Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population
Abstract Background Staphylococcus aureus (SA) nasal carriage (SA carriage) and IgE-sensitization to SA enterotoxin (SE IgE-sensitization) are known to be associated with chronic airway disease. Objective This study aimed to evaluate the differences in risk factors, type 2 inflammation and respirato...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-01-01
|
| Series: | Allergy, Asthma & Clinical Immunology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13223-022-00648-4 |
| _version_ | 1798023870203035648 |
|---|---|
| author | Han-Ki Park Seok-Ju Yoo Taek Soo Kim Byung-Keun Kim Sekyung Jang Sung Yeon Kim Kwan Lee |
| author_facet | Han-Ki Park Seok-Ju Yoo Taek Soo Kim Byung-Keun Kim Sekyung Jang Sung Yeon Kim Kwan Lee |
| author_sort | Han-Ki Park |
| collection | DOAJ |
| description | Abstract Background Staphylococcus aureus (SA) nasal carriage (SA carriage) and IgE-sensitization to SA enterotoxin (SE IgE-sensitization) are known to be associated with chronic airway disease. Objective This study aimed to evaluate the differences in risk factors, type 2 inflammation and respiratory symptoms between SA carriage and SE IgE-sensitization. Methods We conducted a cross-sectional study of a community-based adult population to evaluate the environmental exposure and health impact of the Pohang Industrial Complex, Korea. Participants were examined based on self-reported questionnaires, nasal swab, and blood sampling. Results There were 307 participants, and the overall prevalence of SA carriage and SE IgE-sensitization was 26.1% (80/307) and 25.7% (79/307), respectively. An urban environment was significantly correlated with SA carriage, whereas age and obesity were significantly correlated with SE IgE-sensitization. SA carriage was not associated with an increase in total IgE and blood eosinophil count, whereas SE IgE-sensitization was associated with an increased total IgE and blood eosinophil count. SA carriage was significantly correlated with cough persisting for more than three weeks (OR, 3.044; 95% CI, 1.137–8.153) and sputum (OR, 2.429; 95% CI, 1.008–5.854). SE IgE-sensitization was a significant correlation with only sputum (OR, 2.452; 95% CI, 1.066–5.640). SA carriage and SE IgE-sensitization showed a synergistic effect on the prevalence of cough and sputum. Conclusion SA carriage was associated with the urban environment, and SE IgE-sensitization was associated with the elderly and obesity. SA carriage and SE IgE-sensitization had different correlation with type 2 inflammation and airway symptoms. |
| first_indexed | 2024-04-11T17:53:32Z |
| format | Article |
| id | doaj.art-b9c1a49aaca0482caa7094ecffa2192f |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-04-11T17:53:32Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-b9c1a49aaca0482caa7094ecffa2192f2022-12-22T04:10:59ZengBMCAllergy, Asthma & Clinical Immunology1710-14922022-01-0118111010.1186/s13223-022-00648-4Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult populationHan-Ki Park0Seok-Ju Yoo1Taek Soo Kim2Byung-Keun Kim3Sekyung Jang4Sung Yeon Kim5Kwan Lee6Department of Allergy and Clinical Immunology, School of Medicine, Kyungpook National UniversityDepartment of Preventive Medicine, College of Medicine, Dongguk UniversityDepartment of Laboratory Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Korea University College of MedicineEnvironmental Health Research Division, National Institute of Environmental ResearchEnvironmental Health Research Division, National Institute of Environmental ResearchDepartment of Preventive Medicine, College of Medicine, Dongguk UniversityAbstract Background Staphylococcus aureus (SA) nasal carriage (SA carriage) and IgE-sensitization to SA enterotoxin (SE IgE-sensitization) are known to be associated with chronic airway disease. Objective This study aimed to evaluate the differences in risk factors, type 2 inflammation and respiratory symptoms between SA carriage and SE IgE-sensitization. Methods We conducted a cross-sectional study of a community-based adult population to evaluate the environmental exposure and health impact of the Pohang Industrial Complex, Korea. Participants were examined based on self-reported questionnaires, nasal swab, and blood sampling. Results There were 307 participants, and the overall prevalence of SA carriage and SE IgE-sensitization was 26.1% (80/307) and 25.7% (79/307), respectively. An urban environment was significantly correlated with SA carriage, whereas age and obesity were significantly correlated with SE IgE-sensitization. SA carriage was not associated with an increase in total IgE and blood eosinophil count, whereas SE IgE-sensitization was associated with an increased total IgE and blood eosinophil count. SA carriage was significantly correlated with cough persisting for more than three weeks (OR, 3.044; 95% CI, 1.137–8.153) and sputum (OR, 2.429; 95% CI, 1.008–5.854). SE IgE-sensitization was a significant correlation with only sputum (OR, 2.452; 95% CI, 1.066–5.640). SA carriage and SE IgE-sensitization showed a synergistic effect on the prevalence of cough and sputum. Conclusion SA carriage was associated with the urban environment, and SE IgE-sensitization was associated with the elderly and obesity. SA carriage and SE IgE-sensitization had different correlation with type 2 inflammation and airway symptoms.https://doi.org/10.1186/s13223-022-00648-4Staphylococcus aureusStaphylococcal enterotoxinsRisk factorsImmunoglobulin EEosinophilCough |
| spellingShingle | Han-Ki Park Seok-Ju Yoo Taek Soo Kim Byung-Keun Kim Sekyung Jang Sung Yeon Kim Kwan Lee Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population Allergy, Asthma & Clinical Immunology Staphylococcus aureus Staphylococcal enterotoxins Risk factors Immunoglobulin E Eosinophil Cough |
| title | Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population |
| title_full | Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population |
| title_fullStr | Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population |
| title_full_unstemmed | Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population |
| title_short | Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population |
| title_sort | differences between staphylococcus aureus nasal carriage and ige sensitization to staphylococcus aureus enterotoxin on risk factors and effects in adult population |
| topic | Staphylococcus aureus Staphylococcal enterotoxins Risk factors Immunoglobulin E Eosinophil Cough |
| url | https://doi.org/10.1186/s13223-022-00648-4 |
| work_keys_str_mv | AT hankipark differencesbetweenstaphylococcusaureusnasalcarriageandigesensitizationtostaphylococcusaureusenterotoxinonriskfactorsandeffectsinadultpopulation AT seokjuyoo differencesbetweenstaphylococcusaureusnasalcarriageandigesensitizationtostaphylococcusaureusenterotoxinonriskfactorsandeffectsinadultpopulation AT taeksookim differencesbetweenstaphylococcusaureusnasalcarriageandigesensitizationtostaphylococcusaureusenterotoxinonriskfactorsandeffectsinadultpopulation AT byungkeunkim differencesbetweenstaphylococcusaureusnasalcarriageandigesensitizationtostaphylococcusaureusenterotoxinonriskfactorsandeffectsinadultpopulation AT sekyungjang differencesbetweenstaphylococcusaureusnasalcarriageandigesensitizationtostaphylococcusaureusenterotoxinonriskfactorsandeffectsinadultpopulation AT sungyeonkim differencesbetweenstaphylococcusaureusnasalcarriageandigesensitizationtostaphylococcusaureusenterotoxinonriskfactorsandeffectsinadultpopulation AT kwanlee differencesbetweenstaphylococcusaureusnasalcarriageandigesensitizationtostaphylococcusaureusenterotoxinonriskfactorsandeffectsinadultpopulation |