Case report: Two unique cases of co-existing primary brain tumors of glial origin in opposite hemispheres
BackgroundPrimary CNS tumors are rare. Coexistence of two glial tumors of different histological origins in the same patient is even rarer. Here we describe two unique cases of coexisting distinct glial tumors in opposite hemispheres.CasesPatient 1 is a 38-year-old male who presented with a seizure...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1018840/full |
| _version_ | 1811190000019046400 |
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| author | Ishan Singhal Dylan Coss Wade Mueller Michael Straza Max Ostrinsky Krucoff Max Ostrinsky Krucoff Fernando Santos-Pinheiro |
| author_facet | Ishan Singhal Dylan Coss Wade Mueller Michael Straza Max Ostrinsky Krucoff Max Ostrinsky Krucoff Fernando Santos-Pinheiro |
| author_sort | Ishan Singhal |
| collection | DOAJ |
| description | BackgroundPrimary CNS tumors are rare. Coexistence of two glial tumors of different histological origins in the same patient is even rarer. Here we describe two unique cases of coexisting distinct glial tumors in opposite hemispheres.CasesPatient 1 is a 38-year-old male who presented with a seizure in February/2016. MRI showed a left parietal and a right frontal infiltrating nonenhancing lesions. Both lesions were resected revealing an oligodendroglioma WHO grade-2 and an astrocytoma WHO grade-2. Patient 2 is a 34-year-old male who presented with a seizure in November/2021. MRI showed a left frontal and a right mesial temporal lobe infiltrating nonenhancing lesions. Both lesions were resected revealing an oligodendroglioma WHO grade-2 and a diffuse low-grade glioma, MAPK pathway-altered (BRAF V600E-mutant). Patient 1 underwent adjuvant treatment. Both patients are without recurrence to date.DiscussionTwo histologically distinct glial tumors may coexist, especially when they are non-contiguous. Pathological confirmation of each lesion is imperative for appropriate management. We highlight the different management of gliomas based on the new CNS WHO 2021 classification compared to its 2016 version, based on NCCN guidelines. Although more molecular markers are being incorporated into glioma classification, their clinical impact of it is yet to be determined. |
| first_indexed | 2024-04-11T14:43:37Z |
| format | Article |
| id | doaj.art-b9c2fa2ed5a74e2aa2bc8e92d840e851 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T14:43:37Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b9c2fa2ed5a74e2aa2bc8e92d840e8512022-12-22T04:17:45ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10188401018840Case report: Two unique cases of co-existing primary brain tumors of glial origin in opposite hemispheresIshan Singhal0Dylan Coss1Wade Mueller2Michael Straza3Max Ostrinsky Krucoff4Max Ostrinsky Krucoff5Fernando Santos-Pinheiro6Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Pathology, Medical College of Wisconsin & Froedtert Hospital, Milwaukee, WI, United StatesDepartment of Neurosurgery, Medical College of Wisconsin & Froedtert Hospital, Milwaukee, WI, United StatesDepartment of Radiation Oncology, Medical College of Wisconsin & Froedtert Hospital, Milwaukee, WI, United StatesDepartment of Neurosurgery, Medical College of Wisconsin & Froedtert Hospital, Milwaukee, WI, United StatesDepartment of Biomedical Engineering, Marquette University & Medical College of Wisconsin Graduate School, Milwaukee, WI, United StatesDepartment of Neurology, Medical College of Wisconsin & Froedtert Hospital, Milwaukee, WI, United StatesBackgroundPrimary CNS tumors are rare. Coexistence of two glial tumors of different histological origins in the same patient is even rarer. Here we describe two unique cases of coexisting distinct glial tumors in opposite hemispheres.CasesPatient 1 is a 38-year-old male who presented with a seizure in February/2016. MRI showed a left parietal and a right frontal infiltrating nonenhancing lesions. Both lesions were resected revealing an oligodendroglioma WHO grade-2 and an astrocytoma WHO grade-2. Patient 2 is a 34-year-old male who presented with a seizure in November/2021. MRI showed a left frontal and a right mesial temporal lobe infiltrating nonenhancing lesions. Both lesions were resected revealing an oligodendroglioma WHO grade-2 and a diffuse low-grade glioma, MAPK pathway-altered (BRAF V600E-mutant). Patient 1 underwent adjuvant treatment. Both patients are without recurrence to date.DiscussionTwo histologically distinct glial tumors may coexist, especially when they are non-contiguous. Pathological confirmation of each lesion is imperative for appropriate management. We highlight the different management of gliomas based on the new CNS WHO 2021 classification compared to its 2016 version, based on NCCN guidelines. Although more molecular markers are being incorporated into glioma classification, their clinical impact of it is yet to be determined.https://www.frontiersin.org/articles/10.3389/fonc.2022.1018840/fullneuro-oncologyoligodendrogliomagliomaastrocytomaco-existing tumors |
| spellingShingle | Ishan Singhal Dylan Coss Wade Mueller Michael Straza Max Ostrinsky Krucoff Max Ostrinsky Krucoff Fernando Santos-Pinheiro Case report: Two unique cases of co-existing primary brain tumors of glial origin in opposite hemispheres Frontiers in Oncology neuro-oncology oligodendroglioma glioma astrocytoma co-existing tumors |
| title | Case report: Two unique cases of co-existing primary brain tumors of glial origin in opposite hemispheres |
| title_full | Case report: Two unique cases of co-existing primary brain tumors of glial origin in opposite hemispheres |
| title_fullStr | Case report: Two unique cases of co-existing primary brain tumors of glial origin in opposite hemispheres |
| title_full_unstemmed | Case report: Two unique cases of co-existing primary brain tumors of glial origin in opposite hemispheres |
| title_short | Case report: Two unique cases of co-existing primary brain tumors of glial origin in opposite hemispheres |
| title_sort | case report two unique cases of co existing primary brain tumors of glial origin in opposite hemispheres |
| topic | neuro-oncology oligodendroglioma glioma astrocytoma co-existing tumors |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1018840/full |
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