Mast Cell-activated Bone Marrow Mesenchymal Stromal Cells Regulate Proliferation and Lineage Commitment of CD34+ Progenitor cells

Mast Cell-activated Bone Marrow Mesenchymal Stromal Cells Regulate Proliferation and Lineage Commitment of CD34+ Progenitor cells

Background: Shortly after allergen exposure, the number of bone marrow and circulating CD34+ progenitors increases. We aim to analyze the possible mechanism whereby the allergic reaction stimulates bone marrow to release these effector cells in increased numbers. We hypothesize that mast cells may p...

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Bibliographic Details
Main Authors: Zoulfia eAllakhverdi, Michael R Comeau, Myriam eArmant, Rachana eAgrawal, Judith A Woodfolk, Roma eSehmi, Karen J Howie, Gail M Gauvreau, Guy eDelespesse
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Immunology
Subjects:
Asthma
Mast Cells
allergic inflammation
bone marrow mesenchymal stromal cells
Th2 response
TSLP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00461/full

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