Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice

Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice

Abstract The anti-apoptotic function of Bcl-xL in the heart during ischemia/reperfusion is diminished by K-Ras-Mst1-mediated phosphorylation of Ser14, which allows dissociation of Bcl-xL from Bax and promotes cardiomyocyte death. Here we show that Ser14 phosphorylation of Bcl-xL is also promoted by...

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Main Authors: Michinari Nakamura, Mariko Aoyagi Keller, Nadezhda Fefelova, Peiyong Zhai, Tong Liu, Yimin Tian, Shohei Ikeda, Dominic P. Del Re, Hong Li, Lai-Hua Xie, Junichi Sadoshima
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41595-x

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