting that populations with higher ACE2 expression may be more susceptible to the COVID-19 infection. Current information indicates that induced hyperglycaemia affects the phagocytic function of mononuclear and polymorphonuclear cells, contributing to the growth of aggressive pathogenic subgingival flora. As a result, periodontal infection can cause systemic inflammation by releasing cytokines and metalloproteinases (MMP) into the circulatory system derived from periodontal disease and destroying tissues, which can exacerbate or aggravate chronic insulin resistance. In the periodontitis – diabetes mellitus – COVID-19 triad, uncontrolled hyperglycaemia increases the risk of periodontitis and the onset of ACE2 overexpression, as well as decreased MMP activity in the periodontal tissue of patients with type 2 diabetes; these events could be essential for SARS-CoV-2 infection and COVID-19 development. |
| first_indexed | 2024-04-11T07:35:31Z |
| format | Article |
| id | doaj.art-b9bef552ec6d40f2aea9c5e732505e2b |
| institution | Directory Open Access Journal |
| issn | 2393-1108 2393-1531 |
| language | English |
| last_indexed | 2024-04-11T07:35:31Z |
| publishDate | 2022-04-01 |
| publisher | Romanian Dental Association for Education |
| record_format | Article |
| series | Romanian Journal of Medical and Dental Education |
| spelling | doaj.art-b9bef552ec6d40f2aea9c5e732505e2b2022-12-22T04:36:44ZengRomanian Dental Association for EducationRomanian Journal of Medical and Dental Education2393-11082393-15312022-04-011125662CONSIDERATIONS REGARDING THE PATHOPHYSIOLOGICAL CHANGES IN THE PERIODONTITIS – DIABETES MELLITUS – COVID-19 TRIAD. REVIEWDiana-Maria Anton0Irina-Georgeta Sufaru1Maria-Alexandra Martu2Raluca-Cristina Mocanu3George-Alexandru Maftei4Alexandru Flondor5Liliana Pasarin6Silvia Martu7Phd student ”Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, RomaniaGrigore T. Popa” University of Medicine and Pharmacy, Faculty of Dental Medicine, Department of Periodontology, Iaşi, Romania,Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Dental Medicine, Department of Periodontology, Iaşi, Romania,Phd student ”Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Dental Medicine, Department of Oral Pathology, Iaşi, RomaniaPhd student ”Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, RomaniaGrigore T. Popa” University of Medicine and Pharmacy, Faculty of Dental Medicine, Department of Periodontology, Iaşi, Romania,Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Dental Medicine, Department of Periodontology, Iaşi, Romania,Studies in the biology of viral infection and clinical disease management have shown that differences in the prevalence and severity of COVID-19 are associated with the high affinity of Covid-19 S protein for ACE2, suggesting that populations with higher ACE2 expression may be more susceptible to the COVID-19 infection. Current information indicates that induced hyperglycaemia affects the phagocytic function of mononuclear and polymorphonuclear cells, contributing to the growth of aggressive pathogenic subgingival flora. As a result, periodontal infection can cause systemic inflammation by releasing cytokines and metalloproteinases (MMP) into the circulatory system derived from periodontal disease and destroying tissues, which can exacerbate or aggravate chronic insulin resistance. In the periodontitis – diabetes mellitus – COVID-19 triad, uncontrolled hyperglycaemia increases the risk of periodontitis and the onset of ACE2 overexpression, as well as decreased MMP activity in the periodontal tissue of patients with type 2 diabetes; these events could be essential for SARS-CoV-2 infection and COVID-19 development.https://journal.adre.ro/considerations-regarding-the-pathophysiological-changes-in-the-periodontitis-diabetes-mellitus-covid-19-triad-review/gingivitisperiodontitiscytokinesdiabetes mellituscovid-19 |
| spellingShingle | Diana-Maria Anton Irina-Georgeta Sufaru Maria-Alexandra Martu Raluca-Cristina Mocanu George-Alexandru Maftei Alexandru Flondor Liliana Pasarin Silvia Martu CONSIDERATIONS REGARDING THE PATHOPHYSIOLOGICAL CHANGES IN THE PERIODONTITIS – DIABETES MELLITUS – COVID-19 TRIAD. REVIEW Romanian Journal of Medical and Dental Education gingivitis periodontitis cytokines diabetes mellitus covid-19 |
| title | CONSIDERATIONS REGARDING THE PATHOPHYSIOLOGICAL CHANGES IN THE PERIODONTITIS – DIABETES MELLITUS – COVID-19 TRIAD. REVIEW |
| title_full | CONSIDERATIONS REGARDING THE PATHOPHYSIOLOGICAL CHANGES IN THE PERIODONTITIS – DIABETES MELLITUS – COVID-19 TRIAD. REVIEW |
| title_fullStr | CONSIDERATIONS REGARDING THE PATHOPHYSIOLOGICAL CHANGES IN THE PERIODONTITIS – DIABETES MELLITUS – COVID-19 TRIAD. REVIEW |
| title_full_unstemmed | CONSIDERATIONS REGARDING THE PATHOPHYSIOLOGICAL CHANGES IN THE PERIODONTITIS – DIABETES MELLITUS – COVID-19 TRIAD. REVIEW |
| title_short | CONSIDERATIONS REGARDING THE PATHOPHYSIOLOGICAL CHANGES IN THE PERIODONTITIS – DIABETES MELLITUS – COVID-19 TRIAD. REVIEW |
| title_sort | considerations regarding the pathophysiological changes in the periodontitis diabetes mellitus covid 19 triad review |
| topic | gingivitis periodontitis cytokines diabetes mellitus covid-19 |
| url | https://journal.adre.ro/considerations-regarding-the-pathophysiological-changes-in-the-periodontitis-diabetes-mellitus-covid-19-triad-review/ |
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