The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis
Interactions between macrophages and adipocytes in adipose tissue are critical for the regulation of energy metabolism and obesity. Macrophage polarization induced by cold or other stimulations can drive metabolic reprogramming of adipocytes, browning, and thermogenesis. Accordingly, investigating t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1378202/full |
| _version_ | 1827291156429406208 |
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| author | Yudie Zhang Yudie Zhang Yudie Zhang Yudie Zhang Yudie Zhang Bin Zhang Bin Zhang Bin Zhang Bin Zhang Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun |
| author_facet | Yudie Zhang Yudie Zhang Yudie Zhang Yudie Zhang Yudie Zhang Bin Zhang Bin Zhang Bin Zhang Bin Zhang Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun |
| author_sort | Yudie Zhang |
| collection | DOAJ |
| description | Interactions between macrophages and adipocytes in adipose tissue are critical for the regulation of energy metabolism and obesity. Macrophage polarization induced by cold or other stimulations can drive metabolic reprogramming of adipocytes, browning, and thermogenesis. Accordingly, investigating the roles of macrophages and adipocytes in the maintenance of energy homeostasis is critical for the development of novel therapeutic approaches specifically targeting macrophages in metabolic disorders such as obesity. Current review outlines macrophage polarization not only regulates the release of central nervous system and inflammatory factors, but controls mitochondrial function, and other factor that induce metabolic reprogramming of adipocytes and maintain energy homeostasis. We also emphasized on how the adipocytes conversely motivate the polarization of macrophage. Exploring the interactions between adipocytes and macrophages may provide new therapeutic strategies for the management of obesity-related metabolic diseases. |
| first_indexed | 2024-04-24T12:31:01Z |
| format | Article |
| id | doaj.art-b9c4372a2f95443e9775696380b99a47 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T12:31:01Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b9c4372a2f95443e9775696380b99a472024-04-08T04:43:48ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-04-011510.3389/fimmu.2024.13782021378202The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasisYudie Zhang0Yudie Zhang1Yudie Zhang2Yudie Zhang3Yudie Zhang4Bin Zhang5Bin Zhang6Bin Zhang7Bin Zhang8Xiaobo Sun9Xiaobo Sun10Xiaobo Sun11Xiaobo Sun12Xiaobo Sun13Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaGuizhou University of Traditional Chinese Medicine, Guiyang, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Efficacy Evaluation of Chinese Medicine Against Glyeolipid Metabolism Disorder Disease, State Administration of Traditional Chinese Medicine, Beijing, ChinaInstitute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Efficacy Evaluation of Chinese Medicine Against Glyeolipid Metabolism Disorder Disease, State Administration of Traditional Chinese Medicine, Beijing, ChinaInstitute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaGuizhou University of Traditional Chinese Medicine, Guiyang, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Efficacy Evaluation of Chinese Medicine Against Glyeolipid Metabolism Disorder Disease, State Administration of Traditional Chinese Medicine, Beijing, ChinaInteractions between macrophages and adipocytes in adipose tissue are critical for the regulation of energy metabolism and obesity. Macrophage polarization induced by cold or other stimulations can drive metabolic reprogramming of adipocytes, browning, and thermogenesis. Accordingly, investigating the roles of macrophages and adipocytes in the maintenance of energy homeostasis is critical for the development of novel therapeutic approaches specifically targeting macrophages in metabolic disorders such as obesity. Current review outlines macrophage polarization not only regulates the release of central nervous system and inflammatory factors, but controls mitochondrial function, and other factor that induce metabolic reprogramming of adipocytes and maintain energy homeostasis. We also emphasized on how the adipocytes conversely motivate the polarization of macrophage. Exploring the interactions between adipocytes and macrophages may provide new therapeutic strategies for the management of obesity-related metabolic diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1378202/fullmacrophage polarizationmitochondrial functioninflammationenergy metabolismobesitybrown adipose tissue |
| spellingShingle | Yudie Zhang Yudie Zhang Yudie Zhang Yudie Zhang Yudie Zhang Bin Zhang Bin Zhang Bin Zhang Bin Zhang Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis Frontiers in Immunology macrophage polarization mitochondrial function inflammation energy metabolism obesity brown adipose tissue |
| title | The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis |
| title_full | The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis |
| title_fullStr | The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis |
| title_full_unstemmed | The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis |
| title_short | The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis |
| title_sort | molecular mechanism of macrophage adipocyte crosstalk in maintaining energy homeostasis |
| topic | macrophage polarization mitochondrial function inflammation energy metabolism obesity brown adipose tissue |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1378202/full |
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