The identification of small molecule inhibitors with anthelmintic activities that target conserved proteins among ruminant gastrointestinal nematodes

The identification of small molecule inhibitors with anthelmintic activities that target conserved proteins among ruminant gastrointestinal nematodes

ABSTRACT Gastrointestinal nematode (GIN) infections are a major concern for the ruminant industry worldwide and result in significant production losses. Naturally occurring polyparasitism and increasing drug resistance that potentiate disease outcomes are observed among the most prevalent GINs of ve...

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Bibliographic Details
Main Authors: Hyeim Jung, Dante Zarlenga, John C. Martin, Peter Geldhof, Kymberlie Hallsworth-Pepin, Makedonka Mitreva
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mBio
Subjects:
Trichostrongylus colubriformis
Ostertagia ostertagi
Cooperia oncophora
genomes
ruminants
drug targets
Online Access:https://journals.asm.org/doi/10.1128/mbio.00095-24

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