Tailored pharmacist-led intervention to improve adherence to Iron supplementation in premature infants: a randomized controlled trial in China
IntroductionPrematurity is due to a number of factors, especially genetics. This study was designed to evaluate the impact of a pharmacist-led patient-centered medication therapy management trial on iron deficiency and medication adherence among premature infants receiving iron supplementation at a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1288347/full |
| _version_ | 1797663293091872768 |
|---|---|
| author | Beimeng Yu Beimeng Yu Ming Ni Ming Ni Haijing Li Renjie Xu Renjie Xu Aiping Wang |
| author_facet | Beimeng Yu Beimeng Yu Ming Ni Ming Ni Haijing Li Renjie Xu Renjie Xu Aiping Wang |
| author_sort | Beimeng Yu |
| collection | DOAJ |
| description | IntroductionPrematurity is due to a number of factors, especially genetics. This study was designed to evaluate the impact of a pharmacist-led patient-centered medication therapy management trial on iron deficiency and medication adherence among premature infants receiving iron supplementation at a tertiary hospital in Shaoxing, China.MethodsIn this randomised controlled trial, eighty-one premature infants, with or without genetic factors, born at 26 to 30 weeks and 6 days gestational age, will be recruited and randomised to an intervention group or a control group. The intervention group will receive a pharmacist-driven discharge counseling on iron supplements from recruitment, until 12 months. The control group will receive care as usual. The main outcomes were haemoglobin (g/L), serum iron (μg/L), medication adherence estimation and differentiation scale, the satisfaction with information about medicines scale, beliefs about medicines questionnaire and the Bayley scales for infant development.ResultsA total of 81 patients were enrolled in the study. After intervention, results for the haemoglobin and serum iron differed significantly between the control group and the intervention group (101.36 vs. 113.55, P < 0.0001 and 51.13 vs. 101.36, P = 0.004). Additionally, there was a substantial difference between the intervention group and the control group in terms of patient medication adherence estimation and differentiation scale (27 vs. 34, P = 0.0002). the intervention group had better mental development index and psychomotor development index, compared with the control group (91.03 vs. 87.29, P = 0.035 and 95.05 vs. 90.00, P = 0.022).DiscussionIn premature infants with iron deficiency, our pharmacist-led team significantly improved clinical outcomes and medication adherence. |
| first_indexed | 2024-03-11T19:12:24Z |
| format | Article |
| id | doaj.art-b9bfd06d4767470e8c0a6a5b9afa3260 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T19:12:24Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-b9bfd06d4767470e8c0a6a5b9afa32602023-10-09T10:50:39ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12883471288347Tailored pharmacist-led intervention to improve adherence to Iron supplementation in premature infants: a randomized controlled trial in ChinaBeimeng Yu0Beimeng Yu1Ming Ni2Ming Ni3Haijing Li4Renjie Xu5Renjie Xu6Aiping Wang7Shaoxing Key Laboratory of Reproductive Health, Shaoxing Maternity and Child Health Care Hospital, Shaoxing, Zhejiang, ChinaNeonatal Intensive Care Unit, Shaoxing Maternity and Child Health Care Hospital, Shaoxing, Zhejiang, ChinaShaoxing Key Laboratory of Reproductive Health, Shaoxing Maternity and Child Health Care Hospital, Shaoxing, Zhejiang, ChinaDepartment of Clinical Pharmacy, Shaoxing Maternity and Child Health Care Hospital, Shaoxing, Zhejiang, ChinaShaoxing Key Laboratory of Reproductive Health, Shaoxing Maternity and Child Health Care Hospital, Shaoxing, Zhejiang, ChinaShaoxing Key Laboratory of Reproductive Health, Shaoxing Maternity and Child Health Care Hospital, Shaoxing, Zhejiang, ChinaDepartment of Clinical Pharmacy, Shaoxing Maternity and Child Health Care Hospital, Shaoxing, Zhejiang, ChinaGynecological Fifth Ward, Shaoxing Maternity and Child Health Care Hospital, Shaoxing, Zhejiang, ChinaIntroductionPrematurity is due to a number of factors, especially genetics. This study was designed to evaluate the impact of a pharmacist-led patient-centered medication therapy management trial on iron deficiency and medication adherence among premature infants receiving iron supplementation at a tertiary hospital in Shaoxing, China.MethodsIn this randomised controlled trial, eighty-one premature infants, with or without genetic factors, born at 26 to 30 weeks and 6 days gestational age, will be recruited and randomised to an intervention group or a control group. The intervention group will receive a pharmacist-driven discharge counseling on iron supplements from recruitment, until 12 months. The control group will receive care as usual. The main outcomes were haemoglobin (g/L), serum iron (μg/L), medication adherence estimation and differentiation scale, the satisfaction with information about medicines scale, beliefs about medicines questionnaire and the Bayley scales for infant development.ResultsA total of 81 patients were enrolled in the study. After intervention, results for the haemoglobin and serum iron differed significantly between the control group and the intervention group (101.36 vs. 113.55, P < 0.0001 and 51.13 vs. 101.36, P = 0.004). Additionally, there was a substantial difference between the intervention group and the control group in terms of patient medication adherence estimation and differentiation scale (27 vs. 34, P = 0.0002). the intervention group had better mental development index and psychomotor development index, compared with the control group (91.03 vs. 87.29, P = 0.035 and 95.05 vs. 90.00, P = 0.022).DiscussionIn premature infants with iron deficiency, our pharmacist-led team significantly improved clinical outcomes and medication adherence.https://www.frontiersin.org/articles/10.3389/fendo.2023.1288347/fulliron supplementationgeneticsmedication adherencehaemoglobinpremature infants |
| spellingShingle | Beimeng Yu Beimeng Yu Ming Ni Ming Ni Haijing Li Renjie Xu Renjie Xu Aiping Wang Tailored pharmacist-led intervention to improve adherence to Iron supplementation in premature infants: a randomized controlled trial in China Frontiers in Endocrinology iron supplementation genetics medication adherence haemoglobin premature infants |
| title | Tailored pharmacist-led intervention to improve adherence to Iron supplementation in premature infants: a randomized controlled trial in China |
| title_full | Tailored pharmacist-led intervention to improve adherence to Iron supplementation in premature infants: a randomized controlled trial in China |
| title_fullStr | Tailored pharmacist-led intervention to improve adherence to Iron supplementation in premature infants: a randomized controlled trial in China |
| title_full_unstemmed | Tailored pharmacist-led intervention to improve adherence to Iron supplementation in premature infants: a randomized controlled trial in China |
| title_short | Tailored pharmacist-led intervention to improve adherence to Iron supplementation in premature infants: a randomized controlled trial in China |
| title_sort | tailored pharmacist led intervention to improve adherence to iron supplementation in premature infants a randomized controlled trial in china |
| topic | iron supplementation genetics medication adherence haemoglobin premature infants |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1288347/full |
| work_keys_str_mv | AT beimengyu tailoredpharmacistledinterventiontoimproveadherencetoironsupplementationinprematureinfantsarandomizedcontrolledtrialinchina AT beimengyu tailoredpharmacistledinterventiontoimproveadherencetoironsupplementationinprematureinfantsarandomizedcontrolledtrialinchina AT mingni tailoredpharmacistledinterventiontoimproveadherencetoironsupplementationinprematureinfantsarandomizedcontrolledtrialinchina AT mingni tailoredpharmacistledinterventiontoimproveadherencetoironsupplementationinprematureinfantsarandomizedcontrolledtrialinchina AT haijingli tailoredpharmacistledinterventiontoimproveadherencetoironsupplementationinprematureinfantsarandomizedcontrolledtrialinchina AT renjiexu tailoredpharmacistledinterventiontoimproveadherencetoironsupplementationinprematureinfantsarandomizedcontrolledtrialinchina AT renjiexu tailoredpharmacistledinterventiontoimproveadherencetoironsupplementationinprematureinfantsarandomizedcontrolledtrialinchina AT aipingwang tailoredpharmacistledinterventiontoimproveadherencetoironsupplementationinprematureinfantsarandomizedcontrolledtrialinchina |