Target Screen of Anti-Hyperuricemia Compounds from Cortex Fraxini In Vivo Based on ABCG2 and Bioaffinity Ultrafiltration Mass Spectrometry

Target Screen of Anti-Hyperuricemia Compounds from Cortex Fraxini In Vivo Based on ABCG2 and Bioaffinity Ultrafiltration Mass Spectrometry

The ATP-binding cassette (ABC) transporter ABCG2 is a significant urate transporter with a high capacity, and it plays a crucial role in the development of hyperuricemia and gout. Therefore, it has the potential to be targeted for therapeutic interventions. Cortex Fraxini, a traditional Chinese medi...

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Bibliographic Details
Main Authors: Xiuxiu Huang, Wenqing Dong, Xiao Luo, Lu Xu, Yinan Wang
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
hyperuricemia
uric acid
ABCG2
ultrafiltration
Cortex Fraxini
fraxin
Online Access:https://www.mdpi.com/1420-3049/28/23/7896

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