Immunopathogenesis and neurological manifestations associated to HTLV-1 infection
The human T lymphotropic virus type-1 (HTLV-1) was the first human retrovirus identified. The virus is transmitted through sexual intercourse, blood transfusion, sharing of contaminated needles or syringes and from mother to child, mainly through breastfeeding. In addition to the well-known associat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2012-10-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000500002&lng=en&tlng=en |
| _version_ | 1817976863396462592 |
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| author | Anselmo Souza Davi Tanajura Cristina Toledo-Cornell Silvane Santos Edgar Marcelino de Carvalho |
| author_facet | Anselmo Souza Davi Tanajura Cristina Toledo-Cornell Silvane Santos Edgar Marcelino de Carvalho |
| author_sort | Anselmo Souza |
| collection | DOAJ |
| description | The human T lymphotropic virus type-1 (HTLV-1) was the first human retrovirus identified. The virus is transmitted through sexual intercourse, blood transfusion, sharing of contaminated needles or syringes and from mother to child, mainly through breastfeeding. In addition to the well-known association between HTLV-1 and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), several diseases and neurologic manifestations have been associated with the virus. This review was conducted through a PubMed search of the terms HTLV-1, immune response and neurological diseases. Emphasis was given to the most recent data regarding pathogenesis and clinical manifestations of HTLV-1 infection. The aim of the review is to analyze the immune response and the variety of neurological manifestations associated to HTLV-1 infection. A total of 102 articles were reviewed. The literature shows that a large percentage of HTLV-1 infected individuals have others neurological symptoms than HAM/TSP. Increased understanding of these numerous others clinical manifestations associated to the virus than adult T cell leukemia/lymphoma (ATLL) and HAM/TSP has challenged the view that HTLV-1 is a low morbidity infection. |
| first_indexed | 2024-04-13T22:09:18Z |
| format | Article |
| id | doaj.art-b9c0068059ba47ba80720edbf1532f7d |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T22:09:18Z |
| publishDate | 2012-10-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-b9c0068059ba47ba80720edbf1532f7d2022-12-22T02:27:50ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492012-10-0145554555210.1590/S0037-86822012000500002S0037-86822012000500002Immunopathogenesis and neurological manifestations associated to HTLV-1 infectionAnselmo Souza0Davi Tanajura1Cristina Toledo-Cornell2Silvane Santos3Edgar Marcelino de Carvalho4Universidade Federal da BahiaUniversidade Federal da BahiaUniversidade Federal da BahiaUniversidade Federal da BahiaUniversidade Federal da BahiaThe human T lymphotropic virus type-1 (HTLV-1) was the first human retrovirus identified. The virus is transmitted through sexual intercourse, blood transfusion, sharing of contaminated needles or syringes and from mother to child, mainly through breastfeeding. In addition to the well-known association between HTLV-1 and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), several diseases and neurologic manifestations have been associated with the virus. This review was conducted through a PubMed search of the terms HTLV-1, immune response and neurological diseases. Emphasis was given to the most recent data regarding pathogenesis and clinical manifestations of HTLV-1 infection. The aim of the review is to analyze the immune response and the variety of neurological manifestations associated to HTLV-1 infection. A total of 102 articles were reviewed. The literature shows that a large percentage of HTLV-1 infected individuals have others neurological symptoms than HAM/TSP. Increased understanding of these numerous others clinical manifestations associated to the virus than adult T cell leukemia/lymphoma (ATLL) and HAM/TSP has challenged the view that HTLV-1 is a low morbidity infection.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000500002&lng=en&tlng=enHTLV-1Resposta imuneHAM/TSPDoença neurológica |
| spellingShingle | Anselmo Souza Davi Tanajura Cristina Toledo-Cornell Silvane Santos Edgar Marcelino de Carvalho Immunopathogenesis and neurological manifestations associated to HTLV-1 infection Revista da Sociedade Brasileira de Medicina Tropical HTLV-1 Resposta imune HAM/TSP Doença neurológica |
| title | Immunopathogenesis and neurological manifestations associated to HTLV-1 infection |
| title_full | Immunopathogenesis and neurological manifestations associated to HTLV-1 infection |
| title_fullStr | Immunopathogenesis and neurological manifestations associated to HTLV-1 infection |
| title_full_unstemmed | Immunopathogenesis and neurological manifestations associated to HTLV-1 infection |
| title_short | Immunopathogenesis and neurological manifestations associated to HTLV-1 infection |
| title_sort | immunopathogenesis and neurological manifestations associated to htlv 1 infection |
| topic | HTLV-1 Resposta imune HAM/TSP Doença neurológica |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000500002&lng=en&tlng=en |
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